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An international research team has uncovered a mechanism that protects nerve cells from a form of premature cell death known as ferroptosis. Headed by Prof. Marcus Conrad, PhD, director of the Institute of Metabolism and Cell Death at Helmholtz Munich, the scientists’ in vitro experiments and in vivo work in mice link a genetic mutation in the enzyme GPX4 with ferroptotic neurodegeneration and Alzheimer’s-like signatures in mouse models. The team suggests the study provides the first molecular evidence that ferroptosis can drive neurodegeneration in the brain, and could point to new therapeutic strategies for neurodegenerative diseases, particularly for severe early-onset…

Credit: Salah Uddin/ iStock / Getty Images Plus At the 67th American Society of Hematology (ASH) Annual Meeting, researchers from The University of Texas MD Anderson Cancer Center presented new clinical data positioning pivekimab sunirine (PVEK), a CD123-targeting antibody-drug conjugate, as a potential addition to treatment strategies for two aggressive and historically hard-to-treat malignancies: acute myeloid leukemia (AML) and blastic plasmacytoid dendritic cell neoplasm (BPDCN). Unlike many antibodies that rely solely on immune engagement, PVEK delivers a DNA-damaging payload directly into CD123-expressing cells, a design intended to support activity even in chemoresistant disease. A targeted strategy for CD123-positive leukemias The…

Target deconvolution, particularly when paired with proteomics techniques, plays a crucial role in drug screening, covalent drug discovery, mechanism of action (MOA) discovery, and target identification. By using chemical proteomics, researchers can more precisely identify interactions between small molecules and cellular targets, aiding in the development of new therapeutic candidates.In this GEN webinar, our expert speakers will explore cutting-edge drug discovery techniques for target deconvolution and multiplex target discovery. They will also delve into how multiplex target discovery and target tractability assessment accelerate the drug discovery process. Attendees will learn how to apply target discovery and target deconvolution technologies in…

Credit: Huntstock/ Getty Images Dyne Therapeutics’ Duchenne muscular dystrophy (DMD) therapy z-rostudirsen significantly improved dystrophin level and function versus placebo in boys aged four to 16 years with the condition who were eligible for exon 51 skipping therapy. The results showed an increase in dystrophin levels to 5.46% at six months after adjusting for muscle content. This amounted to an approximate seven-fold change from baseline, which was around the same increase seen in earlier trials of z-rostudirsen. DMD is a rare, progressive neuromuscular disorder caused by a range of different mutations in the DMD gene found on the X chromosome…

Researchers have discovered that extracellular vesicles (EVs) derived from the nasal mucosa provide significant regenerative benefits to tissues throughout the body, including the brain. A very regenerative tissue Previous work involving the transection of sizable portions of the nasal mucosa has found that this tissue grows back quickly and without scarring, even in older people [1], signifying that the tissue has intrinsic regenerative properties that persist despite aging. These researchers hypothesized that extracellular vesicles (EVs), which cells use to send proteins, RNA, and DNA to one another [2] and are a common subject of aging research, may be a key…

View eBook With the MiSeq™ i100 Series, Illumina continues to set the highest standards. Advancements in system design, sequencing chemistry, and data analysis deliver the simplest, fastest benchtop sequencing and proven accuracy. The MiSeq i100 Series is accessible to users of all levels and simplifies the NGS workflow— from library preparation to data analysis. With same-day results for various applications, including small whole-genome sequencing (WGS), targeted gene sequencing, and gene expression analysis, the MiSeq i100 Series enables labs to address complex genomics questions in infectious disease, microbiology, oncology, and beyond. The MiSeq i100 and MiSeq i100 Plus Systems are designed…

The time of day when a patient receives cancer immunotherapy could likely impact their outcomes—a new study suggests that treatment before 3PM is more beneficial. Image credit:©iStock.com, SergeyChaykoMounting evidence suggests that the time of day at which cancer patients receive treatment could impact their outcomes. This effect is likely due to the circadian rhythm-dependent fluctuations in the function of immune cells as well as proteins that regulate their function, also called checkpoints. In line with this, in a recent meta-analysis, researchers found that patients with various types of advanced cancer who underwent immune checkpoint inhibitor (ICI) infusions earlier in the day…

Credit: KATERYNA KON/SCIENCE PHOTO LIBRARY/Getty Images A different formulation of Novartis’s gene therapy Zolgensma (onasemnogene abeparvovec), known as Itvisma, achieved good results in a Phase III trial in spinal muscular atrophy (SMA) patients aged 2-17 years. While the improvements in mobility are smaller than those seen in younger children treated with Zolgensma, they are still enough to give these children significant improvements in their daily life. SMA is a rare inherited disease in which a fault in both copies of the SMN1 gene means the body cannot make enough of the protein encoded by this gene, which is needed for…

We have all been there: You buy a large, vibrant bunch of celery for a single recipe—perhaps a pot of chicken noodle soup or a Thanksgiving stuffing—and you use exactly three stalks. The rest goes back into the crisper drawer, where it sits, forgotten, until you discover it two weeks later, limp, rubbery, and sad. This is a common kitchen tragedy, but it begs the question: Can you freeze celery to save it from the trash bin? The short answer is yes, absolutely. Freezing celery is one of the most effective ways to reduce food waste and ensure you always…

Trimethylamine (TMA), a molecule produced from dietary choline by gut bacteria, has been shown to block a key immune pathway and improve blood sugar control. This microbial molecule may provide a surprising boost in the fight against insulin resistance and type 2 diabetes. “This shows how nutrition and our gut microbes can work together by producing molecules that fight inflammation and improve metabolic health,” said Patrice Cani, PhD, professor of Physiology, Metabolism and Nutrition at the Louvain Drug Research Institute (LDRI) of the University of Louvain, Belgium and visiting professor at Imperial College London. This work appears in Nature Metabolism…