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Bispecific antibodies and chimeric antigen receptor (CAR) T cells demonstrate potent cancer immunotherapy in clinical use, yet most cancers remain poorly targetable. High-affinity antibodies needed to maximize cancer killing also detect low antigen expression in normal tissue, which causes toxicity in healthy tissue. Identifying cancer-restricted cell-surface protein antigens remains an ongoing challenge.  In a new study published in Cell titled, “Safe immunosuppression-resistant pan-cancer immunotherapeutics by velcro-like density-dependent targeting of tumor-associated carbohydrate antigens,” researchers from the University of California (UC), Irvine, have reported that targeting cancer-associated glycans with binding proteins can trigger tumor cell death without toxicity to surrounding tissue. The…

The offspring of longer whale mothers are more likely to be female than those of shorter mums1. Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $32.99 / 30 days cancel any time Subscribe to this journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout Additional access options: doi: https://doi.org/10.1038/d41586-025-03053-0 Subjects Latest on:

Credit: Lars Neumann/Getty Images Researchers at the University of Southern California (USC) have developed a noninvasive method to measure the rhythmic pulsations of the brain’s smallest blood vessels, which was impossible until now in live human brains. In a study published in Nature Cardiovascular Research, the new technique revealed a link between an increase in pulsations in the brain’s microvessels and signs of aging and neurodegeneration, especially in deep white matter regions.  “Arterial pulsation is like the brain’s natural pump, helping to move fluids and clear waste,” said Danny J. J. Wang, PhD, professor of neurology and radiology at the…

For the past decade, healthcare providers have recommended that people who’ve had skin cancer take a form of vitamin B3 called nicotinamide, following a 2015 study that showed the supplement could lower the risk of new skin cancers.[1] New research affirms these findings with a much larger study group.[2]The new investigation found an “overall benefit for nicotinamide used to prevent skin cancer,” says study author Lee Wheless, MD, PhD, an assistant professor of dermatology at Vanderbilt University Medical Center in Nashville and a staff physician at the Tennessee Valley Health System Veterans Affairs Medical Center.Some people getting nicotinamide especially benefited.…

One of Australia’s most iconic species, the koala is staring down the barrel of extinction. Among a barrage of other threats, including deforestation, attacks by wild and domestic dogs, and traffic collisions, koala populations are being decimated by chlamydia. The sexually transmitted bacterial infection affects about 50 percent of koalas across Australia and can be fatal.1Now, after more than a decade of research, scientists from the University of the Sunshine Coast (UniSC) have received approval for a single-dose chlamydia vaccine that they hope will turn the tide. “This is the first chlamydia vaccine for koalas,” said Sam Phillips, a molecular…

Following a heart-healthy eating pattern doesn’t mean you have to miss out on your favorite comfort foods. These heart-healthy dinner recipes bring all the cozy vibes you love, with lower amounts of saturated fat and sodium. Whether you’re in the mood for a bowl of piping hot soup, creamy pasta or hearty casserole, there are plenty of options to hit the spot. Try our Chicken Parmesan Casserole or our High-Protein Pasta with Peas for the ultimate satisfying and comforting meal. Love any of these recipes? Join MyRecipes to save, search and organize your EatingWell recipes all in one place. It’s…

The firm was the first company globally to adopt the groundbreaking fiber-based screw top closures when it trialled them in its Magnesium product line last year. After the soft launch proved a success, both in terms of product quality, shelf stability and market response, the company has committed to the green alternative and exchanged all its plastic caps. Developed by Swedish start-up Blue Ocean Closures, the closures are 95% fiber content, allowing Great Earth to reduce its plastic use by 2.6 tons annually and significantly lower the carbon footprint of its supplement packaging“The collaboration with Blue Ocean Closures was a…

Be the first to rate & review! This one-pan chicken and rice skillet packs in protein, greens and flavor for a complete meal that comes together with minimal fuss. It’s a weeknight dinner that’s satisfying and delicious. And the best part? Everything cooks in a single skillet, making cleanup a breeze. Published on September 26, 2025

Expanding from oncology into neurodegeneration, company leverages tiny extracellular vesicles to enhance blood-based biomarker discovery. Precision medicine biotech FYR Bio has closed an $8 million financing round to accelerate its expansion into neurodegenerative disease research, extending the company’s biomarker discovery platform beyond its roots in oncology. FYR’s shift into neurodegeneration underscores a broader push in the field toward minimally invasive diagnostics that can capture the complexity of brain diseases. The Montana-based biotech has developed a precision medicine platform built around extracellular vesicles, or EVs – nanoparticles released by cells that carry proteins, RNA and DNA reflecting the molecular state of…

Many EU consumers do not meet daily recommended intake levels for essential vitamins and minerals, according to a recent peer-reviewed paper. The authors argue that food supplements can play a critical role in offsetting these gaps, specifically in vulnerable groups, and help reduce healthcare costs by reducing disease risk and improving workforce productivity. They say that deficiencies and insufficiencies are common, especially among children, older adults, pregnant and lactating women, and people following restrictive diets. The authors add that nutrient gaps impact resilience, productivity, and healthcare costs, but their health and economic consequences “remain under-recognized” in public policy. “Our paper highlights…