Author: admin

Company’s osteoporosis program completes enrollment in Phase 2 trial focused on treating the disease in postmenopausal women. US biotech Angitia Biopharmaceuticals has secured $130 million in a Series D financing to fuel the development of new medicines for musculoskeletal diseases. The money will be used to advance several clinical-stage programs, with its Phase 2 osteoporosis candidate most notable from a longevity perspective.   Los Angeles-based Angitia is focused on developing biologic therapies designed to strengthen bone and address conditions where it claims current treatments fall short. The company currently has three biologic candidates in clinical development, spanning osteoporosis, osteogenesis imperfecta,…

Once-a-month shot delivers meaningful weight loss, but Wall Street remains uneasy about competition, tolerability and timing. Pfizer’s obesity moment finally arrives… just not the way markets hoped. For the multinational pharma-biotech, the latest data on its experimental obesity drug PF’3944 was supposed to be a turning point. After years of stalled internal programs and a costly $10 billion acquisition of biotech Metsera, the company finally had something tangible to show: people on its drug lost substantially more weight than those on placebo, even after switching from weekly injections to just one shot a month [1]. Yet as the science moved…

Have you ever wondered why some people stay lean without effort while others struggle despite strict diets?  Recent health news has been buzzing about the fat switch discovery, a term describing a breakthrough in how we understand human metabolism.  For decades, we believed weight management was a simple math problem of calories in versus calories out. However, this fat switch viral health discovery suggests that our biology is far more complex than a calculator. Researchers are calling this a new weight loss breakthrough because it focuses on a biological “toggle” in our cells.  This switch determines if your body is…

Tuna salad is the ultimate versatile meal—a high-protein staple for sandwiches, a refreshing topper for garden greens, or a quick snack enjoyed straight from a container. However, because it combines delicate seafood with creamy binders like mayonnaise, it is one of the most frequently questioned items in the kitchen when it comes to shelf life. If you have ever opened your refrigerator and hesitated, asking yourself, how long is tuna salad good for?, you are engaging in a vital piece of food safety intuition. The direct answer, backed by the USDA and FDA, is that tuna salad is generally safe…

Credit: Mixetto/Getty Images The Coalition for Epidemic Preparedness Innovations (CEPI) and CDMO Samsung Biologics formed a partnership to strengthen vaccine manufacturing preparedness for future epidemic and pandemic threats. The collaboration will see Samsung Biologics join CEPI’s Vaccine Manufacturing Facility Network (VMFN) with the aim of accelerating the availability of protein-based vaccines and advancing equitable access to those vaccines during future outbreaks in Low- and Middle-Income Countries (LMICs). Supported by an initial budget of up to $20 million, CEPI will work with Samsung to establish a scalable, rapid manufacturing process for recombinant-protein vaccines. Under the agreement, Samsung Biologics will also conduct…

Credit: Thitima Uthaiburom / iStock / Getty Images Plus A research team co-led by scientists at the Netherlands Cancer Institute (NKI) and Oncode Institute has developed a deep learning model, PARM (promoter activity regulatory model) that offers up new insight into the regulation of human promoters by transcription factors, and so how genes know when to switch on or off. The researchers say scientists can now start to use the tool for reading these genetic instructions, creating leads for new cancer diagnostics, patient stratification, and future therapies. They also suggest that their findings indicate that gene regulation is far more…

Credit: Uno et al., 2026 Researchers at Nagoya University in Japan have discovered why ovarian cancer cells can sometimes metastasize so fast without traveling through the bloodstream. Published today in Science Advances, their findings show that these cancer cells can recruit healthy mesothelial cells lining the abdominal cavity to form hybrid spheres that are resistant to chemotherapy and spread to other tissues faster. Kaname Uno, PhD, postdoctoral researcher at Nagoya University’s Graduate School of Medicine and lead author of the study, explained that instead of invading other tissues themselves, ovarian cancer cells “manipulate mesothelial cells to do the tissue invasion…

Credit: koto_feja /E+/ Getty Images Neutrophils are known as first responders to threatening infections and feature prominently in the microenvironment of tumors to resist cancer progression. Though neutrophils have been linked to the growth of multiple cancers, such as lung and breast, these cells can assume multiple functional states.  In a new study published in Cancer Cell titled, “CCL3 is produced by aged neutrophils across cancers and promotes tumor growth,” researchers from Ludwig Institute for Cancer Research in Lausanne have discovered a gene expression program executed by tumor-associated neutrophils (TANs) and a corresponding biomarker that uniformly support cancer cell survival and tumor progression across human and murine tumors.  Results…

New data link low-dose mTOR inhibition to DNA protection in aging immune cells, reframing how rapamycin’s healthspan effects might work. Aging is rarely a matter of the dramatic – or, at least, it does not begin that way. Rather, it is a quiet accumulation of subtle deficits, manifesting as systems that simply cope a little less robustly than they once did. The immune system is perhaps the most visible case in point; as the decades pass, immune responses begin to soften, vaccines lose their potency and that persistent, low-grade hum of inflammation becomes increasingly difficult to silence. Yet, beneath these…

Credit: haydenbird / Getty Images For decades, brain MRI has been one of medicine’s most powerful diagnostic tools—and one of its most resource-intensive. Demand continues to rise, while neuroradiology services struggle to keep pace, leading to delayed diagnoses, workflow bottlenecks, and widening disparities in access to care. A new study from the University of Michigan suggests artificial intelligence may help close that gap. Reporting in Nature Biomedical Engineering, researchers describe Prima, an AI model capable of reading a complete brain MRI and generating clinically meaningful diagnoses in seconds. Trained on health system-scale data rather than narrow, hand-curated datasets, Prima represents a…