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Did someone say cuffing season?

Credit: Pixelgen Technologies Background Chimeric antigen receptor (CAR) T cell-based therapy has greatly improved cancer treatment, especially for hematologic cancers.1 By providing T cells with synthetic receptors that target tumor antigens, like CD19 in B cell malignancies, CAR T cells are enabled to identify and destroy cancer cells with high precision and potency.2 Despite this progress, hurdles such as antigen loss, T-cell dysfunction, and limited success in solid tumors underscore the need for deeper mechanistic insights into CAR T cell biology. Recent research indicates that the spatial architecture of membrane proteins is crucial for regulating T-cell signaling and activation.3-5 In…

Starting your day on a healthy note is easy with these satisfying Mediterranean diet breakfast recipes. The Mediterranean diet is considered one of the healthiest eating patterns around, and prioritizes staple ingredients like whole produce, legumes, lean protein and grains. It’s also been known to provide a variety of health benefits, including supporting heart health and reducing inflammation.  Each of these Mediterranean diet dishes also contains at least 6 grams of fiber and includes probiotic and/or prebiotic foods like strained (Greek-style) yogurt , kefir, beans and oats, to meet our gut healthy parameters. Try options like our Black Bean &…

A smoothie a day is arguably one of the easiest ways to pack in loads of nutrients—many of which you can customize tailored to your health goals. Want more protein? Toss some powder in your smoothie. Looking for immune support? Load up your blend with citrus. 

Once considered passive messengers of genetic information, RNA molecules are now understood to play an active and dynamic role in gene regulation, modulated by a rich layer of chemical modifications collectively known as the epitranscriptome. Among these, N6-methyladenosine (m6A) is the most abundant mRNA internal modification, present on thousands of transcripts and implicated in diseases such as cancer and neurological disorders.1,2 These modifications add regulatory depth to gene expression by influencing mRNA stability, translation, trafficking, and splicing. Critically, their biological impact depends not only on where they occur, such as at splice junctions or near stop codons, but also on…

The ideal scrambled eggs have a soft, velvety texture with medium-sized curds.Chefs like using fresh, farm-sourced, cage-free eggs for better flavor and nutrition.Mix yolks and whites before cooking, use low heat, stir a lot and use the correct size pan. Scrambled eggs are one of those seemingly simple, underrated dishes that can immediately rustle up warm memories. For most, it’s one of the first things we learn to cook. I remember “helping” Mom with breakfast before I was tall enough to reach the stove, learning how to use a fork, then chopsticks, to turn eggs into a thick yellow curtain…

If you had the flu, you probably wouldn’t hesitate to call in sick to work or school to recover. And if you’re feeling stressed, overwhelmed, or exhausted, a mental health day may be just what the doctor ordered.”Self-care practices like proactively taking mental health days can be extremely effective tools to reduce the risk of burnout, chronic stress, and depression,” says Iman Hypolite, MD, an Atlanta-based psychiatrist who offers teletherapy in several states. “Self-care isn’t a luxury; it’s foundational.”[1]Mental health days are breaks from sources of stress or frustration that allow you to focus on nourishing your emotional well-being.Ideally, you’d be…

Strained (Greek-style) yogurt with berries is a top late-night snack recommended by dietitians.It’s rich in protein, fiber and nutrients that keep you full, steady your blood sugar and promote better sleep.Other ways to manage blood sugar include exercise, stress management and eating balanced meals. You’ve already eaten dinner, but your stomach is lightly grumbling before bedtime. Choosing the right nighttime snack can mean the difference between restless sleep or waking up refreshed, since going to bed too hungry—or too full—can disrupt sleep and impact blood sugar balance. “Late-night snacking often gets a bad reputation because it’s linked to mindless munching…

Just this week, Starbucks launched a protein foam add-on option and a line of lattes with protein-boosted milk. The offering is part of the coffee giant’s strategy to drive innovation and modernize its menu, a spokesperson from Starbucks said, adding a reference to a blog post that stated, “Our new protein beverages tap into the growing consumer demand for protein in an innovative, premium and delicious way.”“Our new protein beverages tap into the growing consumer demand for protein in an innovative, premium and delicious way.” – Starbucks (Starbucks / Danielle Masterson)Market research firm SPINS has been tracking this trend for…

Non-ionic surfactants such as polysorbates and poloxamers play a crucial role in biopharmaceutical formulations, improving protein stability and reducing aggregation. Polysorbates, such as Polysorbate 80 (PS80 or Tween-80), are among the most widely used surfactants in the pharmaceutical industry and are present in most commercial monoclonal antibody formulations.1 Regulatory agencies, including the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA), expect excipients such as surfactants to be appropriately selected, justified, and characterized, with their stability and potential degradation monitored throughout the product lifecycle. This expectation is reflected in ICH Q8(R2), various FDA guidance, and regulatory assessments…