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A map of the immune cell landscape found in the bone marrow of patients with multiple myeloma could shed light on how the immune system interacts with cancerous plasma cells. It could also help scientists determine how aggressive a patient’s cancer is likely to be, as well as drive the development of more effective immune-based therapies.   The map is the subject of a new Nature Cancer paper titled “A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma.” The study was done by a group of scientists from multiple institutions, including Washington…

View eBook The landscape of proteomics technologies has traditionally been defined by trade offs between coverage—the ability to detect many proteins—and detail—the ability to confidently measure the abundance of every detected protein as well as the ability to quantify proteoforms. In this eBook, we explore the pros and cons of emerging and traditional proteomics technologies in terms of coverage and detail. Furthermore, we discuss how the NautilusTM Proteome Analysis Platform is designed to employ a novel proteomic analysis method called Iterative Mapping to overcome tradeoffs between coverage and detail and deliver a complete proteomics solution. Previous articleCellares and City of…

Aragen Biologics launched CHOMax™, a new cell line development and early manufacturing platform that the company says supports an integrated path from DNA to IND-enabling clinical supply for suitable standard IgG monoclonal antibodies. CHOMax has been refined across 200+ CHO programs and integrates cell line development, process development, analytics, and GMP manufacturing under quality processes designed to meet global regulatory expectations including FDA, EMA and PMDA, according to Subodh Deshmukh, CEO, Aragen Biologics, adding that CMC activities can run in parallel where appropriate. Client programs using CHOMax follow platform-defined workflows and phase-appropriate practices across the development lifecycle, notes Ashu Tandon, COO. “By combining…

Credit: wildpixel / iStock / Getty Images Plus IDH-mutant glioma is the most common malignant brain tumor in adults under 50, yet it remains one of the most difficult to treat. Even after extensive surgery and therapy, recurrence is common. A new study from the Korea Advanced Institute of Science and Technology (KAIST) and Yonsei University Severance Hospital, published in Science, suggests a fundamental reason why: the cancer may already be widespread in the brain long before it can be seen. Rather than emerging suddenly as a discrete tumor mass, the researchers show that IDH-mutant gliomas begin quietly, within normal-appearing brain tissue, and…

Credit: BlackJack3D/Getty Images In November 2024, Boltz-1 debuted as a fully commercially available AI model to achieve AlphaFold 3-level accuracy in predicting the 3D structure of biomolecular complexes. Since that time, the Massachusetts Institute of Technology (MIT) research team has continued to push a new standard in open-source AI-based drug development.   In less than 18 months, the Boltz series of models have achieved accurate binding affinity prediction (Boltz-2) and therapeutic design across a wide array of drug modalities (BoltzGen) with more than 100,000 scientists across thousands of biotechs implementing Boltz to accelerate discovery.   Led by freshly minted PhD graduates, Gabriele Corso, PhD, and Jeremy Wohlwend, PhD, and research scientist, Saro Passaro, the MIT Computer Science and Artificial Intelligence…

The Trump administration’s overhauling of the decades-old childhood vaccination schedule, announced by federal health officials on January 5, 2026, has raised alarm among public health experts and pediatricians.The US childhood immunization schedule, the grid of colored bars pediatricians share with parents, recommends a set of vaccines given from birth through adolescence to prevent a range of serious infections. The basic structure has been in place since 1995, when federal health officials and medical organizations first issued a unified national standard, though new vaccines have been added regularly as science advanced.That schedule is now being dismantled.In all, the sweeping change reduces…

Credit: GSO Images / The Image Bank / Getty Images Researchers based at University College London claim that the ε3 and ε4 variants of the APOE gene are responsible for most cases of Alzheimer’s disease. As reported in npj Dementia, an analysis using individuals with two copies of the protective ε2 variant as a comparator, 71–93% of Alzheimer’s and cerebral amyloidosis was attributable to ε3 and ε4 and around 44% of dementia. “When we consider the contributions of ε3 and ε4, we can see that APOE potentially has a role in almost all Alzheimer’s disease. Consequently, if we knew how…

Bionova Scientific, an Asahi Kasei CDMO, formed a manufacturing alliance with Syenex, a genetic medicines platform company, designed to expand global access to DNA plasmids for next-generation gene delivery for advanced cell and gene therapies. According to Darren Head, president of Bionova Scientific, at the core of Bionova’s plasmid DNA technology is its genetically stable cell line platform that has been engineered to eliminate insertion sequence elements (ISEs), cryptic prophages, and nonessential bacterial genomic regions. This IS-free host architecture significantly reduces plasmid rearrangements, deletions, and genetic instability, the “key risks that can compromise downstream lentiviral vector yield, batch-to-batch consistency, and…

On sunny days, many people often flock outside. But it’s common to notice how differently people’s skin reacts to the same amount of sunlight. Some develop a golden tan or even a dusting of new freckles after spending hours outdoors, while others turn red and experience a painful sunburn.But what causes these reactions? According to Pedram Gerami, a dermatologist and dermatopathologist at Northwestern University, these differences are multifactorial. They are influenced by genetics, skin type, and melanocytes—cells that produce melanin, the pigment that colors skin and helps protect it from ultraviolet (UV) radiation. Understanding these factors helps explain individual responses…

Looking toward London 2026, new speakers broaden the agenda across longevity finance, metabolic health and clinics. The Longevity Show has revealed a second wave of speakers for its inaugural London event next June, continuing to build a program designed to bridge geroscience, clinical practice and the increasingly longevity-literate public. If the first announcement signaled ambition, this latest slate deepens the conversation – adding experts who sit at the intersection of prevention, performance and the economic realities of longer lives. What stands out is the breadth of entry points into healthy longevity. Alongside leaders shaping population health and the emerging longevity…