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Maybe it’s piled-up housework, looming work deadlines, or negative news stories. Whatever the cause, feeling overwhelmed can seriously affect your mental state — and your physical health, too.“Overwhelm isn’t just ‘in your head.’ It activates deep stress circuits in the brain, which can result in flooding the body with [stress hormones like] cortisol and adrenaline,” says Hayley Nelson, PhD, a neuroscientist and the founder of The Academy of Cognitive and Behavioral Neuroscience, an online education platform, in Downingtown, Pennsylvania.In the short term, this sharpens your focus and primes you for action. But when stress lingers, it can impair memory and learning,…

Total Wine’s lead buyer picks four red wines under $25 perfect for Thanksgiving or any holiday dinner.Favorites include boxed Ropiteau Pinot Noir and berry-rich D’Autrefois Pinot Noir for crowd-pleasing pours.Edouard Delaunay Bourgogne and Cortese Nostru Frappato impress with earthy and strawberry-forward flavors. If you’re looking to impress your guests this holiday season, choosing from this curated list of red wines will do the trick. Total Wine & More’s lead buyer Brian Gelb is the company’s senior vice president of wine (my dream job title), and he hand-picked these four wines to be the gorgeous centerpiece of your holiday dinner spread.…

Credit: Jackie Niam / iStock / Getty Images Plus Ginkgo Bioworks has announced the launch of the Virtual Cell Pharmacology Initiative (VCPI) through Ginkgo Datapoints. This open-source platform is designed to build a standardized framework for virtual cell modeling in drug discovery by bringing together researchers, pharmaceutical companies and AI developers in a community-driven effort to create the largest public dataset of its kind, aiming to test at least 100,000 compounds and generate over 12 billion data points.  While virtual cell models have emerged as a potentially valuable tool for drug discovery, the lack of standardization, reliable wet lab methods and appropriate pharmacology data prevents these…

From Alzheimer’s-inspired beginnings to advanced organoid models, this postdoc explores the mysteries of the developing brain.Image credit:Cedars-Sinai, ©iStock, BannosukeQ | Write a brief introduction to yourself including the lab you work in and your research background. I am Madhura Subba Rao, a postdoctoral researcher in the Breunig Lab at Cedars-Sinai Medical Center, where I study neurodevelopment and pediatric brain tumors using human induced pluripotent stem cell (hiPSC)-derived organoids and multiomics approaches. With over a decade of experience in molecular neuroscience and disease modeling, I integrate in vivo and stem cell systems to explore mechanisms of brain development and disease.Q |…

Data from the TARGET-D randomized clinical trial showed that 85% of participants started the study with vitamin D levels below 40 ng/mL and used personalized doses of the sunshine vitamin to achieve the optimal range of 40-80 ng/mL.Just over 50% of the study’s 630 participants needed to take more than 5,000 IU per day of vitamin D to reach the optimal blood level range. The current daily recommended amount of vitamin D for adults is 600 IU. “Previous clinical trial research on vitamin D tested the potential impact of the same vitamin D dose for all participants without checking their…

This flavorful fall dinner is made in one skillet for quick cleanup.This dish is protein- and fiber-rich for a filling, satisfying meal.You can substitute the chicken cutlets with boneless, skinless chicken breasts or boneless, skinless chicken thighs. This Skillet Chicken with Apples & Dijon Cream Sauce is as comforting as it is delicious. Succulent protein-packed chicken is simply seasoned and pairs perfectly with sweet Honeycrisp apples and caramelized onions. The creamy, slightly tangy Dijon sauce clings to it all and is finished with a sprinkling of fresh thyme, bringing these classic fall flavors together. Keep reading for our expert tips,…

Doctors have accused ministers of “weaponising antisemitism” to silence healthcare professionals from speaking out against the genocide in Gaza.12In a letter sent to the Department of Health and Social Care (DHSC), Doctors in Unite—physician members of the trade union Unite—said government plans to tackle racism and antisemitism in the NHS are “racist and dangerous” and should be abandoned.The letter is backed by 23 organisations, including Jewish Voice for Liberation and Health Workers and Allies for Palestine.It was launched in response to a government plan to “end the scourge of antisemitism” in the NHS, which was announced last month.3As part of…

Credit: 3D rendering of human cell. anusorn nakdee / iStock / Getty Images Plus Tissue-resident memory T cells (TRM cells) have emerged as one of the immune system’s most powerful front-line defenders. Unlike circulating T cells that patrol the bloodstream, TRM cells embed within organs—such as the lung, liver, skin, and brain—where they can respond immediately to infection, cancer, or tissue injury. In many cancers, high densities of TRM cells correlate with better survival, and in chronic infections, their presence can determine whether an organ clears or tolerates a pathogen. Yet despite their importance, the molecular cues that instruct a…

Probi has extended its portfolio with two new categories: “Sports & Active Nutrition by Probi” and “Pets by Probi.” As part of this move, the biotics solutions specialist is entering the pet supplement market with the launch of two scientifically backed probiotic solutions targeting digestive and oral health for dogs and cats. Within Sports & Active Nutrition by Probi, the company offers a probiotic solution using the strain Lactiplantibacillus plantarum 299V (LP299V). Based on research, the company claims this strain supports overall physical performance, including cardio-respiratory function, digestive comfort during exercise, circulatory health, endurance, and vitality.“Everyday performance starts in the…

The MaskBruno J. Strasser & Thomas Schlich Yale Univ. Press (2025)“Masks have signified hope and despair, courage and cowardice, a sense of community and a sense of selfishness.” All of these emotions — known to those who experienced the COVID-19 pandemic — underpin this engrossing, finely illustrated account by historians Bruno Strasser and Thomas Schlich (who was previously a physician). Their discussions cover theatrical performances in ancient Greece, plagues and gas attacks in the First World War and present-day urban smog and surgery, while addressing the crucial issue of mask efficacy.The Maya MythsMallory E. Matsumoto Thames & Hudson (2025)Deciphering Mesoamerica’s…