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As mRNA-based therapeutics move beyond early vaccine successes to encompass diverse modalities, the expectations for manufacturers to deliver products with consistent purity and quality are rising. To that end, traditional purification and quantitation processes will need to evolve to address current and new manufacturing challenges. Specifically, immunogenic double-stranded RNA (dsRNA) byproducts are a major impurity complicating the purification of RNA-based vaccines and therapeutics consisting of mRNA, circRNA, or saRNA. In addition, current UV methods of nucleic acid quantitation require extra sample handling in the form of dilutions, which can lead to inaccuracies in measuring mRNA concentration.In this GEN webinar, Rice…
Meal Plan at a Glance BREAKFAST/ A.M. SNACK LUNCH/ P.M. SNACK DINNER Yogurt, blueberries & walnuts/ Egg & bell peppers Green salad & apple/ Edamame Salmon & couscous Spinach egg scramble/ Almonds Chicken orzo soup/ Kefir & orange Beef & broccoli Toast & nut butter/ Edamame Chicken orzo soup/ Yogurt & plum Lentils & rice Yogurt, blueberries & walnuts/ Egg & raspberries Chicken orzo soup/ Almonds & blackberries Chicken Caesar pasta salad Toast & nut butter/ Yogurt & raspberries Chicken orzo soup/ Egg Pasta & Greek salad Yogurt, blueberries & walnuts/ Edamame Chickpea tuna salad/ Pear Shrimp risotto & green…
This article by Sara Raza and colleagues (BMJ 2025;391:e086300; doi:10.1136/bmj-2025-086300, 10 October 2025) mentioned unintended pregnancies associated with use of the Natural Cycles app. It has been amended to clarify that the failure rate of the app was within the expected range.
Credit: FatCamera/Getty Images Five key genes have been linked with aggressive or metastatic prostate cancer in men of African descent, according to the largest study to date in this population. Men carrying disease-causing variants in these predisposition genes were up to six times more likely to develop prostate cancer than others, with risk varying widely among the thousands of individuals studied. However, it could be more precisely gauged using information on germline pathogenic variants from predisposing genes, family history and a polygenic risk score. The research, in European Urology, suggests that stratified cancer screening programs could therefore help to identify…
The Connection Between Masturbation and UTIsThere are many known benefits of masturbating, like better sleep and lower stress, and doing it doesn’t increase your risk of getting a UTI on its own. But many of the actions that are part of sex and masturbation could contribute to UTIs by introducing bacteria that doesn’t belong into the urethra.“While masturbation itself does not increase the risk of UTIs, certain types of products associated with it, such as lubrication or toys, can,” says Dr. Grover.For example, she says that lubes can mess with the pH of the urogenital flora, the naturally occurring bacteria…
Galaxy M61 sports a long stellar stream, which had not been spotted before now.Credit: NSF–DOE Vera C. Rubin Observatory/NOIRLab/SLAC/AURA/A. Romanowsky et. al.Mere months after its long-awaited debut, the Vera C. Rubin Observatory is beginning to deliver on its promise to rewrite cosmic history. The observatory’s colossal camera — perched atop a mountain in Chile — has yet to begin its official scientific survey. But just by perusing its first test image, astronomers have uncovered a surprise: a trail of light — called a stellar stream — extending from a well-known galaxy, suggesting that the galaxy once tore apart a much…
This week’s dinner plan features recipes with at least 6 grams of fiber per serving to help you meet your nutrition goals. Eating enough fiber from foods like whole grains, vegetables and fruits helps support heart health, healthy digestion and more. From our chili-topped sweet potatoes to chicken tortilla soup, these balanced meals all come together in 30 minutes or less. Most Americans aren’t getting enough fiber, with only about 7% meeting their needs in their typical diets. But fiber is really important for a variety of body functions, including supporting heart health, aiding in healthy digestion and even lowering chronic disease…
uniQure’s “game changing” data announced in September, which showed significant slowing of Huntington’s disease (HD) progression in patients treated with its gene therapy candidate AMT-130, may not be enough to secure FDA approval. We also discuss Recursion’s pivotal leadership transitions, as Najat Khan, PhD, chief R&D officer and chief commercial officer, is set to take over as the company’s CEO effective January 1. The AI drug developer has made big bets filling the biology data gap and recently announced a “Google Map of the brain” to advance neurodegenerative disease targets. In open-source AI for drug discovery, the release of the…
Monthly GLP-1 costs will drop to $350 or less under TrumpRx starting in 2026.Medicare patients may pay as little as $50/month for Wegovy and Zepbound.GLP-1 drugs are one part of a healthy lifestyle, not a quick fix for weight loss. The Trump Administration has just announced price agreements with pharmaceutical companies Novo Nordisk and Eli Lilly that will make some GLP-1s more affordable for Americans, including people enrolled in Medicare. The increased accessibility of these drugs, like Ozempic, may see further downward shifts in adult obesity rates. Here’s what to know. According to the Gallup National Health and Well-Being Index,…
A trust has axed free tea and coffee for its staff in an attempt to save money.University Hospital Southampton NHS Foundation Trust confirmed that it has stopped providing milk, tea, and coffee for most staff in order to save £50 000 a year. This follows an announcement in May that the trust was cutting 750 jobs from its workforce of around 13 000 to save £110m from its £1.3bn turnover.The decision was made as part of wider requirements for the trust to live within its financial means, it said.The BMJ understands that the trust initially planned to pause free refreshments for all…