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Cryo-electron microscopy structure of a viable bacteriophage designed by Evo. [Samuel King] DNA sequences contain the underlying instructions of life for all living organisms, but even the simplest microbial genomes are largely complex, with millions of DNA base pairs encoding the interplay of DNA, RNA, and proteins for cellular function at multiple scales, from individual pathways to whole genomes. “Most biological functions are not achieved by any single gene,” Brian Hie, PhD, assistant professor of chemical engineering at Stanford University and innovation investigator at Arc Institute, told GEN when describing the motivation behind building genome foundation models for generative design. “If…

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Generative approach trained on UK and Danish data estimates disease risk over time and hints at a new era for prevention. Imagine being able to map a person’s likely health trajectory twenty years into the future, not with certainty, but with probabilities calibrated across hundreds of possible conditions. That is the claim of a new generative AI model developed by EMBL, the German Cancer Research Centre (DKFZ) and the University of Copenhagen, which uses anonymized medical histories to estimate the timing and risk of more than 1,000 diseases. Trained on 400,000 participants from UK Biobank and tested on 1.9 million…

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UK law is currently failing people who are terminally ill and must be changed to give people autonomy and allow “dignity in their dying days,” the Labour MP Kim Leadbeater has said.Speaking to The BMJ, the MP for Spen Valley said that talking to people who were terminally ill and people whose loved ones had taken their own lives “out of desperation and fear” had shown her how bad the current situation was. She also spoke about concerns over the potential misuse of an assisted dying service that were raised in the first House of Lords debate last week.1While “very…

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Credit: JUAN GAERTNER/ Science Photo Library / Getty Images Researchers at the University of Cambridge, U.K., have developed a two-part “prodrug” system that can activate the immune system through the Stimulator of Interferon Genes (STING) pathway, allowing it to fight cancer without causing harm to healthy tissues. Published in the journal Nature Chemistry with the title “Tumor-specific STING agonist synthesis via a two-component prodrug system,” the research focuses on a specific pathway in our cells, called the STING pathway, that acts as an internal alarm system. It activates the human innate immune system when the body is attacked by pathogens,…

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The probiotic strain, marketed as Gyntima Balance outside the United States, improved the microbial balance, shifting from troublesome Community State Types associated with dysbiosis toward Lactobacillus-dominated vaginotypes.“This is a crucial distinction: The product doesn’t just alter the composition slightly, it promotes a complete change in the type of vaginal microbiota to one that is clinically recognized as healthy,” Dr. Marta Pérez, lead researcher and R&D manager at AB-Biotics, told NutraIngredients.“This result provides robust clinical evidence for the efficacy of a specifically selected oral probiotic for vaginal health. It validates the oral-gut-vagina axis by confirming that the probiotic can survive gastrointestinal…

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Reusable water bottles, especially plastic bottles or those with small parts, can breed bacteria. Bacteria may adhere better to plastic materials and multiply faster in certain environments.An expert recommends rinsing water bottles daily and doing a deeper clean every two to three days. If a reusable water bottle is your go-to for staying hydrated, you’re probably refilling it several times per day—at the gym, while running errands or between work calls. But how often do you actually stop to clean it? We asked a microbiologist and food safety expert about the ins and outs of washing your water bottle—you may need…

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Mechanical strain, such as that experienced while rubbing cream onto skin, makes skin more permeable, alters immune pathways, and opens possibilities for non-invasive drug delivery.Image credit:©iStock, RidofranzAs the outermost layer of the body, the skin is under a constant barrage of stimuli, ranging from the benign application of sunscreen to harmful puncture wounds. Sustained mechanical stress due to injury or inflammation triggers the immune defense of the skin.1 In the case of skin stretching, cell adhesion molecules in the epidermis sense this stimulus, leading to cell proliferation, secretion of growth factors, and production of inflammatory modulators.2 For instance, continuous skin…

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Sues, H.-D. Functional morphology of the dome in pachycephalosaurid dinosaurs. N. Jb. Geol. Palaontol. Mh. 8, 459–472 (1978). Google Scholar  Snively, E. & Theodor, J. M. Common functional correlates of head-strike behavior in the pachycephalosaur Stegoceras validum (Ornithischia, Dinosauria) and combative artiodactyls. PLoS ONE 6, e21422 (2011).Article  ADS  CAS  PubMed  PubMed Central  Google Scholar  Peterson, J. E., Dischler, C. & Longrich, N. R. Distributions of cranial pathologies provide evidence for head-butting in dome-headed dinosaurs (Pachycephalosauridae). PLoS ONE 8, e68620 (2013).Article  ADS  CAS  PubMed  PubMed Central  Google Scholar  Evans, D. C., Schott, R. K., Larson, D. W., Brown, C. M. &…

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Functional probiotic pioneer, BioGrowing is spotlighting targeted biotic innovations like its Flora-Focus strains to aid in Helicobacter pylori infections and support the vaginal microbiome, immune health, and weight management.Nutrition Insight sits down with Yuan Feng, Ph.D., an academic scientist at BioGrowing, to discuss the company’s current offerings, future R&D, and how its offerings speak to emerging global trends and consumer demand for natural health solutions.The company is showcasing its probiotic solutions at Vitafoods Asia 2025 (September 17–19) in Bangkok, Thailand, at Hall 7, stand# R36.Can you tell us about some of BioGrowing’s flagship strains and solutions?Feng: I would like to introduce…

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