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Former Genentech, GRAIL execs form new diagnostics company powered by tissue-level biology, with longevity in its sights. Diagnostics startup Curve Biosciences today announced it has raised $40 million to advance the development and commercialization of its “whole-body intelligence” platform, a technology designed to transform how chronic diseases are detected and monitored. Led by former execs from biotech and diagnostics companies including Genentech and GRAIL, the San Mateo-based company has built what it describes as the first molecular blueprint of the human body. Dubbed the Whole-Body Atlas, Curve’s platform is based on more than 400,000 manually curated tissue samples characterized by…

Joo, K. et al. High performance package-level EMI shielding of Ag epoxy composites with spray method for high frequency FCBGA package application. In Proc. 2018 IEEE 20th Electronics Packaging Technology Conference (EPTC) 674–680 (IEEE, 2018).Erickson, S. & Sakaguchi, M. Application of package-level high-performance EMI shield material with a novel nozzleless spray coating technology. In Proc. 2020 IEEE 70th Electronic Components and Technology Conference (ECTC) 1691–1696 (IEEE, 2020).Zwenger, C. Enabling the 5G RF front-end module evolution with the DSMBGA package. Chip Scale Rev. 25, 26–33 (2021). Google Scholar  Zhang, X., Zhang, B. & Sun, R. Effective conformal EMI shielding coating for…

Magnesium plays a role in hundreds of bodily functions that affect everything from energy production to cardiovascular function. “Magnesium supports so many essential functions: muscle and nerve activity, heart rhythm, blood sugar control, and sleep regulation,” says Raj Dasgupta, MD, an associate professor of clinical medicine at the University of California, Riverside, School of Medicine. “Some research even links it to lower blood pressure and better mood.”[1]Research on magnesium’s health benefits is robust overall, says Ashley Koff, RD, founder of The Better Nutrition Program. That said, studies can sometimes focus on specific forms of magnesium that companies choose to fund,…

Older individuals more susceptible to infection and less protected by vaccination. Changes in immune cell behavior due to aging may be why.Image credit:© iStock, Jacob WackerhausenThe human immune system wanes over time, making older individuals more susceptible to infection and less protected by vaccination.1 However, while this phenomenon is readily visible and acknowledged, why it occurs or what precisely is happening remains unclear. Researchers from the Allen Institute are aiming to fill this knowledge gap. In a study recently published in Nature, they profiled how immune cells change over the course of a human lifespan, discovering that T cells in…

Teva Pharmaceuticals recalls 1-milligram, 2-milligram and 5-milligram Prazosin hydrochloride capsules. This is due to the medication containing high levels of carcinogenic impurity N-nitroso Prazosin C.While risk is low, replace your recalled blood pressure medication and talk to a healthcare provider. There’s an active recall on blood pressure medication prescribed and sold nationwide, according to the U.S. Food and Drug Administration (FDA). This is due to high levels of “N-nitroso Prazosin impurity C” in the medication, which is a potential carcinogenic substance. The recall applies to 1-milligram, 2-milligram and 5-milligram capsules of Prazosin hydrochloride, which is commonly prescribed to those as a…

The name Saanroo comes from the Tamil word “sanru”, which is said to translate to ‘Proof, Testimony, Evidence.’ The company’s founders originate from Tamil Nadu, a state in India where Tamil is spoken. The alternate spelling and additional vowels are intended to improve the pronunciation and memorability. “Saanroo represents the next chapter in our journey—a brand built on proof, not promises,” said John Quilter, CEO of Saanroo. “Our mission is simple yet powerful: to help people live longer, healthier lives through wellness that is truly proven.”While the company’s nutraceutical division transitions to Saanroo, Gencor Pacific will continue to operate as…

The manufacturers of the painkiller Tylenol (acetaminophen; paracetamol in the UK) are being sued over allegations that they hid unproven links between the drug and autism in children from pregnant women.Ken Paxton, attorney general of the US state of Texas and a supporter of President Donald Trump, sued both the well known drug maker Johnson & Johnson (J&J) and Kenvue, a J&J spin-off that has manufactured Tylenol since 2023.“Johnson & Johnson willfully ignored and attempted to silence the science that prenatal and early-childhood exposure to …

Credit: Mohammed Haneefa Nizamudeen / iStock / Getty Images Plus Researchers at the University of California San Diego (UCSD) School of Medicine have leveraged bioinformatics to identify a potential new treatment for spinal cord injury (SCI). Using a computational platform to match gene expression patterns linked to neural regeneration with thousands of known drugs, the team identified thiorphan, the active metabolite in the drug racecadotril for treating gastrointestinal disorders, as a promising candidate for restoring function after SCI. The research is published in the journal Nature. “We were very happy to see that a drug that worked on cells in…

At the ongoing CPHI trade show in Frankfurt, Germany (October 28–30), the nutraceutical and pharmaceutical industries are showcasing their innovations to improve human health, from active ingredients to excipients, delivery systems, and finished products. Gelatin and collagen peptide specialist Gelita is highlighting how its pharma-grade excipients and softgel gelatins are “shaping the next generation of delivery systems.” On the showroom floor, Nutrition Insight meets with Oliver Wolf, global product promotion at Gelita, to discuss the company’s innovations. “Our focus is on performance, safety, and functionality — especially for brands moving toward pharmaceutical-grade products.”“These innovations show how Gelita bridges the gap between food…

Statistical analysisUnless otherwise stated, we used the following system to indicate significance levels in the figure panels: *P < 0.05; **P < 0.01; ***P < 0.001. Statistical tests used are indicated in the main text or figure caption, with specific tests for chromosome biases and breakpoint as well as SCE locations detailed in the Supplementary Methods.Cell culture and cell line developmentMCF10A (CRL-10317, American Type Culture Collection) and RPE-1 (CRL-4000, American Type Culture Collection) cell line and their TP53−/− derivatives were cultured at 37 °C with 5% CO2 atmosphere and 100% humidity, in DMEM/F12 medium (1:1) without phenol red (Gibco), supplemented as follows: RPE-1 medium was further supplemented with…