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RESEARCH BRIEFINGS 24 September 2025 Earth’s most diverse biological entities are the viruses that infect bacteria, called bacteriophages (phages). They are rich resources for discovering proteins and tools for biotechnology, but many phage–bacteria systems resist genetic manipulation. Silencing phage genes in a non-genetic way with short synthetic nucleic acids offers a solution.

Credit: PIXOLOGICSTUDIO /SCIENCE PHOTO LIBRARY/ Getty Images A particular immune system signature present in the antibodies of some people could leave them at increased risk of dengue fever after vaccination, researchers reported. The findings, in Science Translational Medicine, demonstrated how both the quality and quantity of antibodies generated by vaccines can affect their effectiveness. The study found that people with a particular modification in their immunoglobulin (IgG) antibodies were susceptible to reinfection. The research highlights immune factors that could be targeted in future vaccine strategies for both dengue and other diseases. “Overall, these findings emphasize the importance of considering both…

The positive improvements reported in adults were primarily in non-verbal memory and sleep disturbance, with no differences in verbal memory or executive function compared to placebo.“This is the first controlled study demonstrating the cognitive-enhancing and sleep-promoting effects of stand-alone supplementation with tocotrienols,” wrote researchers at Clinical Research Australia, Murdoch University and BGG Americas, which funded the study.Dr. Adrian Lopresti, lead authors and managing director of Clinical Research Australia, told NutraIngredients that there is already some research in the literature to support an association between eating vitamin E-rich foods and having higher blood concentrations of vitamin E with better cognitive health,…

Robertsonian chromosomes (ROB) are a type of structurally variant chromosome that is created when two chromosomes fuse together to form an unusual bond. Found commonly in nature, these chromosomes are present in about 1 in 800 humans, and while carriers may be asymptomatic, ROBs can underlie infertility, and contribute to trisomy. Scientists at the Stowers Institute for Medical Research, led by postdoctoral research associate Leonardo Gomes de Lima, PhD, have now identified the precise location where human chromosomes break and recombine to form Robertsonian chromosomes. Their findings explain how these rearrangements form and remain stable—but also point to how repetitive…

Study highlights functional preservation in patients and signals the potential for pre-symptomatic intervention. For decades Huntington’s disease has stood as both a genetic certainty and a model of accelerated cellular aging; new clinical trial data now show that decline can be delayed. Results released by uniQure demonstrate that AMT-130, an experimental gene therapy delivered in a single neurosurgical session, slowed clinical progression by 75 percent over three years in treated patients [1]. The pivotal Phase I/II study compared treated patients with propensity score-matched external controls from the Enroll-HD dataset. High-dose AMT-130 met its primary endpoint, showing a statistically significant slowing…

Hot air drying — a cheap and relatively easy preservation technique — improves the availability of key nutrients and plant compounds in microgreens that benefit health, according to new food research. When kept fresh, these highly nutritious young seedlings of cruciferous vegetables like radish, broccoli, and kale are highly perishable and lose nutritional value quickly. Microgreens contain nutrients such as vitamins, minerals, and bioactive antioxidants, like polyphenols and glucosinolates.“Microgreens increasingly are popular due to their high concentrations of health-promoting compounds, but their benefits have been limited because they’re highly perishable, lasting only one to two days at room temperature and…

The chemokine CXCL12 helps red blood cell progenitors achieve the final steps of maturation.Image credit:©iStock, CreativeDesignArtDonated blood is often in short supply, so to prevent dire blood shortages, scientists are figuring out a way to synthesize blood in the laboratory. However, researchers often face difficulties because they can’t effectively induce enucleation, a crucial process in mammalian red blood cell maturation. “So far, there is no soluble factor described which is able to trigger this enucleation process,” said Julia Gutjahr, a cell biologist at the University of Konstanz. Recently, Gutjahr’s team found that CXCL12, a signaling protein, may solve this problem.1…

Be the first to rate & review! This invisible apple cake gets its name from the French dessert Gateau Invisible aux Pommes. Layers of thin apple slices “disappear” into the custardy batter as it bakes to create one cohesive cake. Almond extract adds a slightly fruity note, while cinnamon brings warm spice. Serve with a scoop of vanilla ice cream or whipped cream on top. Published on September 24, 2025

Japanese walking can improve your health with just 30 minutes of intervals a day.This method improves blood pressure, endurance and strength over time.This 5-day plan makes it easy to fit this efficient workout into daily life. More than 75% of Americans fall short of meeting the recommended physical activity guidelines for both aerobic and strength training exercise, often citing lack of time as the biggest barrier. Fortunately, there’s growing interest in different forms of exercise that make it easier to get moving. One trend is Japanese walking, a form of walking that has real research to back it up, including…

A new law is being proposed to prevent coverups by public servants when things go wrong. Clare Dyer explains what it could mean for the health serviceThe new Public Office (Accountability) Bill—known as the Hillsborough law and named after the football stadium disaster—promises to help prevent coverups in the public sector, including the NHS.The health service is no stranger to scandal, with a recurring theme being the time it takes authorities to find out what went wrong. Robert Francis provided one answer in his 2013 report on serious harm to patients at Mid Staffordshire NHS Foundation Trust, which found that…