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New DNA-encoded macromolecules snap together like molecular Lego blocks, providing precise control over shape and function in drug design.Image credit:istock, Elif Bayraktar Traditional approaches to drug development face trade-offs. Small molecules are cell permeable and easy to manufacture, but they often suffer from poor specificity and off-target effects. Antibodies and peptides tightly bind their targets but are large, costly to produce, and difficult to administer. To address these challenges, scientists at the startup company ThirdLaw Molecular developed synthetic molecules called Spiroligomers™, which combine the best properties of small molecules, peptides, and antibodies. Designing novel peptides for therapeutics has proven difficult, as…
Geneva College of Longevity Science President Dominik Thor on education, evidence and the adoption of longevity technologies. The Global Longevity Summit, entitled Mastering the Aging Clock: The Science of Longevity, will convene in Geneva this October, bringing together international leaders in science, medicine and innovation under the banner Transform Your Practice and Patient Care. With education and clinical adoption at its core, the event reflects a broader shift towards embedding longevity science into mainstream healthcare practice. Professor Dominik Thor, President of the Geneva College of Longevity Science (GCLS), will be among the keynote speakers. His focus: how cutting-edge innovation can…
Arnav Kapur, the CEO of AlterEgo, demonstrates the wearable device.Credit: AlterEgoA wearable device could make saying ‘Alexa, what time is it?’ aloud a thing of the past. The artificial intelligence (AI) neural interface called AlterEgo promises to allow users to silently communicate by just thinking words. Sitting over the ear, the device facilitates daily life through live communication with the Internet. “It gives you the power of telepathy but only for the thoughts you want to share,” says AlterEgo’s chief executive Arnav Kapur, based in Cambridge, Massachusetts. Kapur unveiled the device on 8 September.The device does not read brain activity,…
As many as 13% of people say that bloating is a problem. Probiotics may help by restoring the balance of good gut bacteria and aiding in digestion.They may also ease constipation and manage food sensitivities that can lead to bloating. We’ve all been there. You finish a meal and suddenly feel like you’ve swallowed a balloon. Your stomach feels tight, uncomfortable and noticeably larger than it was just an hour ago. Bloating affects up to 13% of us regularly, turning everyday activities into uncomfortable experiences. With the growing buzz around gut health, you may wonder if probiotics could be the answer…
Astrology can give us initial insight into our personality, our purpose, and yes, how compatible we are with other people. In the case of Geminis and Leos, these two signs might seem like an unexpected pairing, but they actually have a lot to offer each other. Here’s what to know about this matchup, from friendships to romance and more, from an astrologer.
Chatbots give positive, human-like responses to prompts from users.Credit: Jaap Arriens/NurPhoto via GettyAccounts of people developing psychosis — which renders them unable to distinguish between what is and is not reality — after interacting with generative artificial intelligence (AI) chatbots have increased in the past few months.Supportive? Addictive? Abusive? How AI companions affect our mental healthAt least 17 people have been reported to have developed psychosis, according to a preprint posted online last month1. After engaging with chatbots such as ChatGPT and Microsoft Copilot, some of these people experienced spiritual awakenings or uncovered what they thought were conspiracies. So far,…
Yet another reason to eat your veggies.
If you’re well versed in K-beauty terminology, perhaps you’ve come across the seven skin method. It practically exploded in popularity after its inception, and for good reason: The simple method results in dewy, luminous skin, in a way that makes people stop and wonder: Did she just wake up like that? It only makes sense why the technique holds its own among K-beauty mainstays like glass skin and the beloved BB cream.
Racism in NHS maternity care is an ongoing problem responsible for poorer outcomes among black women in England, an inquiry by MPs has concluded.Black women are more than twice as likely as white women to die in pregnancy, childbirth, or the postnatal period, the Health and Social Care Committee highlighted.The committee’s report, published on 17 September,1 found that black women in England continued to face disproportionately poor outcomes in maternity care owing to systemic failings in leadership, training, data collection, and accountability. MPs said that these failings had contributed to the NHS in England paying out £27.4bn in maternity negligence…
Credit: Stocktrek Images/Getty Images Canavan disease (CD) is a fatal genetic leukodystrophy caused by mutations in the ASPA gene, leading to accumulation of N-acetylaspartate (NAA) and breakdown of myelin, the insulating sheath around nerve fibers. Affected children suffer progressive neurological impairment, blindness, seizures, and early death.Until now, treatments have been supportive only. Previous gene therapy efforts targeted neurons but failed to substantially restore white matter or improve long-term outcomes. MYR-101 targets the cells that matter A Phase I/II trial (NCT04833907) of MYR-101—an investigational gene therapy using an engineered AAV vector (rAAV-Olig001) that selectively targets oligodendrocytes—is the first approach to aim…