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Success rates for Europe’s leading research grants are declining — some to single percentage points — as a surge in applications far outweighs the funds available. Data gathered by Nature show that researchers, especially those at the start of their academic journeys, are facing increasingly fierce competition to pursue research careers (see ‘Funding competition’).Last month, the European Commission said that the European Union’s research and innovation framework programme had received the highest number of funding proposals in its four-decade history this year.Applications for the 2025 Marie Skłodowska-Curie Actions (MSCA) Postdoctoral Fellowships exceeded 17,000 — an increase of nearly 65% compared…

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An ice cream scoop makes hollowing out pumpkins quicker and easier.Thinner pumpkin walls mean smoother, safer carving for your designs.You don’t need to buy extra tools—repurpose what’s already in your kitchen. Fall is, by far, my favorite season. Growing up in the Northeast, the arrival of cooler weather and changing leaves always signaled the start of this magical season full of festive traditions, like apple picking and carving pumpkins for Halloween. The latter is still a favorite, and last year I made a serendipitous discovery: An ice cream scoop makes pumpkin carving so much easier. If you’ve carved pumpkins before,…

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Human karyotype of Down syndrome. Autosomal abnormalities. Trisomy 21. [Rujirat Boonyong/Getty Images] Faulty brain circuits seen in Down syndrome may be caused by the lack of a particular molecule essential for the development and function of the nervous system, according to a new study in lab mice. Restoring the molecule, called pleiotrophin, could improve brain function in Down syndrome and other neurological diseases, possibly even in adults, the researchers say. The scientists conducted their work in mice, rather than in people, so the approach is far from being available as a treatment. But the researchers found that administering pleiotrophin improved…

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Conducted by researchers from Atlantic Technological University, Sport Ireland Institute and Ulster University in Ireland, the report aimed to map current knowledge, identify effective nutrition-based interventions and highlight existing research gaps.“Sleep is a critical pillar of health and elite athletic performance, influencing recovery, adaptation, cognitive function and injury risk,” Professor Sharon Madigan, head of performance nutrition at Sport Ireland Institute, told NutraIngredients. “Despite its recognized importance, the specific role of nutritional strategies to enhance sleep quality and duration in athletes is an emerging field with fragmented evidence. There are lots of views and opinions of which many have no credible…

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Protein shakes, bars and powders can be quick, convenient sources of protein.Yet, many contain ingredients that could age you and increase chronic disease risk.If you do eat them, make them part of an eating plan filled with whole, nutrient-rich foods.  If there’s one nutrition trend that’s sticking around, it’s the high-protein craze. It’s popular for lots of good reasons. Protein is important for muscle, bone and skin health. It also promotes satiety, so it helps with weight management, too. As beneficial as protein is, it comes in a variety of foods. And some of them are better for you than…

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Waters Corporation (NYSE: WAT) today unveiled the Waters Xevo Charge Detection Mass Spectrometer (CDMS), delivering unmatched measurement and characterization for the broadest range of mega-mass biomolecules central to next-generation therapeutics and structural biology. With the rapid growth of cell and gene therapies, mRNA, and complex protein therapeutics, scientists face significant challenges in analyzing increasingly large and heterogeneous drug modalities – yet existing tools are limited in resolution, sensitivity, and compliance-readiness. The Xevo CDMS System addresses these gaps with direct, individual-particle mass measurement for molecules up to 150+ MDa, enabling previously unattainable analysis of protein complexes, nucleic acids, lipid nanoparticles, viral…

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Fluorescent dyes can help researchers to visualize the structure of a cell — but it can be difficult to use more than a handful.Credit: David Becker/SPLWhen working with fluorescent dyes or proteins, researchers typically focus on two variables: the wavelength of light at which the molecules are stimulated to fluoresce, and the wavelengths at which they emit light — that is, their colour. By balancing those properties, researchers can distinguish between half a dozen or so fluorescently tagged molecules in the same sample.But there’s more to fluorescence than colour, and scientists can now more easily use another property of fluorescent…

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