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Tumour progression and spread are influenced by a variety of factors. These include communication between cells, the presence of differing types of cellular lineage in a cancer (tumour heterogeneity) and variations in cellular states (a phenomenon called plasticity, which describes the adaptability of these cells). Plasticity is often coupled to a process called the epithelial–mesenchymal transition (EMT), which is associated with one type of cell (an epithelial cell) losing its usual characteristics and switching to resemble a different type of cell (a mesenchymal cell). All of the above contribute to a poor prognosis1,2. Writing in Nature, Li et al.3 present…
Doris Franklin (née Johnson) was born in 1931. She studied medicine at Liverpool University, graduating in July 1956 before going on to specialise in paediatrics.After training appointments at hospitals in Liverpool in 1957 she spent a year at Kingston Hospital, Ontario, Canada, doing postgraduate medical training. She …
A magnified image of a brain organoid with fluorescent labelling of various cell types.Credit: Thomas Hartung, Johns Hopkins UniversityAdvanced tools and techniques are giving researchers a detailed look at the body’s defence system. From spotting single cells in action to improving or replacing animal models, the methods described below are helping immunologists to push the boundaries of their work in 2025.THX mice: mouse on the outside, human on the insideSince the first mouse models with human cells and tissues were developed more than 40 years ago, they’ve become much better at mimicking the human immune system. But they’re still nowhere…
Some people experience itchy, red skin and anaphylaxis after exercising. Mast cells secrete histamines which likely cause such a reaction, but scientists still do not fully understand the underlying mechanisms.Image credit:© iStock.com, PeopleImagesImagine going for a run. The first mile feels great: energy rising, blood pumping. Until a rash creeps up, giving way to itchy, red welts, flushed skin, and hives. For people with such a condition—called exercise-induced urticaria—a jog can turn into a battle against their own immune system.First described in the 1970s, exercise-induced urticaria is a relatively rare condition likely due to a sudden increase in the body’s…
This salmon recipe makes an easy, flavorful weeknight dinner that’s ready in 25 minutes. Salmon is rich in omega-3 fatty acids, which help to lower inflammation. To get evenly cooked fish, choose salmon fillets that are about 1 inch thick. Our Baked Lemon-Pepper Salmon uses a genius cooking method to infuse maximum lemon flavor into your salmon. Skinless, omega-3-rich salmon fillets are nestled on top of lemon slices and baked with a seasoning blend of lemon-pepper, salt and garlic powder. The fish is roasted with heart-healthy olive oil and sprinkled with fresh, aromatic dill. Keep reading for our expert tips on…
How Endometrial Cancer Treatments Change Your BodyEndometrial cancer treatments can affect your body’s appearance and function. And both are closely related to our identity and how we see ourselves.[1] When cancer treatment changes your body’s appearance, function, or both, it can affect how you see yourself socially, in your relationships, sexually, and even at work, says Jeanelle Folbrecht, PhD, a clinical health psychologist and the psychology chief at City of Hope in California.Here are the most common changes that can affect body image in women who have undergone endometrial cancer treatment.Surgical EffectsSurgery is often part of endometrial cancer treatment. Depending…
Sleeping seven to nine hours a night can help lower blood pressure, balance hormones and support glucose control.A lack of sleep can lead to poor decision-making, increased hunger and altered heart function.Quitting smoking, staying active and transcendental meditation are other supportive heart health measures. Sleep is one of the most underrated habits for heart health, and yet, many Americans don’t get enough. The Centers for Disease Control and Prevention (CDC) estimates that nearly 37% of adults sleep less than seven hours per night, the minimum amount recommended for optimal health. While skimping on sleep may not seem like a big…
Bereaved families and survivors of a pro-suicide online forum are demanding that a public inquiry be held into government inaction over such websites and the harm they have caused.The Molly Rose Foundation published a report on 17 October highlighting what it described as “multiple missed opportunities” by government departments to take effective action against such forums.1The foundation was set up by family and friends of 14 year old Molly Russell after her death in 20172 to focus on suicide prevention, particularly in people under 25. It carried out a systematic review of 47 prevention of future death reports where deaths…
Nature, Published online: 22 October 2025; doi:10.1038/d41586-025-03130-4A stable ‘frequency comb’ of photons with discrete colours has been generated on a microscale chip by removing copper contaminants from the circuit.
This sector is growing faster than many other markets with a compound annual growth rate (CAGR) of 4% and countries like the UK and France showing steadily increasing demand.While Germany and Italy currently lead spending on memory and mood supplements (accounting for 26% and 18% of Western Europe, respectively), these figures are beginning to plateau.In contrast, the UK and France—which represent 14% and 13% of the market—are expanding at twice the rate of other Western European countries. Other fast-growing markets include Finland, Greece, Spain and Sweden.There is also an interesting evolution happening in the sector, according to Nick Stene, Euromonitor’s…