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Credit: Northwestern University Researchers at Northwestern University have developed a new test for the diagnosis of hepatitis C virus (HCV) infections that can return results 75% faster than rapid HCV tests available today. In a study published in The Journal of Infectious Diseases, the new 15-minute test showed 100% agreement with the results of commercial platforms currently in use to diagnose hepatitis C. “We were able to develop a diagnostic test that can be performed at the point of care during a patient’s clinical visit, which could enable same-day diagnosis and treatment in support of HCV elimination efforts,” said Sally…

Inductive Bio, an AI drug discovery partner developing virtual chemistry labs, received an up to $21M award to lead a project to develop next-generation models of drug toxicity to advance safer therapeutics and reduce reliance on animal testing. The company has teamed up with Amgen, Cincinnati Children’s Hospital Medical Center, Baylor College of Medicine, and Torch Bio, a University of Michigan Medical School spinout company, to use AI trained on data from advanced human model systems to build toxicity prediction models that could fundamentally change how drug safety is assessed. This approach has the potential to reduce late-stage development failures…

Protecting freshwater fish biodiversity in the Amazon is a top goal for conservation scientists. Genomic sequencing is redefining these efforts for the Amazonian carnivorous pirarucu fish.©iStock, Pham HungProtecting Amazonian BiodiversityThe Amazon River basin is larger than any other on the planet, covering an expanse of over six million square kilometres and is home to a vast abundance and variety of freshwater fish species.1 While many of these species remain unidentified, this biodiversity serves important ecological and economic roles. Amazonian fish biodiversity is sensitive to human influence, including deforestation, pollution, tributary dam construction, overfishing, and climate change.1 As such, there is…

In Aging Cell, researchers have described how an age-related deficiency in another compound leads the antioxidant FoxO1 to contribute to bone deterioration in osteoporosis by siphoning from a bone-building pathway. A harmful antioxidant? Because they fight against harmful reactive oxygen species (ROS), antioxidants, both external and internal, are normally viewed as having positive effects against aging. This includes bone tissue, as previous work has found that knocking out FoxO1 harms bone formation while inducing its overexpression leads to more bone building [1]. On the other hand, another team of researchers has found that knocking out FoxO1 in osteoblasts, the cells…

Credit: Svisio / iStock / Getty Images Plus Californian researchers believe they have found a new way to reveal the biological mechanisms that link genes to human traits and diseases. The tool, outlined in Nature, may help in understanding the genetic basis of complex traits that have so far eluded genome-wide association studies (GWAS). The approach blends estimates of gene-trait relationships from loss-of-function (LoF) burden tests with advances in genome editing and high throughput single-cell RNA sequencing represented by the Perturb-seq method. This creates a graph that reveals both trait-relevant pathways and also the functions of genes and programs to…

As momentum builds, London’s 2026 global event announces leading voices shaping the worldwide future of healthspan. The Longevity Show has released its first slate of speakers, offering an early glimpse of the depth and breadth of expertise set to converge in London next June. Designed as a meeting point for geroscientists, clinicians, technologists and the increasingly longevity-literate public, the Show aims to bridge cutting-edge research with practical tools for healthier, longer lives. With anticipation building around this inaugural event, the initial speaker announcement signals a program that is as diverse as it is ambitious, spanning biological age clocks, precision diagnostics,…

Awesome Health Podcast – episode 295 Are you constantly battling fatigue, brain fog, and persistent bloating? You might be dealing with a silent instigator: LPS endotoxins. We recently dove deep into this topic with Martha Carlin, a pioneering microbiome researcher and founder of The BioCollective. Here’s what you need to know about this stealthy driver of chronic inflammation. In this podcast, you’ll learn: What is LPS and how does it silently drive fatigue, bloating, and brain fog? What your poop can tell you about your hormones, brain, and immune system Red flags hiding in your daily routine—and how to shift…

Credit: Nemes Laszlo/Science Photo Library/Getty Images Researchers at the Keck School of Medicine of University of Southern California (USC) have developed a new type of chimeric antigen receptor (CAR) T cell that elicits a more controlled immune response to cancer in mice. Using a technology called Synthetic TCR signaling for Enhancing Memory T cells (STEM), the team created CARs with a ZAP70-derived signaling domain (ZAP327) that showed enhanced therapeutic antitumor activity and increased in vivo T cell persistence. The researchers’ preclinical study, including tests in mouse models, demonstrated that the new CAR constructs effectively kill cancer cells, including those that…

Researchers have traditionally employed histopathology techniques, which involve the microscopic examination of tissue, to gain insight into disease processes. This approach often leads to subjective interpretations and requires labor-intensive analysis. Computational pathology uses advanced algorithms and digital imaging to extract quantitative data from tissue samples, addressing some of these limitations. However, integrating these tools into clinical workflows remains a complex task. Recent advances in artificial intelligence (AI) foundation models have rapidly transformed the diagnostic landscape, particularly by integrating multiple data sources, enabling faster and more accurate biomarker identification from complex imaging datasets. Paul O’Reilly, PhDHead of InnovationSonrai AnalyticsIn this Innovation…

Happy holidays! Winter is in full swing for those of us in the Northern Hemisphere. It is a time for cozy nights by the fire and a great time to catch up on what has been happening at Lifespan News and LRI. A cultural intelligence platform for effective advocacy We are delighted to announce that the campaign to develop a cultural intelligence platform has been a success! Thanks to donations from the community and Longevity Alliance members, the project will now start. The goal of the campaign was $100,000, and we managed to raise $104,395, taking us to 104% needed…