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“This is encouraging and suggests that even small, consistent increases in daily activity among sedentary individuals may be meaningful for brain health, although clinical trials will be needed to confirm these observational findings,” says the first study author, Wai-Ying Wendy Yau, MD, a cognitive neurologist at the Mass General Brigham neurology department in Boston.How Many Steps a Day Do You Need to Protect Your Brain?Researchers analyzed health data from about 300 adults between ages 50 and 90 whose brain scans revealed early biological markers of Alzheimer’s disease. At the beginning of the study, they wore pedometers over four to seven…

Credit: hapabapa / Editorial RF / iStock Editorial / Getty Images Plus Thymidine kinase 2 deficiency (TK2d) is an ultra-rare (1.64 cases per 1,000,000 people) often fatal, genetic mitochondrial disease characterized by progressive and severe muscle weakness. Those experiencing initial symptoms on or before the age of 12 years face a high risk of premature death (often occurring within three years after symptom onset). It is a debilitating disease with a severe impact on daily living, including one’s ability to walk, eat, and breathe independently and no previously approved treatment options beyond supportive care. This week, the U.S. Food and…

GWAS summary statisticsGWAS summary statistics for 305 continuous traits were downloaded from the Neale Lab (http://www.nealelab.is/uk-biobank/; v3). These regressions were run on inverse rank normal-transformed phenotypes in a subset of the UK Biobank consisting of approximately 360,000 individuals and included age, age2, inferred sex, age × inferred sex, age2 × inferred sex and principal components 1–20 as covariates. We used 5 × 10−8 as the threshold for genome-wide significance unless otherwise stated.LoF burden test summary statisticsSummary statistics for 292 LoF burden tests were downloaded from Backman et al.4. Two-hundred and nine traits overlapped with traits for which we had GWAS summary data (Supplementary Table 1). Burden…

Bridging nutrition, psychology, and technology, this postdoc aims to reduce the emotional burden of diabetes care.Image credit:Meryem Talbo, ©iStock, DonkeyWorxQ | Write a brief introduction to yourself including the lab you work in and your research background. I am Meryem K. Talbo, a postdoctoral fellow at Stanford University’s School of Medicine. I am also a registered dietitian and nutrition scientist passionate about improving health outcomes for people living with type 1 diabetes and reducing the burden of diabetes management by using technology.Q | How did you first get interested in science and/or your field of research? During my undergraduate studies in human nutrition…

Credit: Christoph Burgstedt/Getty Images A study published today in Nature reveals a unique weakness of metastatic melanoma cells that have spread to the lymph nodes. These cells were found to rely on the ferroptosis suppressor protein 1 (FSP1) to survive, opening the door for new therapeutic strategies against treatment-resistant and metastatic melanoma. Ferroptosis is a form of cell death caused by the accumulation of oxidized lipids on the cell membrane, eventually leading to its rupture. The study found that metastatic cells can adopt different strategies to protect themselves against ferroptosis depending on the location they are spreading to. In particular,…

Speaking with NutraIngredients on Oct. 29 at SupplySide Global in Las Vegas, Dr. Fabricant noted that, to his knowledge, no one at the Office of Dietary Supplement Programs (ODSP) at the U.S. Food and Drug Administration has been labeled essential and are therefore furloughed. This has implications for GMP inspections, although some are ongoing, said Dr. Fabricant, because the FDA has contracted with about 15 states to conduct inspections on behalf of the agency. The shutdown also appears to have affected the Agency’s own deadline of October to announce proposals to amend the Generally Recognized as Safe (GRAS) regulation.“We’ve reached…

Just 5,000–7,500 daily steps may slow Alzheimer’s-related brain changes.Physical activity was tied to slower tau buildup and cognitive decline.Walking more delayed functional decline by up to 51% over 9 years. Alzheimer’s disease (AD) is a condition that many of us worry about as we, or our loved ones, get older. It gradually affects memory, thinking, and the ability to carry out daily tasks. While there’s no cure yet, and there are many risk factors for developing this condition that are out of our control (like our genetics), research suggests that nearly half of all cases worldwide could be linked to…

A five-year review of health records links the long-term use of melatonin supplements with a higher risk of heart failure diagnosis and hospitalization, as well as death from any cause in chronic insomnia. However, experts and industry associations call for “caution and context” in interpreting the preliminary study’s findings on the popular sleep supplement. Although the observational study cannot prove a cause-and-effect relationship, the authors note that it raises safety concerns regarding the use of melatonin and may warrant further research. The complete research will be presented at the American Heart Association’s Scientific Sessions (Nov 7–10) in New Orleans, US. The…

Need inspiration for some quick and nourishing dinners? Try one of these 30-minute dinner recipes! Each of these dishes is loaded with anti-inflammatory ingredients like dark-colored produce, fatty fish and leafy greens to help you combat pesky symptoms of chronic inflammation like joint pain, muscle aches and mental fog. Plus, each serving contains at least 6 grams of fiber alongside probiotic and/or prebiotic foods to meet our gut-healthy parameters. Options like our Lemon-Turmeric Cabbage & White Bean Soup and our Broccoli-Cheddar Butter Beans will help you end your day on a satisfying note.  Love these recipes? Join MyRecipes to save them all…

Billionaire-backed research institute with aging and brain health in its sights closes doors due to ‘policy uncertainty and weak funding.’ Biomedical research institute Arena BioWorks is shutting down after less than two years in operation. The closure comes as persistent macroeconomic and policy challenges continue to weigh heavily on the biotechnology sector. Reportedly funded to the tune of $500 million by a group of high-profile investors that included the likes of Michael Dell, Jim Breyer, Michael Chambers and Elisabeth DeLuca, Arena had sought to merge early-stage scientific research and commercial company creation under one roof. Its founders envisioned a model…