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Last year, Google DeepMind made headlines for building an artificial-intelligence system that achieved a silver-medal standard on the problems from that year’s International Mathematics Olympiad (IMO), a prestigious competition for young mathematicians held annually. It was the first time such a system had performed at a medal-worthy level in solving IMO challenges. Now, writing in Nature, Hubert et al.1 report the details of the core technology behind that achievement: a tool called AlphaProof, which is designed to prove mathematical statements. Competing Interests The author declares no competing interests.

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AbstractObjective To compare the effect on health outcomes of continuing or discontinuing oral anticoagulants (OACs) among patients with unprovoked venous thromboembolism (VTE) after initial treatment for at least 90 days.Design Target trial emulation.Setting Optum Clinformatics Data Mart (Optum CDM) from 1 January 2009 to 28 Februray 2025, and Medicare fee-for-service claims from 1 January 2009 to 31 December 2022, United States.Participants Adults with VTE aged ≥18 years (Optum CDM) or ≥65 years (Medicare) initiating OACs (warfarin or direct OACs) within 30 days after a first hospital admission with VTE without reversible provoking factors and who continued treatment for ≥90 days.…

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Cell-free DNA released into circulation reveals disease processes and pathogens behind sepsis.Image credit: © iStock, solarsevenWhen cells in the body die, they release DNA. This DNA, known as cell-free DNA (cfDNA), makes its way into the bloodstream where it gets chopped up by enzymes, and in minutes to hours, the liver pulls it out of circulation. It can serve as a biomarker in many contexts such as detecting pregnancy complications, organ transplant rejection, and cancer before symptoms appear. Now, in a recent study published in Cell Genomics, scientists in Julian Knight’s lab at the University of Oxford turned to cfDNA to…

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Whether you truly need or just want a new pair of walking or running shoes, now is the time to add to cart. The American Academy of Podiatric Sports Medicine says your running shoes lose their cushioning and shock support after 300 to 500 miles of wear, if you need more convincing to shop.  Many retailers—like REI, Lululemon and Zappos—have already added some highly coveted brands and styles to their sale sections. Shop the best overall deals below and then keep scrolling for even more early Black Friday deals on walking and running shoes. Best Early Black Friday Deals on…

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Snack bars, yogurts, ice cream, even bottled water: it seems like food makers have worked out ways to slip extra protein into just about anything as they seek to capitalize on a growing consumer trend.Today, protein-fortified foods and protein supplements form a market worth tens of billions of US dollars, with fitness influencers, as well as some researchers and physicians, promoting high-protein diets as the secret to strength and longevity. Protein is undeniably essential, but how much people really need is still a topic of debate.What humanity should eat to stay healthy and save the planetOn the one hand, most…

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A new study has experts cautiously excited about the potential benefits of vitamin D supplementation for people living with heart disease.Results from a preliminary trial found that heart attack survivors who received personalized doses of vitamin D were more than 50 percent less likely to have a repeat heart attack, compared with people who did not follow this regimen but got standard treatment.[1]“I think people are opening their minds to the concept that vitamin D might be something that is good for heart health,” says Heidi T. May, PhD, the study’s principal author and an epidemiologist and professor of research at…

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Credit: humonia / iStock / Getty Images Plus Ultrasound-created microbubbles can deliver anti-cancer drugs to tumors in difficult-to-reach areas such as the brain stem and spinal cord, a pilot study in children has revealed. The microbubbles provide a potential entry point for treatments aimed at the central nervous system that are not usually able to traverse the blood-brain barrier. Focused ultrasound (FUS) radiation temporarily opened this naturally protective barrier, which is designed to filter out molecules above a certain size to prevent toxins and infectious agents from reaching functional brain tissue. The technique excited microscopic particles called microbubbles, causing them…

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The leadership of the US Department of Health & Human Services is pushing the U.S. Food and Drug Administration to explore the elimination of self-affirmed GRAS (General Recognized as Safe) for food ingredients. The government shutdown meant the agency’s own deadline of October to announce proposals came and went, but the proposals will arrive once the government reopens. “Everybody’s concerned, obviously, and it doesn’t only affect probiotics, it affects the entire supplement space,” Paraskevakos, IPA’s executive director, told NutraIngredients at the recent SupplySide Global in Las Vegas. “So, we’ve been very active, proactive. Our regulatory affairs committee is pretty huge,…

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You have full access to this article via your institution. People wade through Mumbai’s flooded streets during monsoon rains in August.Credit: Indranil Aditya/NurPhoto/GettyThe monsoon season lasts from June to September in southern Asia. During this period, nearly 60% of Bangladesh’s population is at risk from floods. Last year, some five million people were affected by flash floods caused by heavy rains. Increasingly heavy rains are submerging parts of India and Pakistan, too. This year alone, 45% of India has experienced extreme rainfall, leading to some 1,500 deaths. And, in Pakistan, two million people have had to evacuate their homes and…

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