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ATP bioluminescence assays reveal microbial contamination in laboratory samples, enabling more rapid and sensitive quality control testing than traditional culture-based methods.©iStock, rsporeaResearchers and therapeutic manufacturers have long relied on classical microbiological methods to check their samples and surfaces for microbial contamination, primarily using lengthy culture-dependent approaches.1 Such quality control (QC) testing is essential, but despite their widespread use and regulatory acceptance, traditional methods pose challenges in the modern laboratory, where rapid results and objective measurements are needed to strengthen scalable workflows. Scientists and regulatory experts increasingly turn to luminometry to automate and accelerate QC via ATP bioluminescence assays.The Trouble with…

Discussions on longevity say future of aging isn’t about fat loss but about calming inflammation, restoring energy and protecting metabolism. Longevity used to be tied to wrinkle creams, detox teas and vague promises of “antiaging.” But on a recent episode of the Come Together podcast, host Abe Lichy sits down with Dr Amanda Kahn, board-certified internist and longevity specialist, who’s pushing the conversation into far more serious, biological territory. Instead of treating aging as something that shows up on your face, she frames it as something that begins at the cellular level. In her view, modern life chips away at…

Bioprocessing technologies need to be able to speak to each other more effectively, according to U.S. National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL) researchers, who say drug firms will only reap the full benefits of digitization when information can flow between unit operations. In “digital manufacturing,” data collected at each unit operation, inform and control subsequent stages of the process. The critical factor is “interoperability,” which is the ability to transfer this information from one step to the next in a usable form. And interoperability is where biopharmaceutical companies often struggle, according to Roger Hart, PhD, big data program…

Credit: Md Saiful Islam Khan / iStock / Getty Images Plus Researchers at the University of Pennsylvania have discovered that delayed side effects such as neurotoxicity and intestinal inflammation that can appear weeks or months after B-cell maturation antigen–directed (BCMA) CAR T cell therapy for multiple myeloma have a common root cause and correlate to high rates of death unrelated to cancer relapse, primarily infections. These findings, presented recently at the American Society of Hematology Annual Meeting in two separate abstracts (14221, 12231), detail how these side effects, called CAR T–associated immune-related adverse events (CirAE), arise after therapy and may…

This postdoc explores chemical systems that could power future materials and technologies.Image credit:©iStock.com, BlackJack3DQ | Write a brief introduction to yourself including the lab you work in and your research background. My name is Francisco Martins, a physical organic chemist in the Wu Lab at the University of Houston. I investigate molecules for solar energy storage and novel chemical reactions. My research aims to optimize molecular properties for applications in materials science, pharmaceuticals, and agrochemicals, bridging fundamental chemistry with practical innovation.Q | How did you first get interested in science and/or your field of research? It might sound cliché, but…

Subsense secures additional $10m following progress towards nanoparticle-based approach to neural interface control. Neurotech startup Subsense has expanded its total financing to $27 million as it accelerates its non-surgical approach to brain–computer interfaces built around nanoparticles rather than implanted electrodes. Following an initial $17 million seed round earlier this year, the company today closed an additional $10 million from Golden Falcon Capital after reporting early progress in materials development, nanoparticle stimulation and neural signal detection. The BCI market continues to accelerate apace, with significant investments secured by a host of companies working on a variety of approaches and attracting the…

Surprising DNA (deoxyribonucleic acid) results, conceptual image. Origami model of a DNA molecule popping out of a gift box. If you haven’t tackled your holiday shopping yet, it’s time to put down the stethoscopes and step away from the spectrometers. Even if you don’t personally celebrate a December holiday, chances are your workplace or friend group has a gift exchange with your name on it. So whether you’re racing to a white-elephant swap, prepping for Secret Santa, heading out on a family getaway, or simply shutting down and hunkering in, bring a dose of precision medicine to the people you…

A new automated process for engineering tumor-targeting T cells could help accelerate personalized cancer treatments—while easing the physical toll on patients. Richard C. Koya, MD, PhD, who directs cGMP vector development and production at the University of Chicago Comprehensive Cancer Center, and his colleagues developed a streamlined system that drastically reduces the labor, time, and massive quantities of cells normally required to produce T-cell receptor-engineered T cells (TCR-T), a highly promising form of immunotherapy. “Automating the activation, transduction, and expansion of TCR-T cells is a game-changer,” says Koya. The system he and his colleagues developed uses a closed “plug-and-play” hollow-fiber…

As winter wraps the world in its frosty embrace, respiratory syncytial virus (RSV) infection leaves many babies coughing and wheezing. RSV infects nearly 90 percent of children before they turn two years old, shaping their health long after the sniffles have faded.1 “There’s a very strong link in epidemiology between early-life RSV infection and the probability of developing allergy and asthma later in life,” said Hamida Hammad, an immunology and inflammation researcher at the Flemish Institute for Biotechnology (VIB) and Ghent University. In addition to RSV, parental allergies also predispose kids to allergic asthma.2 To better understand how RSV and…

Sir Jonathan Symonds on healthspan, prevention and why data and analytical tools are now the most critical components in biology. Hevolution Foundation recently released the second edition of its Global Healthspan Report, examining the state of healthspan science, technology, investments and policy globally. Building on two global surveys, investment data from Longevity.Technology, expert interviews and extensive research, the 2025 edition of the report examines the current state and future prospects of healthspan, highlighting key developments and actions the field can take as an ecosystem to bring healthspan to the next level. Longevity.Technology: Among the key opinion leaders contributing to the Global…