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Credit: selvanegra/ Getty Images Research led by National Cheng Kung University, Taiwan, suggests glucagon-like peptide 1 (GLP-1) receptor agonists can protect against spine fracture risk. “Type 2 diabetes is a well-established risk factor for vertebral fractures associated with long-term disability and increased mortality,” explain Yu Chang, MD, a researcher and clinician at National Cheng Kung University, and colleagues in JAMA Surgery. “While GLP-1 receptor agonists have demonstrated therapeutic benefits beyond glycemic control, their role in bone health remains uncertain, and evidence regarding their association with vertebral fracture risk has been inconsistent.” Chang and colleagues carried out a study using electronic…

For decades, the words “dessert” and “fitness” were viewed as mortal enemies. If you wanted to build muscle or lose weight, the prevailing wisdom was that you had to say goodbye to brownies, ice cream, and cheesecake. The best you could hope for was a sad, dry rice cake or a plain apple. But the nutritional landscape has shifted. We are now in the golden age of high protein desserts. Whether you are a bodybuilder looking to hit macros, a diabetic managing blood sugar, or simply someone trying to shed a few pounds without misery, the evolution of food science…

Pow.Bio, which specializes in AI-enabled continuous fermentation technology, and the Bühler Group, are teaming up to bring an integrated continuous precision fermentation platform to market. Officials at Bühler and Pow.Bio, who say the collaboration advances industrial biomanufacturing by accelerating process development, reducing unit production costs as the result of a continuous process, and improving operational performance, add that they are now ready to begin onboarding customers. Unlike traditional fermentation approaches that rely on batch or fed-batch processes (stop-and-start methods that require the tank to be emptied and cleaned between runs), the companies now offer a streamlined solution, maintains Shannon Hall,…

Credit: quantic69 / iStock / Getty Images Plus For more than two decades, Timothy Lu, MD, PhD, has been dedicated to a problem that has vexed cell therapy since its inception: how to make engineered cells “smart” enough to distinguish cancer from healthy tissue. In the CAR T era, many of the most transformational therapies have targeted a handful of “clean” antigens—molecules expressed on tumor cells but rarely found on healthy ones. But most cancers don’t present such tidy molecular bull’s-eyes. When healthy tissues share the same markers, CAR T cells can destroy not only tumors but also the cells…

Tuna salad is one of those culinary paradoxes. On one hand, it is a staple of bodybuilders and health enthusiasts looking for a lean protein punch. On the other hand, it is a comfort food often laden with heavy mayonnaise and served on processed white bread, leading many to question its nutritional value. So, is tuna salad healthy? The answer is a resounding yes—but with conditions. Because “tuna salad” can range from a 200-calorie, nutrient-dense bowl to an 800-calorie fat bomb, understanding the ingredients is key.  This guide will dismantle the confusion surrounding tuna, mayonnaise, mercury safety, and weight loss,…

Primary immune thrombocytopenia (ITP) is an autoimmune condition where the body’s immune cells mistakenly attack platelets, the blood cells responsible for clotting, which can lead to life-threatening bleeding. Associated with abnormal bleeding from skin and mucous membranes, this condition affects around 50,000 people in the United States, can be diagnosed at any age, and contributes to other symptoms like easy bruising and fatigue. In a Phase III clinical trial, over half of patients who received a limited course of an experimental monoclonal antibody known as ianalumab were able to sustain safe platelet counts for at least one year without any…

At the turn of the century, the biomedical research community saw a landmark global effort, when scientists built a reference human genome sequence to better understand the genes underlying health and disease. However, they stitched together this reference genome sequence from individual genomes of people belonging to a small slice of humanity. “Most of the omics data, including transcriptomic data, is dominated by samples that have been obtained from individuals of European ancestry,” said Roderic Guigó, a computational genomics researcher at Barcelona Institute of Science and Technology. To bridge this gap, he teamed up with Marta Melé, a transcriptomics and…

On a recent press trip to Oxford, Gustav Ceder visited John Todd, PhD, at the Centre for Human Genetics to discuss his latest research and reflect on the path that brought him there. Ceder having followed Todd’s work for years, has always been fascinated by the way Todd pairs early adoption of new technologies with a clear translational purpose, and maintains a sustained focus on the type 1 diabetes community and more recently, on the field of neuroinflammation. Q: We’re speaking today at the Wellcome Centre–what has this place meant to you personally and briefly, what influence has this center…

Doctors and researchers try to understand what medications a person has taken by asking patients directly or by looking at medical records. But this information is often incomplete. People may forget what they took, use over-the-counter drugs, take leftover prescription drugs, buy medicines online, or might be exposed unintentionally through food and the environment. As a result, significant drug exposures can be missed. Knowing what drugs an individual has been exposed to is important because they can have unexpected effects on biology and health. A team of researchers from the University of California (UC), San Diego, and their colleagues has now…

Credit: Vertigo3d / iStock / Getty Images Plus Precision mental health innovations that harness artificial intelligence (AI), data, smartphones, and wearable devices capable of real-time measurement can detect, diagnose, treat, and care for individuals with mental health conditions more effectively than ever before. These technologies have the potential to address a burgeoning global mental health crisis that current human resources cannot solve. Thomas Insel, MD, is a psychiatrist and neuroscientist, consulting professor at Stanford University, previous head of the National Institute of Mental Health, active founder or partner in multiple mental health technology startups, and author of Healing: Our Path…