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Credit: OGphoto/Getty Images Researchers at the Hebrew University of Jerusalem have developed a new method to detect aggressive and metastatic cancer cells by how they physically interact with specially textured Meta surfaces patterned with tiny immobilized particles. The research, published in the journal Materials Today Bio, found that more aggressive cancer cells gripped the nanoparticle embedded on the surface more strongly, swallowed more particles and altered their shape in ways that were different from less aggressive cells. The breakthrough could significantly improve current cancer diagnostic methods that largely rely on genetic or protein markers for diagnosis. The study was led…

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Digestive discomfort is a universal experience, but few issues are as frustrating and physically taxing as constipation. When the digestive system slows down, the immediate search for a natural remedy often leads to the kitchen pantry. One of the most common questions asked of pediatricians and nutritionists alike is: Does apple juice help with constipation? The short answer is yes. Apple juice has been a staple home remedy for generations, recognised for its gentle yet effective ability to move the bowels. However, the efficacy of this remedy depends on more than just drinking a glass of juice; it involves a…

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When our body fights an infection, the immune system must quickly activate defenses and trigger a beneficial inflammatory response. It’s just as important to be able to resolve that inflammation and return to homeostasis. Macrophages play a key role in this balance. These immune system cells specialize in phagocytosing, or engulfing, cells that have died due to viral infection and in repairing infection- or inflammation‑related tissue damage. A preclinical study conducted at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) has now uncovered the mechanism by which a signal associated with antiviral and inflammatory responses—type I interferon (IFN‑I)—tunes macrophage…

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Scientists modified commensal gut bacteria to glow bright under healthy conditions and dim under stressful ones, developing a potential tool for early diagnosis of gut diseases.Image credit:© iStock.com, Mohammed Haneefa NizamudeenThe mammalian gut is a dynamic environment, wherein shifts in the local environment can lead to disease. Despite the importance of monitoring biochemical parameters in the gut, the most commonly used tools are invasive endoscopic methods, which provide information at only one point in time. To overcome this, Carolina Tropini, a microbiologist at the University of British Columbia, and her team engineered gut bacteria that would dim their fluorescence under…

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Credit: Lars Neumann / iStock / Getty Images Plus Researchers at the University College London (UCL) have identified a central target for immune cells found in the gut in the early development of Parkinson’s disease. Working in mouse models, the team found that muscularis macrophages in the gut engulf misfolded alpha-synuclein, become dysfunctional, and promote immune responses that enable disease pathology to travel along the gut–brain axis. The findings, published in Nature, show that immune cells are active participants in Parkinson’s development and progression, and provide a new therapeutic target that could alter disease development before motor symptoms appear. “Our…

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Personalized nutrition pioneer brings 3D-printed gummies and live demos to London as longevity moves from theory to everyday practice. Rem3dy Health has been named an official partner for The Longevity Show 2026 this June, marking another step in the steady migration of personalized nutrition from niche innovation to mainstream longevity discourse. Founded in the UK in 2019, the company is best known for its flagship brand Nourished, which uses patented 3D-printing technology to produce personalized nutrient gummies tailored to individual needs, preferences and health goals. At the upcoming Longevity Show, Rem3dy Health will bring both spectacle and substance. Founder and…

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Organoids have helped create a comprehensive map showing how eight different genetic mutations associated with autism spectrum disorder affect early brain development. This work provides new insights into the ways diverse genetic causes may lead to shared features and symptoms of the disorder. Over the past two decades, more than 100 genes harboring rare mutations linked to autism have been identified. This genetic heterogeneity has raised a fundamental question: if autism can be caused by so many different genetic changes, why do individuals with autism often share common features? A new study published in Nature in the paper, “Developmental convergence…

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Credit: Nikita John Creagh / Getty Images Researchers in the U.K. have developed a novel prognostic tool based on magnetic resonance imaging (MRI) that could remove the need for invasive catheterization techniques used nowadays. A study published today in JACC Advances shows that this new method yields comparable results to heart catheter tests and can accurately predict future outcomes in patients diagnosed with advanced heart failure.  “We wanted to develop a safe, non-invasive alternative which could allow far more patients to be properly assessed—and allow repeat monitoring without the risks of a catheter test,” said Pankaj Garg, MD, PhD, associate…

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