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New research from scientists at Max Planck Institute for Biology of Ageing, Icahn School of Medicine at Mount Sinai, and their collaborators helps elucidate the neuroprotective role of microglia, the innate immune cells of the brain, and points to a possible therapeutic pathway for Alzheimer’s disease. Details of their work are published in a new Nature paper titled “Lymphoid gene expression supports neuroprotective microglia function.”   Using mouse models and human cells and brain tissue, the scientists found that downregulating the transcription factor PU.1 promotes the expression of lymphoid immunoregulatory receptor proteins on microglia. They also found that deleting CD28 from this…

Public healthPoorer health is linked to votes for Reform UKPeople with poorer health are more likely to vote for the populist right wing political party Reform UK, showed a study published in BMJ Open Respiratory Research.1 Researchers analysed voting patterns in England during the 2024 general election and looked at 20 common health outcomes in each constituency, including asthma, cancer, chronic obstructive pulmonary disease, heart disease, dementia, type 2 diabetes, and obesity. The five areas that returned a Reform UK MP had the highest average prevalence of 15 of those 20 health conditions.Prostate cancerNICE approves combination for advanced casesThe National…

As the global population grows and food demand surges, farmers rely heavily on pesticides to boost crop yields and safeguard food quality—practices that have delivered undeniable economic benefits. But these chemicals don’t remain on the farm—they travel through soil, water, and air, reaching humans and other non-target organisms. These widespread exposures raise important questions about how pesticides affect the biological systems that keep us healthy. Increasingly, scientists are uncovering a key player in this story—the gut microbiota, the complex microbial ecosystem that helps regulate metabolism and immunity. Evidence suggests it may be a critical pathway through which pesticide exposure harms…

A picture of Meaghan Kavanagh, a postdoc at the Harvard T.H. Chan School of Public Health.Image credit:©iStock, Beo88Q | Write a brief introduction to yourself including the lab you work in and your research background. My name is Meaghan Kavanagh, and my research focuses on the role of dietary patterns in chronic disease prevention. More simply put, my research focusses on what people eat and how that impacts their risk for diseases, specifically chronic diseases, conditions that differ from infectious diseases and include cardiovascular disease, type 2 diabetes, cancer, metabolic dysfunction–associated steatotic liver disease (MASLD), musculoskeletal diseases, and neurological disorders…

The BC-APPS1 studyThe BC-APPS1 was a single-arm, single-centre phase II study registered under the name ‘a pilot prevention study of the effects of the anti-progestin ulipristal acetate (UA) on surrogate markers of breast cancer risk’ (EudraCT registration number: 2015-001587-19; registration date: 15 July 2015; Greater Manchester-South, Research Ethics Committee number 15/NW/0478). Eligible women were premenopausal, 25–45 years of age with regular menses and a residual lifetime breast cancer risk of at least 17% (≥1:6) assessed by the Tyrer–Cuzick risk estimation programme (v7.02; https://ems-trials.org/riskevaluator/). All women were recruited from the Family History Risk and Prevention Clinic at the Nightingale Centre, Wythenshawe…

Credit: luismmolina / iStock / Getty Images Plus Not all mutations in the tumor suppressor gene TP53 are created equal. That is the finding of researchers at Baylor College of Medicine who have discovered that while mutations in p53 are known to promote cancer, some, such as the p53 R273H mutation, can overstimulate DNA replication in cancer cells, creating genomic instability that activates an immune attack against tumors. Results of the research are published in Communications Biology. “We studied two common p53 mutants, R273H and R175H, in their ability to affect the growth of cancer cell lines in the lab,”…

These holiday recipes all received five star ratings up from our readers, making them the perfect choices to add to your dinner table this Thanksgiving. From the familiar and comforting taste of our Twice-Baked Sweet Potatoes with Marshmallows, to the fresh and tangy flavors of our Broccoli-Apple Crunch Salad, you can save all of these dishes to MyRecipes with just one simple click. Avoid last-minute stress and have tested and approved recipes just a few taps away—you can thank us later. Love these recipes? Join MyRecipes to save them all with one click. It’s so easy—and free! Twice-Baked Sweet Potatoes…

Eating chia seeds in the morning may help with appetite and blood sugar control.Soaking chia seeds boosts fiber benefits and improves digestion.Start with 1 tbsp a day to avoid digestive upset, and drink plenty of water. Tiny but mighty, chia seeds pack nearly 10 grams of fiber in just 2 tablespoons. That fiber supports gut health, stabilizes blood sugar, and may help lower cholesterol—but how and when you eat them matters, say dietitians. “Proper timing, preparation, and hydration optimize chia fiber’s impact on digestion and overall health,” says Raksha Shah, M.A., RDN. Especially if your fiber intake is typically low, you’ll…

Bozsoki, Z. et al. Ligand-recognizing motifs in plant LysM receptors are major determinants of specificity. Science 369, 663–670 (2020).Article  CAS  PubMed  ADS  Google Scholar  Lemmon, M. A. & Schlessinger, J. Cell signaling by receptor tyrosine kinases. Cell 141, 1117–1134 (2010).Article  CAS  PubMed  PubMed Central  Google Scholar  Shiu, S. H. & Bleecker, A. B. Receptor-like kinases from Arabidopsisform a monophyletic gene family related to animal receptor kinases. Proc. Natl Acad. Sci. USA 98, 10763–10768 (2001).Article  CAS  PubMed  PubMed Central  ADS  Google Scholar  Zipfel, C. & Oldroyd, G. E. Plant signalling in symbiosis and immunity. Nature 543, 328–336 (2017).Article  CAS  PubMed  ADS …

Anthony A Laverty, associate professor in public health1, James Nix, vehicles policy manager2, Cleo Kennington, consultant in emergency general surgery and major trauma3, Anna Goodman, assistant professor41Public Health Policy Evaluation Unit, School of Public Health, Imperial College London, London, UK2Transport and Environment, Brussels, Belgium3St George’s Hospital, London, UK4Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UKCorrespondence to A A Laverty a.laverty{at}ic.ac.ukParking policy, taxation, and regulation could help curb sales and health risksSports utility vehicles (SUVs) are passenger cars that have a chassis with extra ground clearance and are generally taller, wider, and heavier than…