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RESEARCH BRIEFINGS 01 October 2025 After an initial treatment response, most ovarian cancers recur because of drug-resistant cell populations. Blood-based tracking, used to monitor clonal evolution in 18 patients, shows that drug-resistant clones are already present at diagnosis, expand during therapy and contain distinctive genomic alterations that have potential therapeutic relevance.

Your treatment plan is likely to evolve after you’re diagnosed with SPMS.If you have active SPMS, your doctor may suggest treatment with disease-modifying therapies (DMT). The good news: More than 20 DMTs are available to help you manage the condition.[2] These drugs are designed to reduce the speed of symptom recurrence and stave off nerve damage, but they don’t cure SPMS, unfortunately.Treatment may look a bit different if you have inactive or nonrelapsing SPMS, which has historically been harder to treat. “Until recently, no DMTs have provided significant delay in disability in those dealing with inactive SPMS,” says John R.…

Increasing evidence suggests that the geographical centre of medical research might be moving, as the amount and quality of research produced by China’s research hospitals rises, and the United States’ grip on the sector loosens.China increased its investment in science by more than 3,800% between 1996 and 2023, says Bilal Demirel, who studies science and innovation at the Rathenau Institute in The Hague, the Netherlands, and is now coming close to matching what the United States spends. With China currently increasing its annual R&D budget by 7% — while US funding looks set to fall under President Donald Trump —…

Heidelberg-based PromoCell reports that it has adopted custom GMP cell culture media services tailored for clinical applications and further manufacturing in the cell-based therapy industry. The company is offering excipient GMP-grade cell culture media manufacturing and guidance through the entire research-to-commercialization journey, according to Irma Börcsök, CEO. “We noticed an increasing demand for advanced cell culture media in regenerative medicine and cell-based therapy, and we are thrilled to introduce our GMP cell culture medium service portfolio to the life science community at the ESGCT Congress,” said Börcsök. “We’ve worked closely with our clients in clinical applications to ensure that both…

Startup’s ‘brain shuttle’ tech is designed to efficient, repeatable delivery of genetic medicines across the blood–brain barrier. Irish biotech Aerska has emerged from stealth with $21 million in seed financing as it seeks to advance new RNA interference medicines specifically designed to reach the brain. Based in Dublin with research operations in London, the company is focused on tackling one of the most intractable problems in medicine: delivering genetic therapies across the blood-brain barrier to treat neurodegenerative diseases. RNAi has already reshaped the treatment landscape for liver and cardiometabolic disorders, but its potential in neurology has been constrained by delivery…

Data published in the Frontiers in Nutrition indicated that 600 mg per day of PEA improved heart rate variability (HRV), a measure of stress. “This exploratory study demonstrates for the first time that PEA supplementation may enhance physiological resilience to stress as indicated by improved HRV,” wrote researchers from the University of Westminster, Anglia Ruskin University and Coventry University in the UK. “While subjective stress and emotional measures did not show significant changes, the observed trend suggests potential benefits in individuals experiencing moderate stress.” PEAInterest in the endocannabinoid system has grown significantly in recent years. For companies seeking to influence…

October arrives with the spaciousness we’ve needed; No more eclipses and planetary wild cards crammed into a small window. With the Sun drifting through diplomatic Libra until October 22, the cosmos calls for grace under pressure and a willingness to see the other side. Here’s your monthly horoscope.

Since their first descriptions in the 17th century, cells have fascinated scientists, despite being invisible to the naked eye. When virologist Joe McKellar began studying influenza viruses and cellular restriction factors during his doctoral studies at the French National Center for Scientific Research, he found himself drawn to the microscope. These human liver cancer cells, when grown on Poly-L-Lysine coated glass, become flattened and send out wild, spiky actin protrusions. Joe McKellar, Institute of Molecular Genetics of Montpellier, French National Center for Scientific ResearchPeering through its eyepieces, he quickly became captivated by the world of imaging. “It got me interested…

I watched the 2024 Wicked movie shortly after it began streaming. The timing was perfect—I was days into my first run-in with Coronavirus and was the sickest I had been in years. My body was weak, and I, quite honestly, was depressed and desperate to relieve COVID symptoms. A nearly three-hour movie filled with whimsy was exactly what I needed to bring some life back to my soul. Strong characters, like Glinda and Elphaba, and thoughtfully built worlds tend to evoke that in people. And honestly, Le Creuset Dutch ovens do just the same for many (me included). It makes…

engineer using digital tablet working late night shift at petroleum oil refinery in industrial estate. Shift work could put people at risk of developing kidney stones, according to researchers who say that these types of occupations should be targeted for lifestyle interventions. The risk of kidney stones was particularly great for those who worked nights, report by Man He, from Sun Yat-sen University, Guangzhou, China, and colleagues in the Mayo Clinic Proceedings. It was also greater for younger people and lower with longer durations of shift work, possibly because adjusting and adapting to shift work results in healthier lifestyles that…