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Creatine is a well-researched, safe and effective supplement that may help athletic performance and your brain.Higher doses aren’t necessarily better, and most experts recommend 3 to 5 grams per day, or up to 10 grams for athletes.Choose creatine supplements that are independently tested to ensure what you’re getting is what’s on the label. Everywhere you turn, creatine is making headlines. It’s the supplement of the moment, and many would argue its popularity is for good reason. Creatine is one of the most-studied supplements for athletes and active individuals, with studies indicating significant performance benefits. “Creatine helps replenish your muscles’ energy…
Nature, Published online: 12 November 2025; doi:10.1038/d41586-025-03583-7A polymer with a 2D molecular structure stacks into tightly packed layers — forming films of nanoscale thicknesses that are nearly impermeable to gases and moisture.
Credit: GSO Images / The Image Bank / Getty Images Researchers at Mayo Clinic have developed a new predictive tool that can estimate an individual’s risk of developing mild cognitive impairment (MCI), an early stage of memory loss that can often evolve into Alzheimer’s disease, years before the first symptoms show up. With a long list of Alzheimer’s drugs failing in late-stage clinical trials over the past two decades, research is increasingly focusing on improving our understanding and ability to detect the early stages of the disease, including asymptomatic and MCI phases. Some of the brain changes that lead to…
MaterialsTMC, melamine and N-Methyl-2-pyrrolidone (NMP) were open and stored in a N2-environment glovebox. All other reagents, including acetone, isopropyl alcohol (IPA), TFA, deuterated TFA, polystyrene (280 kDa), anisole, chloroform, hexane, dimethyl formamide and DMSO were obtained from commercial vendors and used as received. CD-flat holey carbon (8/2-hole pattern) grids used for TEM were purchased from Electron Microscopy Sciences.Synthesis of 2DPA-1 powderFor a typical 2DPA-1 powder with a high r value, we first mix 1 mmol of TMC with 1 mmol of melamine in a 40-ml glass vial. Using a magnetic stir bar, stir the contents in a N2-environment glovebox with 18 ml of NMP…
Miriam Kimpton, assistant professor, Tzu-Fei Wang, associate professorDepartment of Medicine, University of Ottawa at The Ottawa Hospital and Ottawa Hospital Research Institute, Ottawa, ON, CanadaCorrespondence to: M Kimpton mkimpton{at}ohri.caPatient preferences key to weighing benefits and risks of indefinite treatmentDetermining the optimal duration of anticoagulation treatment after a first event of unprovoked venous thromboembolism (VTE) remains challenging.1 Part of the difficulty lies in identifying patients who are most likely to benefit from extended anticoagulation, a treatment associated with lower VTE recurrence rates but at the cost of higher bleeding risk.234 Uncertainty remains because clinical trials and prospective studies on this topic…
It’s common to experience an increase in thigh size at a certain point in a new workout routine. This phenomenon is not exclusive to your thighs, but it can be more noticeable in that area for some people. Switching up your exercise routine or diet may help you achieve a more balanced approach. However, understanding your self-image and having some patience around self-image during body changes is essential. Understanding Hypertrophy The Science Behind Muscle Enlargement in Exercise From an aesthetic point of view, exercises can help you lose weight or build muscle, and in many cases, the workout will accomplish…
Relish trays have graduated from Grandma’s go-to appetizer to a modern crowd-pleaser. Unlike charcuterie boards, which spotlight cured meats, relish trays lean into crisp produce for a lighter spread. Think of them as a no-cook canvas: bright pickles, raw or blanched veggies, a swipe of creamy dip, plus a few wedges of sharp cheese and whole-grain crackers. Everything can be prepped quickly or ahead of time, then arranged just before guests arrive, so you get maximum flavor with minimal fuss. Whether you’re hosting a game-day gathering or adding color to your holiday buffet, recipes like our Chopped Waldorf Salad Dip…
Fluorescent microscope image of the proximal tubule, the part of the kidney that’s most affected by ceramides. [Luis Cedeño-Rosario] Serious damage to short-term kidney function, known as acute kidney injury (AKI) can be fatal and also increase the risk of irreversible chronic kidney disease. It may be triggered by stressors ranging from sepsis to heart surgery, and affects more than half of ICU patients. Researchers at University of Utah Health (U of U Health) have now reported the results of preclinical in vitro experiments and studies in live mice suggesting that AKI is triggered by fatty molecules called ceramides, which…
Ree Drummond preps nearly every dish ahead to ease stress on Thanksgiving Day.Her holiday menu includes classics like turkey, stuffing and two kinds of pie.Wednesday is the busiest prep day—including casseroles, pies and turkey brining. For those of us hosting Thanksgiving dinner (or any of the events surrounding it), it can be really difficult to come up with a “game plan.” You have to decide not only what dishes you’re making (or assigning out), but how much of everything to make. Unless you have a multi-oven kitchen with infinite burners, you need to come up with an order of operations…
Baxter, S. M. et al. Centers for Mendelian Genomics: a decade of facilitating gene discovery. Genet. Med. 24, 784–797 (2022).CAS PubMed PubMed Central Google Scholar Taylor, J. C. et al. Factors influencing success of clinical genome sequencing across a broad spectrum of disorders. Nat. Genet. 47, 717–726 (2015).CAS PubMed PubMed Central Google Scholar Wright, C. F. et al. Genomic diagnosis of rare pediatric disease in the United Kingdom and Ireland. N. Engl. J. Med. 388, 1559–1571 (2023).CAS PubMed PubMed Central Google Scholar Rimmer, A. et al. Integrating mapping-, assembly- and haplotype-based approaches for calling variants in clinical sequencing applications. Nat.…