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Credit: libre de droit / Getty Images Different variants of a gene, known as isoforms, can be transcribed and translated at varying levels within a cell or tissue. These isoforms are commonly a result of alternative splicing, which produce distinct protein products with potentially different functions and expression patterns. Analyzing isoform expression is crucial for understanding cell-type identity, disease mechanisms like cancer, and the impact of genetic variations.  While current RNA-seq methods for quantifying isoform expression depend heavily on pre-existing transcript annotations, thousands of potentially disease causing unannotated isoforms are actively expressed in each sample, remaining invisible to traditional approaches.   At…

Sheet-pan dinners are the perfect solution to busy weeknight meals, and these highly-rated recipes spotlight the comforting flavors of fall. Brussels sprouts, sweet potatoes and broccoli shine in these tasty dishes with four- and five-star ratings. Recipes like our Maple-Roasted Chicken Thighs with Sweet Potato Wedges and Brussels Sprouts or our Sheet-Pan Spiced Chickpeas & Sweet Potatoes with Herby Yogurt are delicious and healthy meals you’ll want to make again and again. Love these recipes? Join MyRecipes to save them all with one click. It’s so easy—and free!  High-Protein Sheet-Pan Salmon with Broccoli Ali Redmond Fresh, fast and full of…

The prime minister, Keir Starmer, has ordered a rapid review of how healthcare regulators such as the General Medical Council deal with allegations of racist or antisemitic behaviour in the NHS. The government will also roll out mandatory antisemitism and antiracism training for all 1.5 million NHS staff and has promised a “zero tolerance” approach to discrimination in healthcare.The move follows a case in which a British-Palestinian trainee doctor, Rahmeh Aladwan, was allowed to continue practising pending a full Medical Practitioners Tribunal Service hearing into allegations that she made antisemitic remarks.1Aladwan, who has continued to comment on social media, has…

Hong Kong researchers say certain dietary fatty acids may “supercharge” the human immune system’s ability to fight cancer. They discovered that oleic acid, an omega-9 fatty acid found in olive oil and nuts, boosted immune γδ-T cells in cancer patients undergoing γδ-T cell therapy. These cells are known for their cancer-fighting properties.Conversely, they found that another fatty acid, called palmitic acid, commonly found in vegetable  fats like palm oil and fatty meats, weakens the ability of these immune cells to attack tumors. Oleic acid may help prevent this from happening.“Our research suggests that dietary fatty acid supplementation, particularly with foods…

Immunoassays help researchers visualize important biological elements, allowing them to judge the relationship or quantities of specific antigens.©iStock, WirestockScientists rely on immunoassays in diverse settings, from basic research to clinical diagnostics and biopharmaceutical analysis.1 This article explores immunoassay principles, types, applications, and emerging trends that define modern laboratory practices.What Is an Immunoassay?Immunoassays are measurement procedures that use immune-based reagents to generate a detectable signal, allowing scientists to quantify biological processes. Scientists perform immunoassays to measure biological targets, pathway activity, and cellular phenotypes.2To label targets, immunoassays depend on the interaction between an antibody and its target antigen’s binding site, known as…

I used to work in kitchens, and I will never forget the day I completely wiped out in front of my entire kitchen team one summer. I was walking to the dishroom to grab a new mixing bowl. On a mission, I reached for the bowl, turned around, and began walking. My heel hit the ground, and the next thing I knew, my crisp, white chef’s jacket was mopping the floor. My friend helped me up, and for the entirety of my shift, I had a huge brown spot on my coat and butt—thanks to the dish water—that looked a…

Dina Radenkovic Turner, MD Gameto’s CEO and co-founder Any woman who has frozen her eggs or undergone in vitro fertilization (IVF) to try and get pregnant knows how challenging and time consuming the process can be. This is something Gameto’s CEO and co-founder Dina Radenkovic Turner, MD, is trying to change. The company’s lead candidate treatment Fertilo is currently in Phase III trials in the U.S. and already has approval in several other countries. It aims to cut the time needed for ovarian stimulation and egg collection from two weeks to a few days by using engineered ovarian support cells…

High cholesterol is common, with about 10% of U.S. adults having the condition.Foods high in soluble fiber, like these frozen veggies, may help reduce cholesterol levels.Stock up on frozen edamame, broccoli, cauliflower, Brussels sprouts and more. High cholesterol affects about 10% of U.S. adults; having it puts you at a higher risk of developing heart disease and stroke. When it comes to managing high cholesterol, small dietary changes can help. Eating enough vegetables not only helps reduce high cholesterol but may even prevent the condition. While many people believe that fresh veggies are healthiest, frozen veggies with no added ingredients…

American pharmaceutical giant Eli Lilly has said it will crack down on suppliers who are selling fake versions of its unapproved weight loss drug retatrutide.Social media companies TikTok and Meta have also intervened against black market sellers operating on their platforms.The decision comes after a Channel 4 investigation found that patients have been able to buy fake versions of retatrutide on social media.1 The triple glucagon hormone receptor agonist drug is currently in phase 3 clinical trials, set to conclude in May 2026.2As a glucagon-like peptide-1 receptor agonist, it is similar …

Grapefruit provides significant amounts of vitamins A and C and is relatively low in calories and low on the glycemic index, making it a nutritious fruit choice for diabetics. Eating grapefruit may also help you better control your blood sugar levels, but if you take certain medications, you may be better off choosing a different fruit because of potential medication interactions. Carbohydrate Content Half of a large grapefruit has 53 calories and 13.4 grams of carbohydrates, including 1.8 grams of fiber. If you control your blood sugar by counting carbohydrates, this counts as one carbohydrate serving. Diabetics can typically have…