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Nature, Published online: 07 October 2025; doi:10.1038/d41586-025-02978-wLively scientific debates found in correspondence from 1916 to 1918, and Saint Patrick’s snake-banishment skills are called into question in this week’s pick from the Nature archive.
This recipe transforms butternut squash into a rich, flavorful side to pair with meat, fish and more.This dish contains immune-boosting ingredients to help you fight off disease and illness.For a different spin on the recipe, try it with chopped pumpkin instead of butternut squash. This Garlic-Butter Butternut Squash is the perfect side for your favorite protein. Antioxidant-rich butternut squash becomes sweet and slightly caramelized from roasting, while the garlic mellows out and gains a creamy texture before being whisked into melted butter and drizzled over the squash. Italian seasoning adds its classic flavors, which meld wonderfully with the roasted garlic.…
New research finds that microplastics can change the human gut microbiome, causing patterns linked to depression and colorectal cancer. The gut microbiome is a major focus in nutrition, as it holds the key to overcoming several health issues. The study, conducted under the CBmed research center and its international partners’ microONE research project, is touted to be among the first to directly study how different types of microplastics interact with the human gut microbiome.The researchers examined stool samples from five healthy volunteers, which were used to grow ex vivo gut microbiome cultures exposed to common microplastics. They found that the…
From startups to giants in pharma and tools, the use of spatial biology is growing in importance in drug discovery. LatchBio, a four-year-old San Francisco builder of software and data infrastructure for biopharmas, on September 5 announced its release of a 25-million-cell atlas for spatial transcriptomics covering 45 tissue types, 63 diseases, and 11 spatial technologies—the largest open-source human spatial atlas to date, according to the company. Among pharmas, GlaxoSmithKline (GSK) applies Relation Therapeutics’ Lab-in-the-Loop platform, which integrates spatial and single-cell transcriptomics with tissue profiling, sequencing, and target validation—then combines those with multi-modal patient data, perturbational omics and translational cellular…
Senior Beauty & Lifestyle DirectorAlexandra Engler is the senior beauty and lifestyle director at mindbodygreen and host of the beauty podcast Clean Beauty School. Previously, she’s held beauty roles at Harper’s Bazaar, Marie Claire, SELF, and Cosmopolitan; her byline has appeared in Esquire, Sports Illustrated, and Allure.com.
Bethanie Carney Almroth, professor of ecotoxicologyDepartment of Biological and Environmental Sciences, University of Gothenburg, SwedenWe need to put humans and the environment before corporate profits, writes Bethanie Carney AlmrothPlastics have become a concern at the forefront of public environmental awareness campaigns and in political discussions. Nations of the world convened in Geneva, Switzerland, in August 2025 to negotiate a globally binding United Nations treaty intended to end plastic pollution across the full life cycle—from production to disposal.1 It had been three years since heads of state agreed on a mandate to create this historic treaty, but although the sixth round…
Characterizing how neuronal genomics change over time in healthy brains may help researchers better understand how aging affects cognitive function.Image credit:© iStock, BlackJack3DBiological aging undeniably affects human cognitive function.1 However, how this happens—the underlying factors, interactions, and processes—remains unclear. Michael Lodato, a geneticist from the University of Massachusetts (UMass), thinks somatic mutations—mutations that occur over an individual’s lifetime—play a key role in this phenomenon. In a study recently published in Nature, he and his research team conducted a detailed investigation of the genetic and genomic dynamics of the human brain across the lifespan, from infancy to centenarian.2 They found that…
Staphylococcus aureus is listed as a high-priority pathogen by the World Health Organization.Credit: Dennis Kunkel Microscopy/Science Photo LibraryAntimicrobial resistance (AMR) is projected to cause 39 million deaths worldwide over the next 25 years. But global efforts to find treatments for drug-resistant infections are not going to plan, according to two reports from the World Health Organization (WHO) released on 2 October1,2. The reports show that the global antibiotic drug-development pipeline is facing a dual crisis: a scarcity of drugs in development and a lack of innovation in methods to fight drug-resistant bacteria.“Antimicrobial resistance is escalating, but the pipeline of new…
Credit: Elva Etienne/Getty Images Research led by Beckman Research Institute of City of Hope shows that altered expression of the SMOC1 gene promotes a physiological change leading to higher blood sugar and decreased insulin expression and secretion in the body, as seen in type 2 diabetes. Writing in Nature Communications, the team explained that higher expression of SMOC1 led to insulin-producing beta cells in the pancreas transforming into glucagon-producing alpha cells. This is a phenomenon seen in people with type 2 diabetes leading to higher blood sugar levels, as glucagon acts to boost blood sugar and lower levels of insulin,…
Manjit Sareen reflects on the first Asia-Pacific Longevity Medicine International Summit and the launch of a global directory for clinics. There was a palpable sense of optimism in Hong Kong as experts from around the world gathered for the region’s first Longevity Medicine International Summit – a moment that signalled how far the field has come, and how much potential still lies ahead. The first-ever Asia-Pacific Longevity Medicine International Summit (APAC-LMIS) in Hong Kong marked an important milestone for the region – bringing together clinicians, researchers, innovators and industry leaders to advance the science and practice of longevity medicine. For…