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Analysis of 12 magic mushroom edibles reveals they do not contain psilocybin, the psychedelic compound produced by these mushrooms. Instead, many products contained undisclosed active ingredients. The researchers studied gummies and chocolates sold in Oregon, US. Some of these products contained syndelics — synthetic psychedelics. The researchers caution that the toxicology and pharmacology of these compounds are unknown. Undisclosed ingredients also included caffeine and botanical extracts from hemp and kava. “Syndelics represent a rapidly growing area of drug design, where medicinal chemists create novel compounds inspired by known psychedelic agents like psilocybin and LSD,” says Richard van Breemen, professor of pharmaceutical…

This 30-day plan is set at 1,800 calories, with modifications for 1,500 and 2,000 calories.Each day provides at least 74 grams of protein and 40 grams of fiber to support satiety, though most days come in higher than that.This plan follows the principles of the nutrient-rich Mediterranean diet while skipping added sugars. Reap the benefits of the nourishing Mediterranean diet while skipping added sugar in this delicious and flavor-packed 30-day plan. To make this plan work for most people, you’ll find three different calorie levels to choose from, plus meal-prep tips at the beginning of each week to make for…

Gut bacteria, microbiome. Bacteria inside the large intestine, concept, representation. 3D illustration. Gut bacteria, microbiome. Bacteria inside the large intestine, concept, representation. 3D illustration. [ChrisChrisW / Getty Images] Researchers at the University of Sydney in Australia have discovered that certain genes influence the health of the gut microbiome to protect against obesity and diabetes by coding for specific proteins called alpha-defensins. These findings open up new avenues for personalized treatments, because they show that the gut microbiome is shaped by more than just diet.  Researchers worldwide have been studying the human microbiome and its link to health and diseases for…

To make a safe and effective drug, pharmaceutical scientists must also analyze and manage impurities and stability. “This is a fundamental set of problems that has existed for as long as drug development itself,” says Jeff Patrick, PhD, who is the global functional lead of CMC analytical development at BioAgilytix Labs in Durham, NC. It’s also a set of problems that never goes away. So, scientists keep coming up with new methods to test and address impurity and stability. “Impurities are entities that should not be present in the drug and may have come from the process, equipment, or contaminants…

Ina Garten shares tips for preparing the crispest, juiciest and most flavorful chicken.Many tips focus on timing—when to add certain ingredients to enhance overall flavor.Discover some of Ina’s fan-favorite chicken recipes, along with a favorite from EatingWell. After 45 years in the food business as a television cook and cookbook author, Ina Garten has picked up several tricks for making delicious meals—especially chicken. Her chicken recipes are legendary. We love dishes like her Skillet-Roasted Chicken and Potatoes, a fan favorite, and the Chicken Pot Pie that keeps us cozy, or her Crispy Chicken with Lemon Orzo from her cookbook “Modern Comfort Food,” which compelled even actress…

A new scientific analysis suggests even a small amount of alcohol is unsafe when it comes to cancer risk. The researchers found that the negative health impacts of alcohol start with any level of use, and increase as consumption goes up.This analysis, called the Alcohol Intake & Health Study, was funded by the U.S. government to inform an update of the Dietary Guidelines for Americans for 2025–2030. A draft report was released in January and posted online for public comment.[1]But federal health officials do not intend to submit the final report to Congress as planned, says Tim Naimi, MD, MPH,…

Two types of Goodles macaroni and cheese are being recalled nationwide.This is due to undeclared milk and cashew allergens, with eight allergic reactions reported.The products were sold at Sprouts, Target, Walmart, Whole Foods and more. There’s an active recall on boxed macaroni and cheese products sold at Sprouts Farmers Market, Target, Walmart, Whole Foods Market and more grocery stores nationwide. The U.S. Food and Drug Administration (FDA) shares that this is due to undeclared allergens in the affected products. The macaroni and cheese impacted by this recall are two Goodles products: the plant-based white Cheddar variety with spirals and the…

3D rendering of cancer-associated fibroblasts CAF layer on tumor microenvironment.[Marcin Klapczynski/Getty Images] New research from the University of Pittsburgh shows that the low-oxygen and high acid levels of the tumor microenvironment (TME) put stress on mitochondria, creating events in these cellular energy producers that lead to T cell exhaustion. Their study, published in Immunity, shows that the toxicity of the TME results in mitochondria producing reactive oxygen species (ROS) that travel to a cell’s nucleus where it damages telomeres to produce a dysfunctional state in T cells. “The really exciting part about this research is that by preventing damage to…

Sponsored content brought to you by The compromise between sequencing speed and capacity has impacted research for years. To combat this conundrum, in 2018, MGI launched the high-throughput sequencer, DNBSEQ-T7 that can output 7Tb of high-quality data within 24 hours. Since its launch, over 400 T7 units have been placed internationally. The T7 supports diverse applications along with large-scale genomics projects, including a Brazilian national genomic sequencing project, the National Genome Project in Indonesia and the Genomics Thailand Initiative. Now, the next-generation powerhouse sequencer, T7+, will continue the transformative change in large-scale genomics. “We took everything scientists loved about the…

The Mediterranean diet may boost cognition & reduce your risk of developing dementia and depression.The diet is full of plant polyphenols and omega-3 fatty acids that help reduce inflammation.Choose healthy cooking methods, such as grilling or roasting, and eat fruit for dessert. The foods you eat play an essential role in staying sharp as you age, and nutrient-packed, flavor-rich and easy-to-follow eating patterns like the Mediterranean diet make the job easier. A smattering of studies reveals just how this eating plan can be a boon to your brain health and mood today—and in the future. Oh, and there are happiness…