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You can always be judged by your scars. This is the idea that sums up what researchers at Spanish National Cancer Research Centre (CNIO) claim is one of the new breakthroughs in basic and biomedical research, in their release of the “human REPAIRome.” The CNIO team, led by Felipe Cortés-Ledesma, PhD, head of the CNIO’s DNA Topology and DNA Breaks group, has identified and catalogued 20,000 types of scars that remain in repaired human DNA after a double-stranded break (DSB). They’ve called the resource the human REPAIRome—and have made the data available to the global scientific community through the human…

Psilocybin reversed chronic pain and psychiatric symptoms in mice.Image credit:©istock.com, microgenPeople who live with chronic pain also often experience psychiatric disorders, like depression or anxiety, complicating the treatment of both conditions. Although many of the same brain regions are suspected to be affected in pain and mood disorders, researchers have not been able to treat these simultaneously so far.1-3In a study published in Nature Neuroscience, researchers from the University of Pennsylvania showed that a single dose of psilocybin, a compound with psychoactive properties, improved symptoms of both chronic pain and depressive and anxiety-like behaviors in mice.4 The researchers explored two…

Magnesium is a key nutrient that benefits many parts of the body, from blood pressure to heart health to improving your sleep. The amount of magnesium that your body needs can vary, but these healthy snack recipes will give you a boost with 75 milligrams or more of magnesium per serving—that’s about 20% of the recommended daily amount for adults. Try our sweet and satisfying Strawberry-Almond Butter Energy Cups or our versatile and savory Sesame-Honey Roasted Cashews for a magnesium-rich bite that is as delicious as it is nutritious. Love any of these recipes? Join MyRecipes to save, search and…

Luke TaylorRio de JaneiroUS health agencies are preparing to furlough up to three quarters of their staff and health insurance premiums could rise for millions of Americans as lawmakers failed to reach an agreement on the national budget.Republican and Democratic representatives were unable to come to an agreement on federal health insurance subsidies or to draw up a temporary funding plan by the midnight deadline on 1 October, triggering a federal government shutdown. This means all non-essential government services will be stopped and 750 000 federal employees could be furloughed, the Congressional Budget Office estimates.1According to the fiscal 2026 contingency plan…

Credit: Meletios Verras/iStock/Getty Images Plus A new approach to CAR T cell therapy, involving engineering the cells to produce fusion proteins combining a cytokine and an antibody, has shown improved efficacy and safety in animal models of prostate and ovarian cancer. Published in Nature Biomedical Engineering, results of the study show early promise to enhance the performance of this therapeutic modality in solid tumors, which make up about 90% of cancer diagnoses.  “We believe this new strategy will provide a productive boost to current CAR T cell therapies and can be applicable to multiple cancer types,” said John P. Murad,…

Princess Diana’s favorite salmon recipe features a macadamia, lime and cilantro crust.Chef Darren McGrady shared the full step-by-step recipe in a recent YouTube video.The dish is served with spicy mayo and sauteed onions and peppers. Salmon is a delicious source of protein, omega-3 fatty acids and vitamins like B12 and D, but like any protein food, it can be easy to feel like you’ve run out of interesting ways to cook it. Luckily, Princess Diana’s former chef, Darren McGrady, is taking to social media to share the royal’s favorite way to nosh on a salmon fillet—and it may be just…

Some research-assessment frameworks rank individual departments or staff members.Credit: GettySteve Goodman had just completed a three-page referee’s letter for an academic colleague who was going for promotion in a law department, when he received a bundle of papers that surprised him. The package contained the recommendation letters of other referees. “They were eight to ten pages long,” he says, adding that he had never seen letters like these before.Goodman, an epidemiologist at Stanford University in California, describes what he read as having been written by people who had digested the colleague’s books, engaged with their arguments and produced a commentary…

How Do We Burn Carbs?In order to lose weight, you must burn more calories than you consume. This leads to long-term weight reduction, as your body ultimately taps into fat stores when it needs to burn calories for energy.Typically, we burn 200 to 400 calories per hour of walking, depending on your body size and the intensity of your workout, notes Harvard Health Publishing.Here’s how it works: The carbohydrates you eat are broken down into sugars and transported in your blood, according to Mayo Clinic. This causes a rise in blood sugar levels, which triggers your pancreas to release insulin to…

After looking for words that rhymed with lime, Sublime was the immediate and obvious winner.Credit: Mikhail GlabetsThe meaning behind our monikerSublime Systems, based in Somerville, Massachusetts, has developed a way to manufacture ‘clean’ cement using an electrochemical process which improves efficiency, durability and aesthetics, and avoids the carbon release caused by conventional production. The firm was set up in 2020 and now has more than 100 employees. In the penultimate article of a six-part series about science company names and how to choose them, co-founder and chief executive Leah Ellis reveals how she came up with Sublime Systems.For about 18…

Chronic kidney disease (CDK) is pervasive within the global population, affecting over 700 million people. The condition is widespread in both number of individuals affected and in causes. Existing medical conditions, environmental factors, and genetics all play a role in the development of CDK in an individual. One of the known genetic risk factors include a mutation in the apolipoprotein L1 (APOL1) gene, with two known risk variants dubbed G1 and G2. While these variants are rare in most populations, they have a higher prevalence in people with West African ancestry with up to 13% of the population having two…