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Neuroendocrinologist Catherine Woolley and her team at Northwestern University were studying synaptic modulation in female mice when they ran into some trouble. They were attempting to replicate experiments that had been done in male mice, but the researchers soon realized that they couldn’t.“Since then, I’ve come to think that sex differences in the brain could be very important, less for figuring out how our minds work, and more for ensuring that we maximize the benefits of science for medicine,” said Woolley in a Presidential Special Lecture at the 2025 Society for Neuroscience Meeting.For years, neuroscientists thought that studying female animals…

Some people are turning to Reddit to find out if there are foods to avoid while taking statins.Except for grapefruit and grapefruit juice, strictly avoiding certain foods isn’t necessary.Instead, focus on a balanced, heart-healthy eating plan low in saturated fat and added sugars. At some point, we’ve all probably turned to the internet to answer questions about what to eat. Especially if you’re living with a chronic health condition that requires medication, like high cholesterol. For many of us, Reddit is a go-to. Like earlier this year, when one user asked if people taking statins have to strictly avoid certain…

This author describes what it is like to live with chronic hemiplegic migraine, and her search for supportIt took decades for me to receive a diagnosis of chronic migraine, hemiplegic phenotype, with severe aura. My symptoms include tinnitus, upset tummy, severe pins and needles, spreading numbness, hyperacusis, photophobia, reduced cognition, nausea,partial and total paralysis, and muscle weakness.They can be triggered by harsh lighting, strong smells (especially perfume), touch, sudden movements, loud noises, or chaotic environments.Myfirst partial paralysis was in 1991. A few years later I started to experience daily periods of paralysis that left me unable to get out of…

This roasted fennel and farro salad is quick, seasonal and plant-based.Jennifer Garner skips olives but keeps it colorful with pomegranate and thyme.The dish comes together in under an hour with minimal stovetop time. As wonderful as it is to put time and effort into complex, difficult recipes to wow your guests during the holidays, sometimes it really pays to have some easier holiday recipes up your sleeve. After all, we’re not all professional chefs. Lucky for us, actress Jennifer Garner has posted an easy, speedy side dish on her Instagram, just in time for Thanksgiving. This roasted fennel and farro…

Virgos, as the natural planners and overthinkers of the zodiac, Bly notes you need to actually kick back, relax, and enjoy one of your well-planned trips. “Although you love to think through every detail, organize a trip that provides you with opportunities to roam free of an itinerary for a change,” she suggests, adding, “A perfect vacation would be a trip to Italy, where you can explore the beautiful streets, wander into shops, and take in the beauty of the city.”

RESEARCH BRIEFINGS 19 November 2025 Genome-wide association studies and rare-variant burden tests are the two main tools for discovering links between genetic variants and traits. Comparisons of their results reveal that they systematically rank genes differently, and models have been developed to explain why. Ultimately, both methods are complementary, each highlighting distinct aspects of trait biology.

With the new moon in your sign, Scorpio, this is your moment! It is your birthday season, after all, and this new moon arrives like an annual check-in for you. The sun has been in your first house of self and identity for the past few weeks, and with just a few days left in Scorpio season, the moon is meeting up with it.

Fly husbandry and stocksFlies were reared on a standard cornmeal medium at 25 °C under a 12-h–12-h light–dark cycle. To enhance transgene expression levels, flies from all genetic perturbation experiments, including control groups, were shifted to 29 °C shortly before puparium formation. Detailed genotypes for each experiment are listed in Supplementary Table 1.Molecular cloning and generation of transgenic fliesTo generate QF2 lines, we used pENTR/D-TOPO vectors with various enhancer insertions (gifts from the laboratory of G. Rubin) as entry vectors for Gateway cloning into the pBPQF2Uw vector using LR Clonase II Enzyme mix (Invitrogen, 11791020). pBPQF2Uw was made using NEBuilder HiFi DNA…

Credit: miniseries / iStock / Getty Images Plus Using artificial intelligence as a discovery tool, researchers have discovered that the hormone melatonin could offer protection against both aging and Alzheimer’s disease (AD). They say their study sets out a reproducible “AI-to-clinic” paradigm that can provide breakthroughs towards clinically effective therapeutics targeting the intertwined complexities of aging and AD. The findings demonstrate how sophisticated computational frameworks such as machine learning, deep learning, and network-based analytics can systematically mine and interpret vast genomic, transcriptomic, and pharmacological datasets to revolutionize drug discovery. “Our AI-driven methodological framework offers a transformative approach to overcoming traditional…

Biohacking isn’t just for the boys.