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You have full access to this article via your institution. Nature’s modelling shows that previously awarded NIH grants that could be at risk today include funding for a project investigating whether computed-tomography scans improve detection of lung cancer. Credit: K H Fung/Science Photo LibraryIn 2011, researchers discovered that, compared with radiography (X-rays), computed tomography (CT) scans improved detection of lung cancer, reducing deaths by one-fifth (The National Lung Screening Trial Research Team N. Engl. J. Med. 365, 395–409; 2011).Their study, which has been cited almost 10,000 times, was made possible by a US$57-million National Institutes of Health (NIH) grant that…

Credit: Juan Gaertner/ Science Photo Library/ Getty Images Researchers at the University of Bristol’s Integrative Cancer Epidemiology Program (ICEP) have presented new evidence that how fat is distributed in people’s bodies, not just obesity, could make a difference to their risk of developing certain cancers. The study, published in the Journal of the National Cancer Institute, found that the accumulation of certain body fats—such as visceral fat and liver fat—affects the risk of 12 obesity-related cancers, independent of BMI. “These findings support the growing consensus that BMI, while useful for population-level trends, may be too simplistic for assessing individual health…

If the 264 million students enrolled in higher education around the globe were a country, it would be the fifth most populous in the world. Some 53% of its citizens would identify as women and most would be located in Asia. Residents would speak and study in hundreds of languages, but English would dominate.The future of universitiesThis nation of learners would also be one of the fastest growing. Since 2000, the number of university students around the world has more than doubled, and the number that cross borders to learn has roughly tripled, to almost seven million. Aided by the…

AI-designed ‘companion therapeutic’ works alongside GLP-1 therapy through a complementary mechanism linked to healthy aging. Hot on the heels of multiple references to GLP-1 receptor agonists as longevity drugs at the recent Aging Research and Drug Discovery meeting in Copenhagen, AI-powered biotech MindWalk revealed it is moving forward with a new approach to GLP-1s that extends beyond diabetes and obesity into longevity therapeutics. The Austin-based company, formerly known as ImmunoPrecise Antibodies, announced the development of a dual-pathway regimen that pairs its AI-designed GLP-1 analogs with a proprietary companion therapeutic, designed to work through a separate but complementary biological mechanism linked…

Taking a daily low-dose aspirin pill can significantly reduce the risk of colorectal cancer returning in people with specific genetic mutations, a new study suggests.The study followed nearly 3,000 colorectal cancer survivors in Sweden. About one-third had tumors with a specific genetic mutation in what’s called the PIK3 pathway. Researchers randomly assigned participants to take a 160 milligram daily aspirin pill or a placebo for three years after surgery to remove their tumors.Participants with this genetic mutation who took daily aspirin were roughly half as likely to experience cancer recurrence by the end of the study period compared with those…

Scientists from Mass General Brigham and the Broad Institute of MIT and Harvard have used CRISPR screens to identify genetic modifications that influence T cell function and survival in cultures and preclinical models of multiple myeloma. Their findings could be used to make chimeric antigen receptor T cell (CAR T) therapies more effective. Full details are provided in a new Nature paper titled “In vivo CRISPR screens identify modifiers of CAR-T cell function in myeloma.” As the study’s co-senior author, Robert Manguso, PhD, a principal investigator in the Massachusetts General Hospital Cancer Center and director of the Tumor Immunotherapy Discovery…

Eating a heart-healthy diet is easier than ever, thanks to these tasty dishes. These dinner recipes are lower in saturated fat and sodium, both of which can contribute to an increased risk of heart disease if you consume too much. They are also some of the most popular choices among EatingWell fans, so you can count on a delicious dinner. You’ll love options like our Garlicky Cabbage Soup and our Herb-Marinated Veggie & Chickpea Salad for nourishing meals that will keep your heart beating strong and healthy. Love any of these recipes? Join MyRecipes to save, search and organize your…

Nanoplastics and microplastics are small particles of plastic that can end up in your body.These microscopic particles are prevalent in disposable water bottles.Switch to reusable water bottles, like glass or stainless steel, to help limit your risk. We know we need to stay well-hydrated for our bodily systems to function properly and for overall good health. You can see evidence of people embracing this concept in the number of people who carry a water bottle everywhere they go. But does the type of bottle matter? Centuries ago, people used animal skins to carry water on the go. Eventually, metal containers…

Understanding how rheumatoid arthritis progresses from an asymptomatic stage to causing debilitating pain may help researchers improve patient outcomes.Image credit:©iStock, shurkin_sonMillions of people around the world suffer from rheumatoid arthritis, an autoimmune disorder that causes debilitating joint swelling and pain. Researchers have been looking for ways to identify those who are at risk of developing rheumatoid arthritis to help stop the disease before it causes pain and improve patient outcomes. To do this, they first need to understand how rheumatoid arthritis develops. In a recent multi-year study, researchers from multiple institutions joined forces to study the molecular profiles of patients…

Excess deaths in Scotland that were linked to delays in emergency department admission increased by a third last year, shows an analysis by the Royal College of Emergency Medicine (RCEM).The college estimates that in 2024 some 16 deaths a week were associated with long waits for emergency care.1Fiona Hunter, vice president of RCEM Scotland, said, “The fact that the deaths of more than 800 patients have been lost due to a system in crisis is a national tragedy. These are patients who are sick and need further care on a ward.“So, they are forced to endure extreme wait times for…