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Credit: Keith Chambers / Getty Images / Science Photo Library Marc Hedrick, MD, MBA, a physician-turned-biotech executive, has been tracking survival curves for cancer for decades. While survival rates for many cancers have improved, sometimes dramatically, Hedrick noticed patients with central nervous system (CNS) cancers have been left behind. “Over the last forty years, survival rates for cancers outside the CNS have increased by 300%,” Hedrick told Inside Precision Medicine. “For CNS cancers, the survival curve is basically flat. Despite all the advances in imaging, despite MRI transforming how we diagnose and locate tumors, the outcomes have hardly changed.” For…

Black Sheep Egg Company recalls brown eggs in two states for possible Salmonella contamination.The 12- and 18-count cartons affected have best-by dates from August through October 2025.No illnesses yet, but FDA warns recall could expand; return or dispose of recalled eggs. A recall was just announced on brown eggs sold in two states, according to the U.S. Food and Drug Administration (FDA). This is due to a potential Salmonella contamination.  The recall currently impacts 12-count and 18-count cartons of Black Sheep Egg Company’s Free Range Large Grade A Brown Eggs. The recalled cartons carry best-by dates of August 22 through…

Agency responds to petition by Natural Products Association and Alliance for Natural Health, allowing NMN as a dietary supplement. Once feted as a promising addition to the NAD+ supplement landscape, nicotinamide mononucleotide (NMN) found itself at the center of regulatory turbulence when the US Food and Drug Administration (FDA) concluded in 2022 that the compound was excluded from the definition of a dietary supplement. That conclusion rested on the so-called drug exclusion clause; NMN was already the subject of an Investigational New Drug application, and FDA argued that marketing it as a supplement was therefore unlawful. The impact was immediate…

Anne GullandThe BMJagulland{at}bmj.comGraham MacGregor had three weapons in his campaign armoury: persistence, bloody mindedness, and charm, as he explained on the BBC Radio 4 programme The Life Scientific in 2017.This three pronged strategy certainly paid off: MacGregor’s career long battle against salt (and later sugar) led to governments agreeing to limit levels in processed food and prevented thousands of people dying from strokes and heart disease.Mark Caulfield, professor of clinical pharmacology at Queen Mary University of London and a close colleague, described MacGregor as a visionary. “Not that many clinicians are policy changers—for most researchers the metric is that we…

Note: The U.S. Food and Drug Administration (FDA) doesn’t approve supplements for safety or effectiveness. Always talk with your healthcare professional about whether a supplement fits your health needs, and about possible drug interactions or safety concerns. You’ll want to be careful with vitamins, minerals, and other dietary supplements if you have metabolic dysfunction–associated steatohepatitis (MASH) . While some nutritional supplements can help address deficiencies that are common among people with MASH, others do more harm than good, says Margaret O’Brien, RD , of Banner Health in Phoenix, Arizona. Your lifestyle can strongly affect your liver health, and your MASH…

An mRNA vaccine suppressed neovascularization—a condition caused by age-related macular degeneration (AMD), a leading cause of vision loss for elderly people—in the retina of mouse models. The vaccine can be delivered intramuscularly and offers a more comfortable and easier-to-administer alternative for treating AMD and other neovascular eye diseases. This research is published in Vaccine in the paper, “mRNA vaccination mitigates pathological retinochoroidal neovascularization in animal models.” AMD is one of the leading causes of vision loss in people over 60 years; the condition affects nearly 200 million people worldwide. One form of the disease, known as wet AMD, is caused…

Like counting sheep at bedtime, Countable PCR empowers scientists to accurately count nucleic acid molecules one by one.Image credit:©ISTOCK, Sudowoodo DNA and RNA are central to laboratory and clinical research, where quantifying their abundance is key to applications such as gene expression analysis, cell and gene therapy development, and circulating tumor DNA detection. To obtain these measurements, researchers and clinicians use several methods, including quantitative PCR, digital PCR, and next-generation sequencing. However, these approaches provide only estimated values based on ambiguous amplification curves, complicated statistical approximations, or complex computational reconstructions. This uncertainty reduces scientists’ confidence in the resulting measurements.To improve…

Be the first to rate & review! Sweet beets get a flavor boost from roasted garlic in this simple side dish. As the beets roast in the oven, a whole head of garlic roasts alongside them. Mashed with a touch of melted butter and fresh herbs, the garlic coats each bite with savory flavor. You can make this recipe with red beets, golden beets or a colorful mix for a vibrant presentation. Easy enough for weeknight cooking but special enough for a holiday spread, this recipe is a delicious way to showcase the earthy root vegetable. Published on September 30,…

Credit: Mohammed Haneefa Nizamudeen / iStock / Getty Images Plus A new international study led by Mayo Clinic researchers has identified a genetic factor that may explain why some patients with colorectal cancer that has spread to the liver experience more severe liver damage after chemotherapy. In their study, published in The Lancet eBioMedicine, the team showed the a single nucleotide polymorphism (SNP) in the PNPLA3 gene is associated with a heightened risk of chemotherapy-associated liver injury (CALI) in patients receiving neoadjuvant chemotherapy for colorectal cancer liver metastases (CRLM). “This is the first study to clearly show that a genetic…

The study identified 60 metabolites and the metabolic patterns associated with vitamin D deficiency (VDD) in early pregnancy, providing new proof of vitamin D’s beneficial effect on pregnant women’s lipid levels and offering insights into the underlying mechanisms. Published in Nutrients, the study identified metabolite changes unreported in earlier investigations. Specifically, VDD was linked with upregulated benzenoids, organic acids and organic oxygen compounds, suggesting it may disturb aromatic compound metabolism and broader energy-related pathways.“This study provides new metabolomic evidence for the linkage between vitamin D and maternal lipid levels during pregnancy, along with clues about the mechanisms,” the report stated.Vitamin…