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Credit: Salah Uddin/ iStock / Getty Images Plus Researchers at the University of Michigan have incorporated an RNA-based fusion assay into their standard next-generation sequencing (NGS) panel for acute myeloid leukemia (AML), in order to detect gene rearrangements that cytogenetics often miss. The added element is a probe-ligation–based targeted gene fusion assay that is designed to identify 112 gene fusions that are known to be associated with leukemia. “We wanted to have the ability to detect gene fusion, especially since now we know that a decent proportion of them are cryptic and missed by routine cytogenetic practice,” said lead author…
The affiliation of the first author in this article by Krista Kruja and colleagues (BMJ 2025;391:e086516; doi:10.1136/BMJ-2025-086516) was incorrectly given as WHO Regional Office for Europe. The online version has been corrected.
Migraine is one of the most prevalent health conditions in the world, yet it’s often misunderstood and even stigmatized. Part of the problem is its “invisible” nature; since others can’t see the pain, it’s easy to minimize the condition as “just a headache.”That’s why it’s so important to not only learn more about headache and migraine disorders but be in regular contact with others who understand what you’re going through. These organizations can help you do just that.Some offer educational materials and assist in finding doctors or clinics that specialize in migraine and headache care, while others host forums, support…
RNA and protein expression profiles differ between the brains of living and deceased people.Image credit:©iStock.com, antoniokhrOmics technologies have enabled researchers to study the molecular functions of human tissues. But some tissues—like the brain—are harder to access than others. Because of the limited access to living brain samples, scientists studying this organ have relied upon postmortem tissues.Concerned about whether deceased brain tissue adequately resembles living brains, psychiatrist Alexander Charney and neurosurgeon Brian Kopell at the Icahn School of Medicine at Mount Sinai teamed up to investigate this question. As part of the Living Brain Project, they developed a process to retrieve…
Costco recalls Caesar salad and chicken sandwich products sold at select locations.This recall is due to a plastic contamination in the Caesar salad dressing packaged with both lunch items.Dispose or return recalled items; seek medical help if symptoms occur. Costco just announced a recall on two popular ready-to-eat items, according to a recent company letter. This is due to a potential foreign matter contamination. The products affected are the Caesar Salad and Chicken Sandwich with Caesar Salad supplied by Ventura Foods. These recalled lunches have respective item codes “#19927” and “#11444” and have printed sell-by dates ranging from October 17…
When Calvin Santiago Lee decided to look beyond his home in the United States for a PhD position, finances played a decisive part. “I believed that unless I got extremely lucky in the US, there would be little chance of being financially stable during my PhD and having good career prospects thereafter,” says the theoretical computer scientist.The global PhD landscape 2025His current position working on category theory — a mathematical field related to programming languages and logic — at Reykjavik University in Iceland pays well and provides good work–life balance. “I feel like a valued member of society and can…
These tasty low-calorie snack recipes are the perfect satisfying bites that will help keep you full in between meals. With at least seven grams or protein and/or three grams of fiber per serving, these snacks can help support healthy weight loss. So set aside ten minutes and make our High-Protein Caesar Dip or our Goat Cheese-Tomato Toast for a delicious bite that you’ll want to make again and again. Love these recipes? Join MyRecipes to save them all with one click. It’s so easy—and free! Everything Bagel Cottage Cheese Snack Jar with Bell Peppers & Chickpeas Photographer: Jen Causey, Food…
The new space was announced as part of a “strategic expansion” of the company’s R&D footprint to work on its next generation of ingredients. Biohm, a microbiome-focused research and product company, currently holds two ingredients in its portfolio: Mycohsa, a probiotic blend that combines bacterial and fungal communities with a digestive enzyme to encourage gut microbiome balance, and Phorum, a postbiotic that also contains bacteria and fungi to support immune function.The addition of the lab space will allow for the development of new probiotic and postbiotic strains through its Symbiont platform, Kristin Wilhoyte, vice president of marketing at Biohm, told…
Credit: Steve Gschmeissner / Science Photo Library / Brand X Pictures “I’ve fallen and I can’t get up.” We’ve all seen the infomercial: an elderly person, alone, fallen, unable to reach a phone—an image turned into a selling point for a pendant-style SOS device. But for millions of people living with osteoporosis or age-related loss of bone mineral density (BMD), that dramatized moment is uncomfortably real. Ben Swanson, DDS, PhD, imagines a future where that device isn’t needed at all—not because help arrives faster, but because people stay on their feet, aging without the burden of fragile, fracture-prone bones. That…
Drugs such as Ozempic and Mounjaro act on GLP-1 receptors in the brain to regulate appetite. Credit: Oliver Berg/dpa via AlamyThe obesity drug tirzepatide, sold as Mounjaro or Zepbound, can suppress patterns of brain activity associated with food cravings, a study suggests. Researchers measured the changing electrical signals in the brain of a person with severe obesity who had experienced persistent ‘food noise’ — intrusive, compulsive thoughts about eating — shortly after the individual began taking the medication.The study is the first to use electrodes to directly measure how blockbuster obesity drugs that mimic the hormone GLP-1 affect brain activity…