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Engineered prime editors display significantly improved edit to indel ratios, making them an attractive alternative for therapeutic applications.Image credit:©iStock, TanyaJoyPrime editing is an attractive alternative to CRISPR-Cas9 gene editing because it can rewrite sections of DNA without the risks associated with introducing double-stranded breaks.1 However, prime editing can still introduce errors, such as insertion and deletion mutations (indels), presenting a key obstacle to its adoption in cell and gene therapies.1In a new study published in Nature, researchers from the Massachusetts Institute of Technology (MIT) showcased engineered prime editors with significantly lower rates of indel formation. “This paper outlines a new…

I love starting my morning with a workout. It forces me to get out of bed, sets a positive tone for the rest of the day and, ideally, allows me to breathe fresh air before I sit in front of a computer for eight consecutive hours. In fact, I love it so much that rarely a day goes by that you won’t find me walking my dog, walking to a workout class or simply walking around for the heck of it.  Now that fall is almost here, bringing chilly temperatures with it, I wanted to share some of my favorite…

Telomeres act like the plastic tips on shoelaces, preventing DNA from fraying. As they shorten, cells become more vulnerable to damage, driving aging and increasing the risk of chronic diseases such as diabetes, cardiovascular disease, and metabolic dysfunction.

Y Tony Yang, endowed professor and associate deanGeorge Washington University, Washington, DC, USAytyang{at}gwu.eduJha and Psaki compellingly outline supply side breakdowns and demand side erosion in vaccination efforts, advocating for public health to reclaim digital spaces.1 Their recommended strategies—equipping health workers, leveraging community leaders, and dealing with political misinformation—are sound, but we need more transformative approaches targeting the root causes of mistrust in our evolving digital landscape.The traditional vaccine “trust deficit” reflects broader institutional disillusionment, not merely knowledge …

Credit: Juan Gaertner/ Science Photo Library/ Getty Images Brown adipose tissue is specialized for non-shivering thermogenesis—burning calories to produce heat. Its best-characterized mechanism relies on uncoupling protein-1 (UCP1) in mitochondria, which allows cells to “burn fuel without work.” Yet scientists have long observed that mice lacking UCP1 can still stay warm and resist weight gain, implying that alternative heat-generating systems exist. Finding those systems has become a priority as obesity and type 2 diabetes continue to rise worldwide. If physicians could safely raise a patient’s baseline energy expenditure, it might complement traditional weight-loss approaches focused on calorie intake and exercise.…

Bone broth is made by simmering bones for up to 24 hours to extract nutrients.It’s a source of protein and may support hydration, gut, skin and joint health.Enjoy it on its own as a cozy drink, use it as a soup base or add it to other dishes to boost flavor. Bone broth has been a cultural staple for thousands of years, used both to flavor dishes and as traditional medicine. “Traditionally, bone broths provide a warming element to meals along with comfort, especially in times of illness where they play a role in traditional medicine, reflect resourcefulness by using…

NewsA new artificial intelligence (AI) tool can forecast a person’s risk of developing more than 1,000 diseases. The model, called Delphi-2M, uses a person’s health records and lifestyle factors to estimate their likelihood of developing diseases such as cancer and immune conditions up to 20 years ahead of time. For many diseases, Delphi-2M’s predictions matched or exceeded the accuracy of those of current models that estimate the risk of developing a single illness. “It worked astonishingly well,” says data scientist and study co-author Moritz Gerstung.Nature | 5 min readReference: Nature paperNewsDeepSeek-R1, a cheap and powerful artificial intelligence (AI) ‘reasoning’ model…

Mikhail Lukin (right) and colleagues with their neutral-atom quantum computer.Credit: Rose Lincoln/Harvard Staff PhotographerA conveyor belt of atoms arranged in orderly rows could resolve a major stumbling block towards developing a large-scale quantum computer.Quantum-computing technology that makes qubits from atoms wins mega investmentIn a study published in Nature on 15 September1, physicists show that the system can continuously replace and replenish the individual atoms suspended in an array by laser beams called ‘optical tweezers’. Physicists have used such arrays to create some of the largest quantum computers to date — a technique called neutral-atom quantum computing — but the approach…

Colon cancer treatment often includes a combination of chemotherapy, immunotherapy, radiation, and surgery. While these therapies work to fight cancer cells, they can also interact with certain things you consume, including supplements.[1]Even supplements that seem harmless, like herbal and over-the-counter products, can increase the side effects of cancer therapies. Others can weaken treatment, making it less effective at fighting cancer.[2]Another reason to be cautious is that supplements in the United States aren’t regulated as strictly as prescription medications.[3] Labels may be inaccurate, certain ingredients may not be listed, or the amounts may be different from what’s advertised. Plus, if you’re healing…

In manufacturing, intensification is an attractive idea. The ability to make more product, for less, using fewer resources, makes economic sense. In practice, however, it is a complex undertaking that involves rethinking all parts of the process. Courtney Hazelton-Harrington, a senior R&D scientist at Lonza Biologics, looked at process intensification in a new study and found that analytical technologies with the capacity to operate at high-throughput are a key component. “Bioprocess intensification means making biomanufacturing more productive, efficient, and sustainable, using continuous processes and advanced technologies to produce more product per unit space, time, and cost,” she told GEN after…