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In a new study published in Nature Communications titled, “COOKIE-Pro: Covalent Inhibitor Binding Kinetics 2 Profiling on the Proteome Scale,” researchers at Baylor College of Medicine have developed a new data analysis method that provides a comprehensive, unbiased view of how covalent inhibitors interact with proteins throughout the cell. The technique aims to accelerate the design of more effective and safer therapeutics by precisely measuring both the binding strength and reaction speed of these drugs against thousands of potential targets simultaneously.  “Covalent inhibitors, which include well-known drugs like aspirin and the cancer therapeutic ibrutinib, are highly effective because they form…

Investments in neurodegeneration-focused startups set to continue as Sanofi Ventures gets significant cash infusion. Pharma giant Sanofi has revealed it is providing an additional $625 million to Sanofi Ventures, its corporate venture capital arm, with the funds earmarked for investments in early stage biotech and digital health. The multiyear capital infusion raises the evergreen fund’s assets under management to more than $1.4 billion, extending a decade-long strategy of identifying and nurturing early-stage companies in areas aligned with the French drugmaker’s long-term priorities. The additional capital for its investment arm comes as the biotech sector faces constrained access to early funding,…

Y Tony Yang, endowed professor and associate deanGeorge Washington University, Washington, DC, USAytyang{at}gwu.eduKirkland and Greer’s article about Robert F Kennedy Jr and others in the antivaccine movement offers a timely and urgent critique of current US vaccine policy leadership and its global ripple effects.1 The article rightly highlights the dangers of politicising vaccine science and the erosion of expert driven policy, but I think the discussion would benefit from a broader, more nuanced perspective on …

A new study finds that it is not too late for older adults to improve their health and well-being through lifestyle interventions.Researchers at the University of Toronto, Canada, found that almost 25% of adults over 60 with poor well-being were able to improve within three years. The publication in PLOS One underlines the importance of lifestyle and psychosocial factors in healthy aging.Those with poor well-being reported pain, health issues, low mood, or isolation. People with strong psychological wellness at the start of the study were noted to be five times more likely to achieve ideal health.The study notes that healthy…

To gain a complete picture of cell development, scientists recently filmed cells in the live skin tissue of frog embryos. They quantified changes in cell shape and movement and analyzed how these changes defined cell fate. Image credit:Raghavan ThiagarajanWhat do cells want to be when they grow up, and how do they get there? Intrigued by these questions, many developmental biologists try to follow the journeys of cells from when they can virtually become any kind of cell to when they have reached their final fate. Scientists can take snapshots of this journey at specific timepoints, but what happens between these…

RESEARCH HIGHLIGHT 30 September 2025 Satellites help scientists to document a correlation between dust travelling from Africa and hailstones falling in the Alps.

Spinach is a great source of folate, a crucial nutrient that’s especially important for those who are pregnant or breastfeeding. However, if you don’t want to dig into a green salad every day, these delicious recipes are the folate-rich lunches or dinners that you’ve been looking for. With 116 milligrams or more of folate (about 30% of your daily needs) per serving, these meals have more of the nutrient than a standard 2-cup serving of spinach. Try out our Roasted Potato Tzatziki Bowls for a hearty dinner, or our 5-Ingredient Avocado & Chickpea Salad for a lunch that’s easy to…

Credit: Keith Chambers / Getty Images / Science Photo Library Marc Hedrick, MD, MBA, a physician-turned-biotech executive, has been tracking survival curves for cancer for decades. While survival rates for many cancers have improved, sometimes dramatically, Hedrick noticed patients with central nervous system (CNS) cancers have been left behind. “Over the last forty years, survival rates for cancers outside the CNS have increased by 300%,” Hedrick told Inside Precision Medicine. “For CNS cancers, the survival curve is basically flat. Despite all the advances in imaging, despite MRI transforming how we diagnose and locate tumors, the outcomes have hardly changed.” For…

Black Sheep Egg Company recalls brown eggs in two states for possible Salmonella contamination.The 12- and 18-count cartons affected have best-by dates from August through October 2025.No illnesses yet, but FDA warns recall could expand; return or dispose of recalled eggs. A recall was just announced on brown eggs sold in two states, according to the U.S. Food and Drug Administration (FDA). This is due to a potential Salmonella contamination.  The recall currently impacts 12-count and 18-count cartons of Black Sheep Egg Company’s Free Range Large Grade A Brown Eggs. The recalled cartons carry best-by dates of August 22 through…

Agency responds to petition by Natural Products Association and Alliance for Natural Health, allowing NMN as a dietary supplement. Once feted as a promising addition to the NAD+ supplement landscape, nicotinamide mononucleotide (NMN) found itself at the center of regulatory turbulence when the US Food and Drug Administration (FDA) concluded in 2022 that the compound was excluded from the definition of a dietary supplement. That conclusion rested on the so-called drug exclusion clause; NMN was already the subject of an Investigational New Drug application, and FDA argued that marketing it as a supplement was therefore unlawful. The impact was immediate…