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The Sound Life study cohortHealthy 25- to 35-year-old and 55- to 65-year-old adult donors were prospectively recruited from the greater Seattle, Washington, USA, area as part of the Sound Life Project, a protocol (IRB19-045) approved by the Institutional Review Board (IRB) of the Benaroya Research Institute. All adult participants provided informed consent before participation. Donors were excluded from enrolment if they had a history of chronic disease, autoimmune disease, severe allergy or chronic infection. All blood samples were collected, processed to PBMCs through a Ficoll-based approach and frozen within 4 h of blood draw. Plasma samples were processed, aliquoted and frozen within 4 h of blood…
What are the four pillars of gut health? A summaryConsumer interest in gut health rose sharply with searches up 35 percentGlobal gut health market valued at $14.4bn with 8.4 percent CAGRFour pillars of gut health are shaping the future of food and beverage innovationFood and beverage brands innovating with probiotics, adaptogens and moreProducts now target gut-brain axis, emotional resilience and sleep supportGut health is one of the hottest topics in food and beverage. If you haven’t yet heard of the microbiome, or are thinking of ways to add probiotics to your diet, then we can only assume you’ve been living…
An international research team led by scientists at the University of Toronto, and at the University of Pittsburgh School of Medicine, has created what it says is a first-of-its-kind resource to identify individuals with a genetic risk for elevated low-density lipoprotein (LDL), or ‘bad’ cholesterol, a major contributor to heart disease. The team classified nearly 17,000 missense coding variants of the LDL receptor (LDLR) gene along with the corresponding changes in LDL receptor protein structure and uptake, creating maps relating sequence to function, and offering up functional insights and evidence for clinical utility. They suggest the resource could help clinicians…
Some women appear to sail through menopause with ease, transforming into nonfertile yet still sexy and sophisticated women of a certain age without breaking a sweat. For the vast majority, however, the experience is rockier: An estimated 80% have at least one menopausal symptom, which can range from occasionally waking up drenched in sweat to daily hot flashes that surprise you during important client meetings and dinner with your fiancé. And did we mention the brain fog, loss of libido, vaginal dryness, insomnia and moodiness?If you’re unlucky enough to have some—or several—of these problems, you can be fairly sure that…
Sertraline may start working on key depression symptoms such as suicidal thoughts and feelings of sadness within two weeks, much earlier than previously thought, new research shows.Published in Nature Mental Health,1 the study reanalysed data from 571 patients included in the Panda trial, a randomised controlled trial comparing the selective serotonin reuptake inhibitor (SSRI) sertraline with a placebo.The research team reported that the SSRI had “beneficial effects on core depression and anxiety symptoms as early as after two weeks of treatment” but that these may be masked by side effects of the drug and other symptoms of depression early on.The researchers…
Credit: Nikita John Creagh / Getty Images Results from a Phase III clinical trial have shown that patients who received a stem cell therapy within a week of a heart attack had a significantly lower risk of developing heart failure within the next three years compared to patients who received the standard care. Based on these findings, published today in the BMJ journal, the researchers propose stem cell therapy as an add-on treatment to prevent future heart failure and related hospital stays in patients at risk. While deaths due to heart attacks have dropped by nearly 90% over the past…
Amid growing demand for non-hormonal solutions in menopause care, AB-Biotics and Kaneka Probiotics spotlight a three-strain, science-backed probiotic with a targeted action on the estrobolome, a key regulator of estrogen metabolism. Ahead of the companies’ webinar, “Probiotic Innovation in Menopause: Expert Perspectives and Clinical Evidence,” Nutrition Insight meets with one of the speakers to learn about the estrobolome and the latest clinical evidence for their innovative probiotic formulation, Gyntima/KABP Menopause. “This is the first — and to our knowledge, the only — probiotic formula clinically proven to modulate estrogen levels in menopausal women, helping to slow down the natural decline that…
Ina Garten says she’s never been a fan of classic pumpkin pie.She makes pumpkin spice cupcakes with maple frosting for Thanksgiving instead.Garten also skips making dinner rolls, opting for bakery-bought or none at all. It’s always fun to hear someone’s food hot take, from Selena Gomez’s love of bread and butter pickles to Chelsea Handler’s disdain for pineapple on pizza. Now, just in time for the holidays, Ina Garten has dropped her own hot take—Thanksgiving edition. In her Substack email newsletter, the Barefoot Contessa shares that there’s a traditional Turkey Day dessert she’s just not that into. “The truth is,”…
In 2022, neurosurgery researcher René Aquarius and Kim Wever, his colleague at Radboud University Medical Center and an expert in systematic reviews of animal studies, were about to embark on a literature review project when they noticed several odd things that made them stop in their tracks, then change the course of their study entirely.René Aquarius is a neurosurgery researcher at Radboud University Medical Center. He seeks better treatment options for patients with brain conditions such as hemorrhagic stroke.René AquariusAquarius had planned to review animal models of subarachnoid hemorrhage, a type of stroke, in hopes of finding better treatments for…
NEWS AND VIEWS 29 October 2025 As the giants of the animal kingdom dwindle in numbers, a new way to assess ecosystem function sheds light on animals’ changing ecological contributions.