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Credit: Vertigo3d / iStock / Getty Images Plus Precision mental health innovations that harness artificial intelligence (AI), data, smartphones, and wearable devices capable of real-time measurement can detect, diagnose, treat, and care for individuals with mental health conditions more effectively than ever before. These technologies have the potential to address a burgeoning global mental health crisis that current human resources cannot solve. Thomas Insel, MD, is a psychiatrist and neuroscientist, consulting professor at Stanford University, previous head of the National Institute of Mental Health, active founder or partner in multiple mental health technology startups, and author of Healing: Our Path…

Researchers found that young female students with anxiety and insomnia symptoms had lower levels of natural killer cells, which may negatively affect the immune response.Image credit:©iStock.com, PonyWangMany people are familiar with anxiety, whether it shows up as jittery nerves, a pounding heartbeat, or difficulty sleeping. But for those with generalized anxiety disorder, these feelings can linger and disrupt daily life. When anxiety and insomnia are both present, the effects can extend beyond mental well-being and influence physical health as well.This motivated Renad Alhamawi, an immunologist at Taibah University, to explore how anxiety and insomnia might interact with the immune system.…

Credit: FatCamera / Getty Images A first-in-class clinical trial has supported the feasibility of using “ready-made” CAR T cells to fight T-cell acute lymphoblastic leukemia (ALL). The Phase I study is a step towards using this form of immunotherapy to move patients into remission if leukemia has returned or not responded following chemotherapy, so they can receive a bone marrow transplant. The findings are reported in the New England Journal of Medicine and are also being presented this week at the American Society of Hematology annual meeting in Orlando, Florida. These ‘ready-made’ CAR T cells are produced by base editing donor…

Could a future exist where the brain and artificial intelligence systems communicate as effortlessly as a smartphone connecting to Wi-Fi? This may sound like science fiction, but researchers are taking steps toward that reality. A team from Columbia University, New York Presbyterian Hospital, Stanford University, and the University of Pennsylvania has developed a brain–computer interface (BCI) called the Biological Interface System to Cortex (BISC), described in Nature Electronics in a paper titled, “A wireless subdural-contained brain–computer interface with 65,536 electrodes and 1,024 channels.” The device promises ultra-high resolution neural recording and wireless operation in a very small form compared to…

Credit: KTSDESIGN/SCIENCE PHOTO LIBRARY/Getty Images Researchers at Korea University College of Medicine have developed a liquid biopsy method that can detect cancer mutations present in very low frequencies from all cell-free DNA in a typical blood sample. The ultrasensitive method, called MUTE-Seq, uses FnCas9-AF2, an engineered high-fidelity CRISPR enzyme that depletes wild-type DNA in the sample before sequencing allowing for circulating tumor DNA (ctDNA) detection below 0.1% of total cfDNA, exceeding current detection limits. Details of this new approach are published in the journal Advanced Materials. “Our findings suggest that the MUTE-Seq method has considerable potential for developing diagnosis panels…

NeurIPS 2025 hosted at the San Diego Convention Center [Fay Lin] San Diego – More than 24,000 machine learning experts gathered for the largest Neural Information Processing Systems (NeurIPS) conference to date, hosted against the sunny December backdrop of the San Diego Convention Center. NeurIPS 2025 featured over 5,000 papers accepted from a whopping pool of more than 21,000 submissions.    Among the crowd was a growing life sciences community that attests biology is reaching a transformer moment, mirroring the 2017 publication of “Attention is All You Need,” which paved the way for modern AI architectures, including today’s large language models.   Evan Feinberg, PhD, CEO of Genesis Therapeutics, has watched NeurIPS evolve over recent…

In a new study, extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) improved spatial working memory in rhesus macaques, suggesting a possible reversal of age-related cognitive decline [1]. The “normal” decline Even “healthy” aging (not accompanied by obvious age-related diseases such as dementia) leads to cognitive impairments, particularly in working memory, executive function, and recognition memory [2]. This incessant cognitive decline, which starts at midlife, is linked to myelin pathology in the brain, rather than widespread neuronal loss [3]. In this new study published in the journal GeroScience, researchers at Boston University Chobanian & Avedisian School of Medicine tested…

Weight loss control planning. White scale and measuring tape for body dieting healthy life. Green background. Top view copy space for banner Drug developers have long pursued the elusive goal of safely increasing energy expenditure to treat metabolic conditions and obesity. Leiden-based Cantoni Therapeutics is hoping to achieve this goal with its novel small molecule inhibitors of nicotinamide N-methyltransferase (NNMT), which have the potential to treat obesity and improve metabolism without loss of muscle mass. The promise of the technology and pathway is something that attracted Annegret Van der Aa, PhD, to take up the role of CEO and executive…

A 3D virtual model of the PKMYT1–PROTAC–CRBN ternary complex depicting how Insilico Medicine’s bifunctional proteolysis-targeting chimera (PROTAC) D16-M1P2 (shown in yellow) inhibits membrane-associated tyrosine-threonine protein kinase 1 (PKMYT1, shown in green), tagging the incapacitated enzyme to ubiquitin E3 ligase cereblon (CRBN, shown in blue), the protein system for targeted cell waste removal. A team of researchers at Insilico Medicine has used the company’s Chemistry42 generative artificial intelligence (AI) platform to design a first-in-class PROTAC designed to fight cancer by degrading and inhibiting PKMYT1, leading to its destruction. [Insilico Medicine] Because of its pivotal role in cell cycle regulation—and its overexpression…

To cut a dragon fruit properly, follow these simple steps: Slice: Place the fruit on a cutting board and cut it in half lengthwise using a sharp knife. Scoop: Run a tablespoon between the pink skin and the flesh to scoop the meat out in one piece. Alternatively, peel the skin back with your fingers. Cube: Discard the inedible skin and chop the flesh into cubes or wedges. Serve chilled. Dragon fruit, also known as pitaya, is arguably the most photogenic fruit in the produce aisle. With its vibrant, bright pink skin, green scales, and speckled flesh, it looks like…