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Scientists from Croatia have identified 90 genes associated with the glycosylation of immunoglobulin (IgG). The team, who has already shown that 20 of these genes can be used to tweak glycosylation pathways, hopes the work will help drug developers improve yields and streamline the scale-up of antibody production processes. “Glycosylation is a Critical Quality Attribute (CQA) that can shift [a lot] during scale-up,” explains Anika Mijakovac, PhD, a researcher from the University of Zagreb. “Using a production cell line with integrated CRISPR tools, you can [potentially] shift the pattern back quickly.” According to Mijakovac, the team began trying to identify…

The No. 1 frozen food recommended for purchase at Costco is Bibigo’s Steamed Dumplings with various flavorful fillings.The dumplings are a convenient meal option as they cook in just 2 minutes in the microwave. They are highly recommended for busy days or when you don’t feel like cooking. Costco’s freezer aisles are jam-packed with nutritious and tasty finds, from frozen fruit to RD-approved entrees and sides. Keeping a fully stocked freezer comes in handy when I need a quick, filling meal, so I often turn to Costco to help me fill my freezer’s shelves. The convenience of a ready-made frozen food…

Mouse studiesWild-type C57BL/6 male mice (6–8 weeks of age) were purchased from BIKAI. Nlrx1−/− mice were purchased from Cyagen. NSG mice were purchased from Shanghai Model Organisms Center. All mice were housed in the specific-pathogen-free animal facility of Fudan University with the following environmental parameters: temperature maintained at 21–25 °C, relative humidity at 45–65% and a 12 h–12 h light–dark cycle.All mice were randomly separated into each experiment group. Mice were fasted from 10:00 for 24 h with free access to water without food. PBS or HC (59847, Sigma-Aldrich; 100 mg per kg) was intraperitoneally injected into mice at 10:00 for 4 h. For acetate administration, mice were…

Studying the complex interactions of genetic and epigenetic factors will help researchers like Maja Jagodic better understand multiple sclerosis progression.Image credit:©iStock, koto_fejaWhile multiple sclerosis (MS) relapses are manageable with immune-modulatory treatments, the mechanisms behind the progressive stage of this disease are poorly understood. Karolinska Institute molecular biologist Maja Jagodic is drawn to the challenge of untangling the genetic and epigenetic layers driving this chronic disorder. Recently, she embarked on a project to better understand the neurodegenerative processes behind MS and identify biomarkers of disease activity and progression based on DNA methylation. Using biomodal’s duet multiomics solution that combines genetic and epigenetic…

Credit: KATERYNA KON/SCIENCE PHOTO LIBRARY/Getty Images An urgently needed test for the most common form of liver cancer may soon be available. Liver cancer can be diagnosed without a biopsy, but the current test, which is ultrasound (US), has only 22% sensitivity. The rate of this type of cancer is becoming more prevalent worldwide. Regular screening is recommended for people with risk factors like cirrhosis, chronic hepatitis B infection, or a family history of liver cancer. Early diagnosis is a key factor in survival. Exact Sciences’ multiomic Oncoguard Liver blood test has several times the sensitivity of US and appears…

The best way to bathe or shower for psoriasis can vary based on individual factors and preferences, but there are some general principles to keep in mind.Resist the temptation to warm up with a long bath or shower. “We know that long, hot showers can lead to dry skin and, by extension, a compromised skin barrier,” says Kimberly Katz, MD, a dermatologist at UW Medicine in Seattle. “Dry skin can worsen the sensation of itch and irritation.”Typically, “The goal is to limit showers to about 5 minutes and baths to 15 minutes or less” to avoid skin drying or irritation,…

Binance’s venture arm backs Renewal Bio’s mission to harness stem cells’ innate potential to redefine repair and renewal of human biology. Crypto-backed venture capital giant YZi Labs has made its first investment in biotechnology, backing Renewal Bio, a regenerative medicine company developing “DNA-identical” human cells and tissues known as stembroids. The undisclosed amount of funding will be used to accelerate Renewal Bio’s pre-clinical work on hematopoietic (blood) stem cells and broaden its research into liver, heart, and pancreatic applications. Previously known as Binance Labs, YZi Labs manages more than $10 billion in assets across over 300 projects worldwide. Founded in…

What happened after publicationIn this paper by Attar and colleagues (BMJ 2025;391:e083382, doi:10.1136/bmj-2024-083382, published 29 October 2025), The BMJ was alerted to post-publication discussion raising concerns about a variety of issues; some issues were apparent from the data that support the paper, and are linked to from the article. Examples of the issues identified include irregularities in the data, concern about the inclusion of participants who did not meet the age criteria specified in the study, and concerns about undeclared conflicts of interest and authorship.Reason for expressing concernThe editors judge that the trial may have breached accepted practices and that…

When you’re trying to lose weight, it’s easy to focus on what you can’t eat.But there are easy expert-backed swaps that can help you lose weight without sacrificing taste.Try swapping in roasted chickpeas, chocolate almonds, protein coffee and high-fiber wraps. Despite the buzz on TikTok and Instagram, you don’t have to be on a restrictive diet to lose weight. In fact, studies show that extreme calorie cutting and yo-yo dieting can lead to weight gain and increased body fat over time., The secret to sustainable weight loss? Focusing on foods that are high in protein, fiber and healthy fats. These…

University reputations and finances often hinge on their position in global ranking tables. Students use rankings to quickly identify the best place to study — or, at least, what might be perceived to be the best by any future employer. Even a small shift in rank can affect how many students apply to a university, altering the income from tuition fees (R.-D. Baltaru et al. Stud. High. Educ. 47, 2323–2335; 2022).The future of universitiesAnd governments love the simplicity of rankings. Many will fund their citizens’ overseas study only at institutions that are high up the listings. National investment initiatives —…