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View eBook The oligonucleotide therapeutics market is growing, and the pipeline is diverse. With more than 1200 oligo therapeutics in development and over 20 commercialized oligonucleotide drugs on the market to date, the potential for these highly specific sequences is being realized and is set to continue. Building on 40 years of experience, we at Cytiva understand that achieving high-quality and cost-effective oligonucleotides for your patients depends on successful drug development, optimization to manufacture, and a smooth scale-up. Having expertise and experience at hand is key when optimizing your synthesis process and will provide the right support for your full…

Synthetic biology has long relied on cell-based cloning to address the shortcomings of synthetic DNA. While an effective approach to isolate and amplify sequence-perfect DNA molecules from molecules containing synthesis errors, it has distinct limitations when it comes to producing complex structures such as lengthy DNA repeats or hairpins. Additionally, traditional cloning is a slow, multi-step workflow that carries the risk of contamination from bacterial gDNA and endotoxins.Cell-free synthesis addresses these issues by completely eliminating cells from the workflow to manufacture highly repetitive or complex sequences rapidly from a manufacturing footprint roughly 10-fold smaller than cell-based processes.In this GEN webinar,…

Credit: Ivan-balvan/Getty Images Inherited retinal disease mutations are less likely to actually cause disease than previously expected, according to research led by Harvard University. The study, published in the American Journal of Human Genetics, looked at people in both the All of Us cohort in the U.S. and the UK Biobank and showed that less than 30% of people carrying known inherited retinal degeneration mutations actually had signs of disease despite correcting for factors such as age and misclassification. The researchers suggest that background genetic factors, epigenetics, or environmental exposures likely explain whether and how severely carriers are affected. “Although…

An end-of-year experiment exploring how large language models perceive leadership in AI-driven longevity. As the year draws to a close, it feels increasingly difficult to ignore how much large language models now shape what we see, read and remember. They summarize research, surface experts, rank relevance and, increasingly, act as quiet arbiters of authority across fields that remain fluid, contested and fast-moving. Longevity science – and particularly its intersection with artificial intelligence – sits squarely in that category. So, rather than offering a traditional editorial ranking, Longevity.Technology set up a small experiment. We asked multiple large language models the same…

Working at the intersection of optics and plasma physics, this postdoc explores laser-driven nanostructuringImage credit:Samir Das, ©iStock.com, Pavel MuravevQ | Write a brief introduction to yourself including the lab you work in and your research background. I am Md Abu Taher. I am currently an Institute Postdoctoral Fellow at the Center for Laser and Photonics in the Indian Institute of Technology Kanpur. My research spans ultrafast laser–matter interaction, nonlinear optics, and plasma physics, with expertise in laser-based nanostructuring, high-density plasma generation, and beam propagation modeling for advanced materials processing and scientific applications.Q | How did you first get interested in…

Scientists studied various aspects of cancer, including leveraging lessons from animals that don’t get the disease to developing non-invasive diagnostic tests for colorectal cancer.Image credit:© iStock.com, gevendeCancer research this year reshaped how scientists understood, detected, and treated the disease. Researchers figured out how viral infections could reawaken dormant cancer cells, leveraged lessons from animals that don’t get cancer, and made new discoveries to better understand and detect colorectal cancer. Take a look at the top cancer stories of the year 2025.Influenza virus caused dormant cancer cells (green) in mouse lungs to reawaken and begin dividing, determined by expression of a…

“Stay private as long as you can continue to access capital,” venture capital investor Bruce Booth, DPhil, a partner with Atlas Venture, advised biopharma CEOs in October on his blog LifeSciVC. “One should only go public if you really can’t fund yourself as a private company through the important data inflection points. I’ve heard plenty of regrets from CEOs who got beaten up in the public markets, who went out too early, and I’ve shared those regrets as an underwater investor on several painful occasions.” But as 2025 fades into history, biopharma CEOs who have gone public appear to have…

Researchers at the Max Delbrück Center and the University of Oxford have found that a cellular housekeeping function called autophagy—by which cell components are broken down and recycled—plays a major role in ensuring that T stem cells undergo normal, asymmetric cell division (ACD). Studying a specific mouse model that allows researchers to sequentially tag mitochondria in mother and daughter cells, the team discovered that autophagy is involved in regulating the distribution of healthy and damaged mitochondria between daughter T cells, which then impacts T cell fate. The researchers, led by Mariana Borsa, PhD, professor at the University of Oxford and…

Picture a Saturday morning. The smell of batter hitting a hot griddle fills the kitchen, and a stack of golden, fluffy discs awaits a generous pour of maple syrup. It’s the quintessential comfort breakfast. But as we become more conscious of what fuels our bodies, a nagging question often interrupts the nostalgia: Are pancakes bad for you? It’s a valid concern. In an era where low-carb, keto, and whole-food diets reign supreme, a plate of white flour and sugar seems like a nutritional relic. Are we starting our day with a treat that belongs on a dessert menu, or is…

Quick Answer: A single ostrich egg contains approximately 170 to 235 grams of protein, which is roughly equivalent to the protein found in 24 chicken eggs. In terms of density, ostrich eggs provide about 13 grams of protein per 100g, making them nutritionally similar to chicken eggs but significantly larger in volume and total calories (~2,000 kcal per egg). Imagine standing in your kitchen, holding an egg that weighs as much as a small dumbbell. It requires two hands to hold; the shell is as thick as porcelain, and it holds the culinary potential of two dozen standard breakfast eggs. …