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Klotho Neurosciences CEO on why Klotho’s role in aging makes it more than a longevity gene – and why ALS may prove its most telling test. Klotho has long fascinated scientists of aging. First identified in mice where overexpression extended lifespan and loss of function led to premature decline, Klotho exerts influence across multiple systems – kidney, brain, muscle, even cardiovascular tissue – and its decline with age has made it a compelling candidate in the search for therapeutic ways to sustain healthspan. From this biology emerged Klotho Neurosciences, a company aiming to turn that fascination into clinical reality. Its…

The road to a first-author paper often isn’t short or direct.Credit: Grant Ordelheide/Aurora Photos/GettyAs a fifth-year PhD candidate, I have a degree in not getting enough sleep and an unhealthy habit of scrolling through LinkedIn. My feed is a relentless highlight of everyone else’s successes: papers, major grants, coveted fellowships. And then there’s me, in a five-year-long, committed relationship with a massive project, in the field of neuroscience.It’s not that I haven’t published anything. My name appears on co-authored papers that I’m proud of, collaborations in which I contributed data, analyses and expertise. But my own project was structured as…

A consultant pathologist has been suspended from the UK medical register for 12 months after spilling beer on a junior female colleague’s cleavage at a work party and licking it off her breasts.Mark Johnson also sent derogatory and sexually demeaning text messages to the same woman about other colleagues, a tribunal found.In a case where General Medical Council (GMC) lawyers argued for erasure, the tribunal found that several other allegations of sexual harassment stemming from the same party—at which most of the witnesses acknowledged drinking heavily—were not proved.The main witness against Johnson was an administrative assistant named only as Ms…

Four Cardio Machines for Your AbsEllipticals, treadmills, stationary bikes, and rowing machines can help you increase your heart rate and get a great cardiovascular workout while using them.But you’ll be working your abdominal muscles at the same time. This is because to use these machines, you engage your core muscles. And a strong, stable core helps you more easily take on everyday activities.[1]1. Stationary BikeDoes the stationary bike work your abs directly? It can. When cycling, your core stabilizes your pelvis and keeps your hips square in your seat.[2]2. EllipticalDon’t bypass the elliptical machine the next time you hit the…

These cheese straws come together with just three simple ingredients. Parmigiano-Reggiano provides a source of protein and satiety to these crispy cheese straws. You can make these straws ahead of time, so they’re perfect for holiday parties. These Puff Pastry Cheese Straws are a party classic that never gets old. Buttery layers of puff pastry are twisted with Parmesan cheese and garlic, baking into airy, crunchy straws that are as fun to eat as they are to serve. The best part? They’re remarkably simple to prepare ahead—assemble and chill on a baking sheet, then pop them in the oven just before guests…

Boston — “If we want to treat and cure all disease, that will require enabling genetic agency,” said Eric Kelsic, PhD, co-founder and CEO of Dyno Therapeutics, in an interview with GEN. “AI will have a key role to make that possible by democratizing design.” Kelsic defines genetic agency as a person’s ability to take action at the genetic level to live a healthier life. The term highlights the importance of creating therapeutic options where none exist and recognizes the advocacy efforts of patients and their families.  In support of this vision, Dyno hosted the inaugural Genetic Agency Technology Conference (GATC) in Boston, which gathered a group of researchers, technologists,…

The buttery and delicate taste of cheese shines bright in these vegetable side dishes. From creamy casseroles to crispy Parmesan-crusted veggies, you’re sure to find a healthy, melty and cheesy recipe you’ll enjoy. Plus, with four- and five-star ratings from EatingWell members, recipes like our French Onion Smashed Potatoes and Cheesy Pull-Apart Cauliflower with Marinara are guaranteed to become regular favorites in your home. Love these recipes? Join MyRecipes to save them all with one click. It’s so easy—and free! French Onion–Stuffed Mushroom Bites Photographer: Brittney Cottrell, Food stylist: Isabelle Easter, Prop Stylist: Keoshia McGhee. Inspired by classic French onion…

How’s this for an academic dream team? Albert Einstein, Niels Bohr and Richard Feynman. The three physicists and I often get together over coffee to chat about career decisions, difficulties and dilemmas. Of course, not the real Einstein, Bohr and Feynman — the last of the trio to die was Feynman, in 1988 — but rather, simulations of the three that I have assembled, using artificial intelligence (AI), to serve as my personal advisory board.AI is seemingly everywhere these days. It’s in productivity apps, web browsers and technical support lines. AI users increasingly report developing friendships, and even romantic relationships,…

Credit: Christoph Bock/Wikimedia Commons High-performance enzyme engineering company Watchmaker Genomics recently launched TAPS+, a novel technology that allows for simultaneous detection of methylation and genetic variants using a single sample. The chemistry enables simultaneous detection of methylation (5mC), single-nucleotide variants (SNVs), insertions and deletions (indels), and copy number variations (CNVs) from the same DNA molecule. This multimodal approach has broad applications in oncology ranging from early disease detection to therapy response and minimal residual disease detection. Current methylation analysis typically leverage bisulfite, which converts unmethylated cytosines to thymines, reducing the four-base sequence (ATCG) to three bases. But this method is…

Exploring the crossroads of genetics and imaging, this postdoc investigates how cellular disarray leads to malignancy.Image credit:UW Office of Postdoctoral Affairs, ©iStock, DlumenQ | Write a brief introduction to yourself including the lab you work in and your research background. My name is Umar Sheikh and I am a cancer biologist in the McArdle Laboratory for Cancer Research at the University of Wisconsin–Madison. My research spans cancer genomics, UVB photobiology, and the role of planar cell polarity loss in melanoma. I also investigate MmuPV1–estrogen interactions in cervical cancer using molecular and computational -omics approaches.Q | How did you first get…