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A doctor sued by Texas state for providing gender affirming care to minors has handed in her licence and moved out of state.Texas’s attorney general, Ken Paxton, filed a lawsuit against May Lau in October 2024 for providing at least 21 adolescents with the hormone testosterone. But Paxton said that despite Lau’s actions he was not dropping the case against her.1“May Lau has done untold damage to children, both physically and psychologically, and the surrendering of her Texas medical licence is a major victory for our state,” he said. “My case against her for breaking the law will continue, and…

AnimalsThis study followed some applicable aspects of the PREPARE89 planning guidelines checklist, such as the formulation of the in vivo study, dialogue between scientists and the animal facility, and quality control of the in vivo components in the study. All animals were born, bred and housed at the Karolinska Institutet, Comparative Medicine Biomedicum animal facility (KMB). Mouse brain tissues (postnatal days P0, P2, P5, P7, P10 and P21) were obtained from a mouse line generated by crossing Sox10:cre animals (The Jackson Laboratory, 025807) on the C57BL/6j genetic background with RCE:loxP (eGFP) animals (The Jackson Laboratory, 32037-JAX) on a C57BL/6xCD1 mixed genetic…

Mouse breeding and husbandryAll experimental procedures related to the use of mice were approved by the Institutional Animal Care and Use Committee of the Allen Institute for Brain Science (AIBS) in accordance with NIH guidelines. Mice were housed in rooms with controlled temperature (21–22 °C) and humidity (40–51%) conditions at no more than five adult animals of the same sex per cage. Mice were provided food and water ad libitum and were maintained on a regular 14:10 h light–dark cycle. Mice were maintained on the C57BL/6J (RRID: IMSR_JAX:000664) background. We excluded any mice with anophthalmia or microphthalmia.The presence of vaginal plugs was…

Credit: Artur Plawgo/Getty Images Preclinical studies by researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, showed how a new combination therapy for hormone-resistant, estrogen receptor-positive (ER+) breast cancer can tackle tumors both in mouse models and in patient-derived explants. The team’s studies suggested that a subtype of immunosuppressive tumor-associated macrophage (TAM) help ER+ breast cancer cells resist hormone therapy. They then showed how blocking these cells using anti-DLL1 and anti-PD-L1 antibodies combined with low dose tamoxifen (TMX) resulted in tumor shrinkage, reduce the number of cancer stem cells (CSCs) and reprogramed the immunosuppressive…

Credit: Md Saiful Islam Khan/Getty Images Investigators at Mass General Brigham have developed a new tumor-fighting strategy that “hijacks” a tumor cells’ innate immune machinery to effectively work against itself. The study, published in the Proceedings of the National Academy of Sciences (PNAS), details a method that induces tumor cells to generate an immune-activating molecule called cyclic GMP-AMP (cGAMP). This reacts to the presence of double-stranded DNA (dsDNA) in the cells’ cytoplasm to activate the immune system to fight the tumor. “Tumor cells comprise a significant proportion of the tumor microenvironment but are often under-utilized for immunotherapy,” said senior author…

United States science always suffers during government shutdowns. Funding lapses send government scientists home without pay. Federal agencies suspend new grant opportunities, place expert review panels on hold, and stop collecting and analyzing critical public datasets that tell us about the economy, the environment and public health.In 2025, the stakes are higher than in past shutdowns.This shutdown arrives at a time of massive upheaval to American science and innovation driven by President Donald Trump’s ongoing attempts to extend executive power and assert political control of scientific institutions.With the shutdown entering its fifth week, and with no end in sight, the…

Starting your day with a glass of water is an easy way to improve digestion.Water stimulates saliva production, prevents constipation and aids in nutrient absorption. Coffee, tea, fruits and veggies can also add more fluids to your morning. Your digestive system is a window into your overall health. It’s not just integral to how you feel before, during and after you eat. It also impacts how your immune system functions, as well as your mood and your cognitive health.  The foods you eat play a key role in your digestive health. Drinks do, too, especially water. Why not start the day…

Shanghai forum brings together international experts as longevity science evolves from measuring decline to testing repair. Six years ago, the inaugural TimePie Longevity Forum gathered a handful of scientists and early advocates in a single seminar room to exchange ideas about the biology of aging; in 2025, the conversation has grown considerably. On 20–21 September, more than 1,500 participants from twenty countries convened in Shanghai for the Forum’s sixth edition, confirming its position as one of Asia’s most energetic longevity meetings. Over two full days, speakers and delegates explored the state of aging science through more than forty presentations. What…

The US health secretary, Robert F Kennedy Jr, has called on the world’s health bodies to “follow America’s lead” and remove mercury from all vaccines.In July the US moved to ban the mercury based preservative thiomersal (known in the US as thimerosal) from all influenza vaccines.1 Kennedy said that the move was to “put safety first.”Before the ban thiomersal was used only in multidose vials of the flu vaccine in the US and …

The human neocortex contains hundreds of types of neurons and glia1 that emerge early in development from what appears to be a more limited set of progenitor types2. Birthdating studies conducted in the 1970s have provided a blueprint for our understanding of cortical neurogenesis by revealing the sequential, inside-out production of cortical layers and subsequent generation of glia3, but were unable to resolve the exact developmental origins of these cells. Clonal lineage tracing studies in model organisms, especially in mice, have increased our understanding of development, revealing that radial glia in the ventricular zone (VZ) of the developing brain act…