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Since January, scientists and universities in the US have faced interruptions in federal funding for research. Image credit:©iStock.com, PogoniciThe research community experienced a tumultuous 2025. The Trump administration froze funding and halted key functions at the National Institutes of Health (NIH) and other agencies. These decisions caused confusion and concern from researchers, clinicians, and patients alike. In response, these groups found unique ways to speak up and rally support for federally funded research. On January 22, the Trump administration restricted several operations across the NIH including grant reviews, communications with external sources, travel, and hiring. One researcher called the actions “devastating”…
Medications do not work the same way for everyone. Many people carry genetic mutations that affect their response to drugs, from painkillers to cancer treatments. Researchers investigate pharmacogenomics to learn how such variations in the genome affect a patient’s therapeutic response. In this article, we delve into the science of pharmacogenomics, how clinicians use it to inform personalized medicine, and some key examples of how pharmacogenomics is applied in clinical settings.What Is Pharmacogenomics?Pharmacogenomics, a portmanteau of pharmacology and genomics sometimes abbreviated as PGx, is the study of how an individual’s genetic variation affects their response to medication. The aim of…
In the world of sports nutrition, whey has long worn the crown. But as dietary needs shift and more people seek dairy-free, highly bioavailable alternatives, a new challenger—or rather, an old classic—is reclaiming the spotlight. Egg protein powder is surging in popularity, offering a complete amino acid profile, moderate digestion speed, and zero lactose. Whether you are an athlete looking to break a plateau, someone navigating a dairy sensitivity, or a home cook wanting to boost the protein content of your pancakes, egg protein is a versatile powerhouse. But is there a protein powder made from eggs that actually tastes…
Urolithin A may support healthier immune aging. New data shows promise, and surprisingly, some people can produce it from food. Longevity advice trends fast, but one molecule has been quietly building a fan base among researchers. Urolithin A, a compound produced in the gut when certain plant compounds are broken down, is now at the center of a new Nature study suggesting it could nudge the aging immune system in a healthier direction. The excitement is tempered with scientific caution and a reminder that lifestyle basics still carry the most weight. But the findings – plus the fact that some…
A standard medium-sized raw tomato (123g) contains approximately 22 calories. The calorie count varies slightly by size and variety: a single cherry tomato has about 3 calories, while a large beefsteak tomato contains around 33 calories. Because tomatoes are 95% water, they are considered a low-energy-density food perfect for weight loss. When you are tracking your daily intake or simply trying to make healthier food choices, one question often pops up in the produce aisle: how many calories in a tomato? The short answer is that tomatoes are incredibly low in calories. A standard medium-sized raw tomato (approximately 123g) contains…
Credit: Nemes Laszlo / Getty Images / Science Photo Library Aortic stenosis is one of the most common and deadly forms of heart valve disease, affecting millions worldwide. The condition develops gradually as the aortic valve narrows, eventually limiting blood flow from the heart. Yet despite its prevalence, medicine still lacks drugs that can prevent or slow its progression. Once the disease becomes severe, patients are left with only one option: valve replacement through surgery or catheter-based procedures. A new study from researchers at UC San Francisco and the Broad Institute of MIT and Harvard suggests that this reactive approach…
From insulin to GLP-1s, peptide therapies harness the body’s own signaling molecules to target aging, disease and healthspan with precision. Peptides may be tiny, but in biology they punch well above their weight. These short chains of amino acids act as the body’s internal messengers, quietly coordinating everything from metabolism and immune defense to tissue repair and brain signaling. In recent years, advances in biotechnology have brought peptides out of the lab and into clinics, positioning them as a versatile therapeutic tool at the intersection of precision medicine, longevity science, and preventive care. For a field increasingly focused on extending…
In the final episode of 2025, the GEN team came together to reflect on some of the stories over the last year that they each found impactful. Some of the stories were covered in GEN’s December issue, but our editors took the time to discuss some topics in a bit more depth during the podcast. The discussion began with an update on the progress of AI use in drug discovery. Cell and gene therapy was a big topic with the positive outcome for Baby KJ, while Sarepta dealt with a rollercoaster of a year with their DMD treatment, Elevidys. Research…
Credit: University of Exeter Researchers at the University of Exeter have discovered a potential new target against infections from Candida auris, a fungus responsible for deadly infections in at-risk populations. Thanks to the development of a new animal model to study host-pathogen interactions, the team found that C. auris upregulates the expression of genes involved in iron metabolism during infection. “Since it emerged, Candida auris has wreaked havoc where it takes hold in hospital intensive care units. It can be deadly for vulnerable patients, and health trusts have spent millions on the difficult job of eradication,” said Hugh Gifford, MD,…
Funding accelerates clinical rollout of glycan biomarkers for aging and inflammation, pushing them into mainstream preventive care. GlycanAge, a London-based biotech pioneering glycan-based biomarkers for biological aging and chronic inflammation, has raised $8.7 million to accelerate clinical development and expand access to glycan testing in hospitals and preventive healthcare systems worldwide. The funding round was led by Fifth Quarter Ventures, with participation from Guinness Ventures, BrightCap Ventures, South Central Ventures, Impetus Capital, Vesna Deep Tech VC and Lightfield Equity. Existing investors, including LaunchHub Ventures and Kadmos Capital, also joined the round on a pro rata basis. The raise marks a…