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For decades, gene-editing science has been limited to making small, precise edits to human DNA, akin to correcting typos in the genetic code. Arc Institute researchers are changing that paradigm with the development of a universal gene editing system that allows for cutting and pasting of entire genomic paragraphs, rearranging whole chapters, and even restructuring entire passages of the genomic manuscript. In a published paper in Science, the research team, headed by Patrick Hsu, PhD, an Arc Institute core investigator and University of California, Berkeley bioengineering faculty member, demonstrated how bridge recombinase technology can be applied to human cells. The…

This postdoc’s research bridges fundamental neuroscience and molecular biology to tackle chronic pain and neurodegeneration.Image credit:Isaac Killgore Photography, © iStock, koto_fejaQ | Write a brief introduction to yourself including the lab you work in and your research background. I am Kishore Kumar S Narasimhan, a neuroscientist passionate about understanding synaptic plasticity. As a postdoc in the Dravid Lab at Texas A&M University, I specialize in wet-lab techniques, advancing neural adaptability, and drug discovery projects. My academic journey from India to the US fuels my goal of translating scientific discoveries into impactful therapies for neuronal disorders.Q | How did you first get…

Kodiak Cakes just brought back its seasonal Pumpkin Power Cakes with 15 g of protein.Kodiak also launched a new microwaveable Pumpkin Chocolate Chip Muffin Cup.Both are flavorful ways to add more protein to your day and shake up your snack rotation. My one extremely picky child with sensory issues eats Kodiak Buttermilk Power Cakes every single day, either in waffle or pumpkin form, and my other picky child with even more sensory issues will eat Kodiak Power Cakes as pancakes when it suits him.  Actually, Kodiak Cakes are one of the only protein-rich foods that they both will eat. Chicken…

Millions of Americans are living with dementia, and those numbers are on the rise.Brown rice is rich in antioxidants and vitamins that may protect against dementia.It also provides fiber for steady blood sugar, which is critical for long-term brain health. Nearly 7 million Americans over age 65 are currently living with Alzheimer’s disease. And that number is expected to double over the next 35 years. While Alzheimer’s is, perhaps, the best-known form of dementia, there are other types of cognitive decline that can also impair your memory, decision-making skills and mental clarity.  Fortunately, healthy lifestyle choices can go a long…

United Space Structures Founder Bill Kemp on why governments must treat aging itself as the world’s greatest health challenge. Our healthcare systems are fighting an unwinnable war. Year after year, trillions are spent managing the symptoms of chronic disease – heart disease, cancer, diabetes, Alzheimer’s – yet the toll only grows. The cost to the US alone is over $4.8 trillion annually, 16.7% of GDP. That equates to more than $14,000 per citizen per year; for families it means savings drained and caregivers pulled from the workforce; for society it is a tax on productivity, innovation and well-being. The breakdown…

After a mouse received treatment to eliminate immune cells called microglia, it was injected with human progenitor cells that developed into human immune cells (green, pink and blue) in the animal’s brain.Credit: M. M.-D. Madler et al./NatureA fresh supply of the immune cells that keep the brain tidy might one day help to treat a host of conditions, from ultra-rare genetic disorders to more familiar scourges, such as Alzheimer’s disease.In the past few months, a spate of new studies have highlighted the potential of a technique called microglia replacement and explored ways to make it safer and more effective. “This…

Credit: FatCamera / E+/ Getty Images As COVID ramps up again and skepticism about vaccines is spread, many people are wondering if it is worth the risk to have the shot, particularly cancer patients.  One of the key challenges with vaccines in general is to prove they don’t just work in healthy people, but also in patients with serious diseases, who often need the protection most. Excluding these patients from trials improves safety and the validity of trial results, but leaves doctors and patients scratching their heads about whether or not to vaccinate. Now evidence is starting to be gleaned…

The American College of Sports Medicine (ACSM) recommends a combination of aerobic and strength training exercises for people with cancer.[9]Aerobic ExerciseThe benefits of aerobic exercise include weight management, fatigue reduction, and improvements in heart and lung health, says Winters-Stone.The recommended amount of aerobic exercise is 150 minutes a week (30 to 60 minutes a day, three days a week) of moderate-intensity exercises like walking, cycling, or water exercise, or 75 minutes a week of vigorous activity such as tennis or brisk walking.[9]Strength TrainingBenefits include building bone and muscle strength and fall prevention, says Winters-Stone.The recommended amount is two to three…

Julie Gould 00:09 Hello, and welcome to Working Scientist, a Nature Careers podcast. I’m Julie Gould. This is the third episode of the career planning series, supported by the International Science Council. Julie Gould 00:28 There are many different ways to approach career planning, and one of them is to create a plan and follow it. Decide where you’d like to be in two, five, ten years’ time, create some smart (SMART) goals, (which, we learned in episode two, are goals that are specific, measurable, action oriented, realistic and time bound), and then follow the steps to getting there. People…

New research in C. elegans from scientists at Howard Hughes Medical Institute (HHMI) helps explain how changes in the parents’ lysosomes that promote longevity are transferred to their offspring. Their findings are detailed in a new Science paper titled “Lysosomes signal through the epigenome to regulate longevity across generations.”  The work comes out of the laboratory of Meng Wang, PhD, a senior group leader at HHMI’s Janelia Research Campus. Previous research from the Wang lab showed that overexpressing a particular enzyme in C. elegans lysosomes extended its life by up to 60 percent. Surprisingly, offspring from these worms that did…