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Depression is a debilitating mental health disorder that remains a substantial global health challenge. Despite the availability of various antidepressants, treatment outcomes often face limited efficacy, delayed onset of action, and adverse effects. These drugs focus on regulating neurotransmitters, especially serotonin, and benefit only about half of patients. This limitation emphasizes the need to search for new molecular pathways in the brain beyond neurotransmitter signaling to treat mental health disorders. In a new study published in Science Advances titled, “Abnormal O-glycan sialylation in the mPFC contributes to depressive-like behaviors in male mice,” researchers from the Institute for Basic Science (IBS)…

Add rice back into your meal rotation without the worry.

Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi won this year’s Physiology or Medicine Nobel Prize.Image credit:https://www.nobelprize.org/Mary Brunkow, a molecular biologist at the Institute for Systems Biology, Fred Ramsdell, an immunologist at Sonoma Biotherapeutics, and Shimon Sakaguchi, an immunologist at Osaka University won this year’s Nobel Prize in Physiology or Medicine for their discoveries concerning how immune tolerance prevents the immune system from attacking the body, the Nobel Assembly at the Karolinska Institute announced today (October 6). Their discoveries lay the foundation for new and improved treatments for autoimmune disorders and cancers.“Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi have provided fundamental…

Your saturated fat intake may not be top of mind, but overdoing it can manifest in subtle ways.Excessive saturated fat can impact digestion, mood, energy and even your skin health.To balance your intake, swap butter for olive oil and fill your meals with produce, whole grains, nuts and seeds. Many of us don’t think about our saturated fat intake on a daily basis, but it often finds its way into our diet. From the butter on your toast to the cheese on your pizza, it’s in more foods than you may think. In fact, two-thirds of Americans overdo it on…

The post Menopause & microbes: can your gut help ease your symptoms? appeared first on The Gut Health Doctor.

Great walking and running shoes can be pricey, especially when it comes to top brands like Brooks. Its reliable, oftentimes podiatrist-approved shoes are made for a wide range of movement, whether for daily walks or track runs. Rarely do we see Brooks shoes available for under $100. Today, during Amazon’s October Prime Day, we found a pair that’s well below the brand’s typical price. In fact, it’s as low as $70—a price I have never seen when it comes to new Brooks shoes. Best of all, the Revel 7 has rave reviews and podiatrists’ seal of approval. Brooks Revel 7…

One of them even includes eating dessert.

AbstractObjective To test the hypothesis that non-invasive high frequency oscillatory ventilation (NHFOV) is more efficacious than nasal continuous positive airway pressure (NCPAP) in reducing invasive mechanical ventilation as primary respiratory support for extremely preterm infants with respiratory distress syndrome.Design A multicentre, randomised controlled trial.Setting Twenty tertiary neonatal intensive care units in China.Participants 342 extremely preterm infants (gestational age between 24 weeks +0 day and 28 weeks +6 days) with respiratory distress syndrome were enrolled in the study between August 2022 and August 2024.Interventions Participants were randomly allocated to receive NCPAP or NHFOV as primary respiratory support for respiratory distress syndrome.Main…

Mars is the planet of action and energy in astrology, and when it moves into a new sign, we can all feel our priorities and motivations shift. For the past nearly two months, with Mars in Libra, we may have been feeling more susceptible to romanticizing, for instance.

In the 1960s, scientists classed chimpanzees, bonobos, gorillas and orangutans as a distinct family (Pongidae), thinking that these great apes had long diverged from humans. Few scholars expected that, in nature, these apes would display strikingly human-like behaviour. Jane Goodall, who has died aged 91, overturned this view with her groundbreaking observations of wild chimpanzees (Pan troglodytes).Jane Goodall’s legacy: three ways she changed scienceHer discoveries foreshadowed the genetic evidence showing that chimpanzees, bonobos (Pan paniscus) and humans are more closely related to one another than to gorillas (Gorilla spp.) and orangutans (Pongo spp.). The findings had a major role in…