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View eBook   A number of blockbuster biologics worth $200 billion in revenue are expected to lose patent exclusivity by 2030 (1), which presents biosimilar manufacturers a huge opportunity for producing drugs at a much lower cost. However, to gain a foothold in the market, biosimilar developers must consider their manufacturing approach in terms of not only speed to market, but manufacturing efficiency and production costs. In fact, the cost of consumables routinely make up a significant portion of the ongoing manufacturing costs for an approved biosimilar. Consumables, such as resins, filters, and media, impact production costs and can increase…

People who are severely obese often have lower levels of the amino acid, glycine, compared to people of healthy weight, as their body typically cannot synthesise enough glycine to meet the metabolic demand. Glycine is essential for detoxification, antioxidant protection, and energy metabolism. In severely obese people, low glycine levels may accelerate oxidative stress, resulting in a higher risk of developing certain diseases such as type 2 diabetes mellitus, and Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD), a condition caused by excessive fat in the liver.Hence, researchers wanted to study if glycine supplementation can correct glycine deficiency in individuals with severe…

Ina Garten shares a favorite recipe from Missy Robbins, a New York City chef and restaurant owner.It’s a quick and easy baked ricotta recipe that’s flavorful and ideal for holiday entertaining.To achieve the best flavor and texture, it is important to use authentic artisanal ricotta. Ina has graciously shared so many of her cooking secrets with us, from making better soups to a versatile vinaigrette. And, of course, she’s always been there for us ahead of the holidays, giving us a sneak peek into what she’ll be serving. While she has plenty of her own recipes, Ina is also not…

Blending chemistry, computation, and curiosity, one postdoc studies how molecular motion shapes the durability of everyday materials.Image credit:Pierre Kawak, ©iStock, imaginimaQ | Write a brief introduction to yourself including the lab you work in and your research background. I’m Pierre Kawak, a chemical engineer by training and postdoc in Simmons Lab at the University of South Florida. I was raised and educated in the Middle East. I use simulations and polymer physics to see how plastics move, stick, and break—making nanoparticle-reinforced rubber tougher and tuning polymer sequences to control brittleness.Q | How did you first get interested in science and/or…

What you drink can negatively or positively affect your blood sugar.Many drinks contain sources of sugar that can spike blood sugar and then send it crashing.The best no-added-sugar drinks include coffee, tea, sparkling water, infused water and milk. When it comes to choosing a beverage, the options are endless—but many drinks contain sneaky sugars that can impact your blood glucose levels. Even some beverages with no added sugar may still contain carbohydrates that can cause your blood sugar to rise. Navigating the beverage aisle takes a bit of skill, so we’ve enlisted a few dietitians to share their top five…

Credit: quantic69 / iStock / Getty Images Plus I’ve been poring over the news around Intellia Therapeutics’ NTLA-2001, an in vivo CRISPR-Cas9 therapy to inactivate the TTR gene in two sets of transthyretin amyloidosis patients. On October 27, 2025, Intellia reported that an 80-year-old trial participant treated with NTLA-2001, also known as nexiguran ziclumeran (nex-z), had Grade 4 liver transaminases and increased total bilirubin, requiring hospitalization. The FDA placed a clinical hold on NTLA-2001, the 650+-patient MAGNITUDE trial, and MAGNITUDE-2 (NCT06672237), a 47-patient Phase III study, while the company and authorities investigated.   For days, I and others have wondered: What…

The US Department of Agriculture (USDA) has issued a memo claiming states’ actions to provide full Supplemental Nutrition Assistance Program (SNAP) benefits for November were “unauthorized.” The USDA orders states to “immediately undo any steps taken to issue full SNAP benefits for November 2025.” The longest government shutdown in US history halted SNAP benefits, affecting millions of US citizens relying on them for food security. Several states moved toward providing full November SNAP benefits after a Supreme Court administrative stay of a district court order in Rhode Island State Council of Churches v. Rollins, which had required states to resume full…

Elisabeth Perreau-Saussine, fifth year medical studentUniversity College London, UKCorrespondence to: E Perreau-Saussine elisabeth.perreau-saussine.20{at}ucl.ac.ukA golden question for future doctors is whether our role lies solely in treating individual patients or extends to tackling the broader social determinants of health. Each doctor will interpret this responsibility differently, shaped by their sense of social duty. As we navigate medical school, the curriculum helps us to form our response to the tensions between individual and societal medical role issues.Theory and history of the social determinants of healthThe World Health Organization (WHO) defines the social determinants of health as non-medical factors that influence health outcomes.1…

People protested staff cuts at the US Centers for Disease Control and Prevention in March.Credit: Elijah Nouvelage/GettyIn the nine months since anti-vaccine activist Robert F. Kennedy Jr stepped in as US health secretary, all eyes have been on the US Centers for Disease Control and Prevention (CDC), an agency tasked with protecting the health of Americans and which Kennedy had referred to before his appointment as a “cesspool of corruption”. In June, members of the Advisory Committee on Immunization Practices (ACIP), an expert panel that makes recommendations on what vaccines should be considered safe and effective for Americans were dismissed…

Muna Therapeutics targets brain resilience with drug designed to enhance neural health by harnessing established protective mechanisms. Denmark’s Muna Therapeutics has dosed the first participants in a Phase 1 clinical trial of its therapy designed to target early-stage Alzheimer’s disease by enhancing the brain’s innate protective mechanisms. The Copenhagen-based company’s approach focuses on the concept of brain resilience – the ability of the brain to preserve function despite the presence of misfolded protein pathology. Misfolded proteins are a feature of neurodegenerative diseases like Alzheimer’s, accumulating in the brain and forming toxic aggregates that disrupt cellular processes and spread from cell…