Ankylosing Spondylitis (AS) is a debilitating, immune-mediated disease which causes inflammation of the joints between the vertebrae, leading to stiffness, pain, and eventually fusion of the spine. The underpinnings of AS are highly complex and span genetic, environmental, and immunologic factors. Insights from proteomic analysis helps with mapping risk factors and identifying potential therapeutic targets. Â
In this GEN webinar, our expert speaker, Nicholas Harvey, PhD, will present findings from the largest genome-wide association study (GWAS) meta-analysis of AS to date, integrating data across diverse ancestries (e.g. European, East Asian, Turkish, and Iranian) and multiple omic layers, including the transcriptome, proteome, Mendelian randomization, and microbiome. During the webinar, you will gain new insights into AS pathogenesis, therapeutic challenges, and novel avenues for precision medicine.
Key takeaways:
- The identification of novel AS loci and signals, including 27 new genome-wide significant loci and 86 independent non-MHC associations
- The connection between AS risk and secretor status in the gut microbiome
- The impact of longer leukocyte telomeres on AS susceptibility
- The role of cytokine biology in therapy efficacy
- How to prioritize genes by applying fine-mapping to highlight causal variants
A live Q&A session will follow the presentation, offering you a chance to pose questions to our expert panelists.
Produced with support from:
