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Credit: Christoph Burgstedt/Science Photo Library/Getty Images Takeda announced last week that it would acquire at least two late-stage oncology candidates, IBI363 and IBI34, for $1.2 billion from China’s Innovent Biologics. Takeda will have worldwide commercialization rights outside of Greater China. With milestones, the deal offers an additional up-to-$10.2 billion for Innovent, making it possibly one of the largest biotech partnerships of the year.  Both drug candidates are antibody-drug conjugates (ADCs) that target hard-to-treat cancers. IBI363 is a potential first-in-class PD-1/IL-2α-bias bispecific antibody fusion protein being evaluated in non-small cell lung and colorectal cancers. IBI343 is a “next-generation” investigational ADC that…

One of HBC’s products is OmeGo, a fish oil comprising the full spectrum of fatty acids and omegas found naturally in fresh whole salmon. (William DondyK/Getty Images)Norwegian company Hofseth BioCare ASA (HBC)’s recently appointed Head of New Business Development has identified product differentiation as a key priority in driving growth for the company. In September, the company appointed Paul Bruhn who has over 25 years of experience in the healthcare and medical nutrition space spanning Novartis Medical Nutrition and Nestlé Health Science, as its Head of New Business Development. With portfolios spanning across bioactive peptides and collagen, fish oil, and…

A new recombinant antivenom that targets multiple venomous snake species—including the African spitting cobra, shown here—could lead to both safer and more effective snake bite treatments.Image credit:© iStock, Craig CordierFrom rubber tappers in Liberia to sugar cane farmers in South Africa, bites from venomous snakes are a constant worry.1 In sub-Saharan Africa—which is home to green and black mambas, spitting cobras, and vipers—more than 300,000 snake bites occur every year.2 Since many of these bites occur in remote areas, the reported greater than 7,000 deaths and 10,000 amputations annually are likely underestimates.While antivenoms are available and effective at treating bites…

New research sheds light on the long-term effects of the ketogenic diet, raising important questions about its safety and efficacy for improving metabolic health. Historically, the ketogenic diet treated epilepsy. It has recently gained popularity for weight loss and management of conditions like obesity and type 2 diabetes.The new mouse-model study suggests that the diet can potentially have dangerous impacts on metabolic health, including how the body processes fats and carbohydrates.“We’ve seen short-term studies and those just looking at weight, but not really any studies looking at what happens over the longer term or with other facets of metabolic health,”…

Valerie Bertinelli does 50 morning jumps to boost energy and blood flow.Jumping may support bone density, and exercise may help improve overall vascular health.Experts say consistency and enjoyment matter most in any morning movement routine. Celebrities have been sharing their morning routines with EatingWell for quite some time, and something we hear often is how much celebs like to get outside when starting their day. From Elizabeth Banks’s morning dog walks to Kelsea Ballerini’s coffee time on her porch, things like morning light and time spent in nature can be really good for you, so it’s no surprise that fresh…

Apple pie and pumpkin pie are likely to have the same impact on blood sugar. While their carbs and fiber are similar, apple pie has less sugar and pumpkin pie has more protein.To enjoy the holiday foods you love and keep blood sugar in check, stick with small servings. Picture this: Thanksgiving dinner is over, and now it’s time for dessert. There are two classic pies on the table, apple and pumpkin. Which one do you choose if you’re watching your blood sugar? There’s no single “right” answer, as each has its nutritional pros and cons. But when you put them…

Surgery is sometimes necessary to remove growths or cysts from vocal cords.Credit: Garo/Phanie/Science Photo LibraryInspired by the world’s largest land animal, researchers have created and tested what they say is the world’s smallest 3D bioprinter. The device — which sports a 2.7-millimetre-wide printhead at the end of a long, flexible arm that moves like an elephant’s trunk — might one day assist physicians by delivering healing hydrogels after surgery.In a report published on 29 October in the journal Device1, the researchers proved that the device could be fed through a physician’s surgical scope to deposit hydrogel onto an artificial set…

Luke TaylorRio de JaneiroEight countries have been added to the UK’s watchlist advising travellers of nations with a high risk of methanol poisoning.The update from the Foreign, Commonwealth, and Development Office (FCDO) follows an increase in the number of UK travellers dying from drinking counterfeit or adulterated alcohol.1The FCDO added Ecuador, Japan, Kenya, Mexico, Nigeria, Peru, Russia, and Uganda to its list. They join Cambodia, Costa Rica, Fiji, Indonesia, Laos, Thailand, Turkey, and Vietnam. The FCDO has also launched an advertising campaign to advise people from the UK to look out for symptoms such as sudden dizziness, nausea, or blurry…

Credit: SCIEPRO/GettyImages A new artificial intelligence-powered platform developed at the European Molecular Biology Laboratory (EMBL) in Heidelberg is offering insight into how chromosomal abnormalities arise in cancer biology. The tool, called MAGIC (machine learning-assisted genomics and imaging convergence), was created by researchers in Jan Korbel’s group at EMBL Heidelberg and published in a new Nature paper. MAGIC is an autonomously operated platform that integrates live-cell imaging of micronucleated cells, machine learning on the fly, and single-cell genomics to systematically investigate cancer formation. It enables scientists to track how spontaneous errors occur during cell division—errors that can set the stage for…

Credit: Henrik5000/Getty Images Using a combination for spatial, single-cell transcriptomics and imaging data from 36 hearts, scientists from the KTH Royal Institute of Technology and their collaborators have come up with what they describe as the “most comprehensive spatiotemporal atlas of first-trimester human heart development to date.” Full details are provided in a Nature Genetics paper published this week that is titled “Spatiotemporal gene expression and cellular dynamics of the developing human heart.” Their work provides a blueprint of the developing heart during the late first and early second trimesters that shows how different groups of cells are arranged and…