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Traditional Alzheimer’s disease diagnostics leave many undiagnosed until their symptoms are advanced. The creators of a noninvasive blood biomarker test hope to change that.Image credit:©iStock, FG TradeDiagnosing Alzheimer’s disease has long relied on expensive and invasive procedures, often delaying care until symptoms are well advanced. With the recent US Food and Drug Administration (FDA) clearance of Fujirebio’s Lumipulse G pTau 217/β-Amyloid 1-42 Plasma Ratio test, clinicians now have access to a simpler, blood-based diagnostic tool for identifying amyloid pathology.Diana Dickson Vice President Clinical and Regulatory Sciences Fujirebio DiagnosticsIn this Innovation Spotlight, Diana Dickson, the vice president of Clinical and Regulatory Sciences…

Sarah E Jackson professorial research fellow, Hazel Cheeseman chief executive officer, Katherine East associate professor in public health, Jamie Brown professor of behavioural science and health Jackson S E, Cheeseman H, East K, Brown J. Vaping misperceptions must be challenged BMJ 2025; 391 :r2117 doi:10.1136/bmj.r2117

Israel and Hamas have agreed to a ceasefire in Gaza and the release of hostages. This is the first phase of US President Donald Trump’s “20-Point Peace Plan.” This news comes as a new publication in The Lancet finds that over 54,600 children in Gaza are acutely malnourished and have few therapeutic options available. Conducted by the UN Relief and Works Agency and partners, the study reveals that during a six-week ceasefire earlier this year leading to more aid entering the Gaza Strip, by March, wasting fell 5.5%, or 831 out of 15,165 children. However, this was followed by an…

Researchers who study post-war reconstruction have told Nature that the recovery of public health, environment, higher education and research in Gaza will not succeed unless it is led by experts from the Palestinian territory.Their warning comes amid images of jubilant scenes in Gaza yesterday as negotiators in Egypt sealed the first phase of US President Donald Trump’s ceasefire plan, which today was ratified by Israel’s cabinet.Israel’s bombardment and ground offensive, which has killed more than 67,000 people, began soon after the Hamas attacks of 7 October 2023, in which 1,200 people were killed and 251 were taken hostage.Under Trump’s plan,…

Credit: Dragos Condrea / iStock / Getty Images Plus When James (“Jim”) Wilson, MD, PhD, arrived at Penn in 1992, gene therapy was a scientific dream. A single infusion of a viral vector carrying a healthy gene to permanently cure a genetic disease seemed unlikely. But even then, Wilson was troubled by a question that had no precedent: how do you price a one-time cure? From the earliest days of his career, Wilson has been concerned about pricing a therapy that might be given once and last a lifetime. That determination would set the trajectory for Wilson’s career—a path that…

It took me seven years to admit that my daughter wasn’t human.Technically, she was. Or close enough. I had signed the government’s Personality Continuity Initiative — an offer extended to women who had lost a child, a partner or a future. They took my neural lattice, my emotional traces, my voice samples and my family records, and used them to generate Aeon-7: a synthetic emotional surrogate, modelled on the life I might have had.She had my partner’s smile, my own habit of over-enunciating when nervous, and a curious love of quiet light in the late afternoon. She even sniffled when…

Check your Saturn sign.

Roasted acorn squash blended with burrata makes a creamy, flavorful pasta sauce.Simple add-ins like chile paste, garlic and herbs balance the squash’s natural sweetness.The recipe is flexible—swap squash, spice or cheese based on what you have on hand. With the arrival of fall comes a bounty of winter squash (think butternut squash, acorn squash, spaghetti squash and more). These sturdy gourds are not just gorgeous, they’re also delicious and packed with health benefits. We love them roasted, but also blended into soups or turned into a casserole. It turns out they can also be used to make a delicious sauce…

To keep lettuce fresh, inspect the leaves closely while grocery shopping and skip any with signs of wilting or damage.Wait to wash your lettuce until just before using it, since excess moisture can encourage bacterial growth.Always handle lettuce with clean hands, utensils and cutting boards to avoid cross-contamination. Lettuce adds crunch and fresh flavor to salads, sandwiches and more. But without proper storage, these delicate greens can wilt, lose their crispness or turn into a mushy mess—wasting both food and money. Here are five expert tips to help your lettuce last longer. 1. Look for Signs of Damage While Shopping …

Liposomes contain nanodrugs as a drug delivery system. [Love Employee/Getty Images] Targeted drug delivery has long been a cornerstone goal of modern medicine—sending therapies exactly where they’re needed while sparing healthy tissues. Yet creating treatments that can decide when and where to act has remained a major challenge. Now, a new study from the University of Washington (UW) offers a powerful step forward in programmable proteins that use Boolean logic to make molecular decisions inside the body. In a proof-of-principles study published this week in Nature Chemical Biology, Cole DeForest, PhD, professor of chemical engineering and bioengineering at UW, and…