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View eBook   Biomanufacturing is entering a new era, driven by urgent demands for lower drug costs, faster development timelines, and more sustainable operations. The traditional batch-based models that once defined monoclonal antibody (mAb) production are no longer sufficient to meet the growing complexity of today’s therapeutic pipeline or the global need for affordable access. Process intensification (PI) is emerging as a transformative response. Rather than viewing PI as a single technology or step, industry leaders are increasingly embracing it as a holistic, stepwise strategy to reimagine the entire biomanufacturing process, from upstream scale-up to downstream purification and beyond. PI…

This isn’t your regular scale.

When you sleep, your tongue and surrounding throat muscles relax, which helps air flow to your lungs.If you have OSA, though, your airway is narrow. So when your tongue and surrounding throat tissues relax, sleep apnea can temporarily block the flow of air and cause brief pauses in breathing.[1]How does sleep position come into play? Lying on your back, for example, can cause your tongue and throat tissues to collapse further, making it even harder for air to flow to your lungs, says Stephen Carstensen, DDS, a dental sleep specialist who treats sleep-related breathing disorders in Bellevue, Washington. This is…

A porous sponge system streamlines T cell activation and transduction into a single step, reducing workflow complexity while maintaining efficiency without chemical enhancers or other transduction-enhancing methods.Image credit:©iStock, luismmolinaViruses are effective tools for delivering genetic material into cells, and scientists have taken advantage of viral transduction in numerous ways, such as constructing chimeric antigen receptor (CAR) T cells for cancer therapy. However, traditional methods of T cell transduction are often error prone, time consuming, and require large amounts of material.In May 2025, Takara Bio USA rolled out the Lenti‑X T‑Cell Transduction Sponge to address these cellular engineering pain points. The company…

A crime laboratory officer removes material from the house of the prime suspect in the Gilgo Beach killings.Credit: Jeenah Moon/AP Photo/AlamyA judge in New York rejected a request on 23 September to disqualify the use of cutting-edge DNA sequencing as evidence in a case against an alleged serial killer. The ruling paves the way for a type of DNA analysis known as whole-genome sequencing — used to decipher ancient DNA in fossilized remains, for example — to be admitted as evidence in US criminal trials.“This is a big step forward for the use of DNA evidence, because it will allow…

Credit: Andrew Brookes / Connect Images When Alnylam Pharmaceuticals announced it would join the Alliance for Genomic Discovery (AGD), formed by Illumina and Nashville Biosciences, as the ninth biopharma member, the move signaled more than a new partnership. It marked another step toward reshaping precision medicine with large-scale, ancestrally diverse genomic data and detailed clinical records—resources long dominated by European cohorts. “Genetic evidence is one of the most powerful tools we have to improve drug discovery,” Will J. Ferguson, vice president of pharmaceutical and biotech collaborations at Illumina, told Inside Precision Medicine. “AGD was designed to bring together all the…

YouthBio receives positive FDA feedback on therapy designed to restore youthful gene expression patterns and address drivers of Alzheimer’s. Epigenetic rejuvenation startup YouthBio Therapeutics has received encouraging feedback from the US FDA on its investigational Alzheimer’s therapy YB002 as it seeks to bring partial cellular reprogramming into the clinic. The company today revealed that, following an INTERACT meeting with the agency, regulators agreed that existing preclinical data support the bioactivity of YB002 and the company’s proposed plans for a first-in-human trial. YouthBio now plans to prioritize chemistry, manufacturing and controls (CMC) activities along with a pilot toxicology study ahead of…

Published in the journal Frontiers in Nutrition, the report revealed approximately 60% of the studies reviewed focused exclusively on male athletes, and only 10% on female athletes, “highlighting a notable gap in our understanding of supplement effects on female athletes at the elite level.” Reviewed data revealed supplement effectiveness varies significantly based on multiple factors including the type of supplement, dosing protocols, timing of administration and individual athlete characteristics. “The findings underscore the critical importance of individualized supplementation strategies, moving beyond generic protocols to consider athlete-specific factors such as training status, competition schedule and physiological response patterns,” the report noted.…

Toxic family systems become your own personal kryptonite.

Get a healthy serving of vegetables with these satisfying casseroles. They’re packed with quintessential fall vegetables like cauliflower, butternut squash and sweet potato for a flavorful and seasonal main or side. Keep your baking dishes within arm’s reach because you’ll want to make recipes like our Spiced Butternut Squash & Apple Casserole or our Creamy Chicken, Cabbage & Mushroom Casserole on repeat all season long. Love any of these recipes? Join MyRecipes to save, search and organize your EatingWell recipes all in one place. It’s free! Spiced Butternut Squash & Apple Casserole Photographer: Morgan Hunt Glaze, Prop Stylist: Lydia Pursell,…