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Have you ever opened a medical bill and felt your heart drop? You are certainly not alone. Most people find navigating the medical system more stressful than the actual illness. In fact, Americans’ challenges with health care have become a defining feature of modern life in the United States. We spend more than any other nation. However, our outcomes often lag behind our peers. Why is there such a massive disconnect? What is the biggest problem with US healthcare today? Many of my patients feel the system is a maze designed to confuse them. What do Americans think about their…
Chronic constipation is one of the most common disorders of gut-brain interaction, affecting around one in ten adults worldwide. It has a substantial impact on quality of life and is associated with economic burdens, including direct costs and lost productivity1. Emerging evidence suggests that gut transit time is a key factor in shaping the gut microbiota composition and metabolic activity, which is likely to have implications for constipation and long-term gut health. While people often first try dietary changes to manage constipation symptoms, existing guidelines for constipation management generally include limited dietary advice, focusing mainly on increasing fiber intake and…
Altimmune raises $75 million to advance pemvidutide, a promising therapy tackling serious liver and metabolic diseases. For most, liver disease is a background noise – a shrug-worthy diagnosis until it precipitates a catastrophic systemic failure. Yet metabolic dysfunction-associated steatohepatitis (MASH) is increasingly the silent engine of the modern metabolic crisis. It is an insidious pathology, a slow-burn accumulation of lipids and fibrotic scarring fueled by the chronic insults of obesity and type 2 diabetes. The danger lies in its invisibility; MASH doesn’t announce itself with a bang, but with the quiet, structural remodeling of the liver’s architecture. By the time…
From a young age, Daniel Khosravinia tinkered and built numerous LEGO models, from knights to the Star Wars Death Star. This sparked his interest in how things are built, and when he learned about the structure of DNA in high school, he thought about how to bridge the two. “I wanted something for LEGO science…but the closest sets that I could find were LEGO space, and how many rockets are you going to build?”This inspired Khosravinia, who went on to complete his bachelor’s degree in biomedical science at King’s College London—a historic location where the structure of DNA structure was…
Egg salad is a beloved staple of picnics, deli counters, and quick weekday lunches. Whether it is a creamy, mustard-heavy classic or a modern yogurt-based twist, the combination of protein-rich eggs and fat-based binders makes for a delicious meal. However, because its primary ingredients are highly perishable, it is also a frequent source of concern regarding food safety. If you have ever stared at a container in the back of your refrigerator, wondering, how long is egg salad good for?, you are not alone. The short answer, supported by the USDA and food safety experts, is that egg salad is…
Cardiff Oncology (NASDAQ: CRDF) this past week trumpeted positive data via press release from a Phase II trial of its lead pipeline candidate, onvansertib, in two standard-of-care (SoC) combination regimens in first-line RAS-mutated metastatic colorectal cancer (mCRC). But another announcement issued the same day by Cardiff jolted investors enough to spark a stock selloff that sent the cancer drug developer’s shares nosediving 45% over two days: Cardiff’s CEO Mark Erlander, PhD, and CFO James Levine have stepped down, with Erlander succeeded by an interim CEO, Mani Mohindru, PhD, a member of Cardiff’s board since 2021. Cardiff has begun searching for…
This Symposium will be hosted live and available on-demandMay 19-20, 2026 11:00 AM – 3:00 PM ETInfectious disease researchers employ diverse approaches to study pathogen biology, examine host-pathogen interactions, and discover potential therapeutic targets. Register now to reserve your spot!
Since it was first detected in the United States in 2014, H5N1 avian influenza, commonly known as bird flu, has jumped from wild birds to farm animals and then to people, causing more than 70 human cases in the United States since 2024, including two fatalities. The virus continues to circulate among animals, giving it the opportunity to develop the ability to spread among humans and potentially cause another pandemic. To mitigate the risk of such an event, researchers at Washington University School of Medicine in St. Louis (WashU Medicine) developed an intranasal avian influenza H5N1 vaccine that elicited strong…
PMD trial ties functional measures with NAD⁺ and redox biomarkers, offering a pragmatic view of mitochondrial modulation. Primary mitochondrial disease (PMD) rarely attracts broad attention outside specialist circles, yet it sits uncomfortably close to the fault lines of modern geroscience. When mitochondria fail, energy falters, redox balance skews and physical function degrades in ways that look uncomfortably familiar to anyone studying aging. New results from OMEICOS Therapeutics’ PMD-OPTION study therefore resonate beyond the confines of rare disease, even as the company is careful to frame its work firmly within a defined clinical indication. The Phase 2a PMD-OPTION trial evaluated OMT-28,…
Time-resolved fluorescence resonance energy transfer (TR-FRET) combines fluorescence detection with temporal resolution to significantly enhance assay performance. This technology minimizes background interference and boosts sensitivity in biochemical assays, making it especially effective in kinase screening and protein interaction studies, where its homogeneous format supports rapid, high-throughput applications.Emily Peng, PhDSenior Product ScientistSino BiologicalIn this Innovation Spotlight, Emily Peng, a senior product scientist at Sino Biological, discusses how, through ready-to-use kits and compatibility with automation, TR-FRET assays streamline workflows and drive more confident decision-making in early drug development.What is TR-FRET, and how does it work?TR-FRET is a fluorescence-based detection technology used to…