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Credit: vchal/Getty Images Researchers from Integra Therapeutics, in partnership with the Pompeu Fabra University (UPF) and the Center for Genomic Regulation (CRG), Spain, have used generative AI to design synthetic proteins that outperform naturally occurring proteins used for editing the human genome. Their use of generative AI focused on PiggyBac transposases, naturally occurring enzymes that have long been used for gene delivery and genetic engineering, and uncovered more than 13,000 previously unidentified PiggyBac sequences. The research, published in Nature Biotechnology, has the potential to improve current gene editing tools for the creation of CAR T and gene therapies. “Our work…

A new study finds that a Mediterranean diet may improve psoriasis severity in patients with the skin condition. The researchers suggest that the diet could be an effective therapeutic to help control skin outcomes.The publication in JAMA Dermatology reported on a randomized clinical trial of 38 adults with mild to moderate psoriasis over 16 weeks.The researchers highlight a lack of randomized clinical trials testing diet impacts on preventing or treating psoriasis. Study results The researchers found that the participants showed a significant reduction in the Psoriasis Area and Severity Index (PASI) compared to the control group, which received advice to consume low-fat…

These cozy casseroles are packed with fiber, prebiotics and probiotics to keep your gut healthy and strong.Each recipe uses wholesome ingredients like beans, whole grains and veggies that support digestion and overall wellness.With simple prep and comforting flavors, this weekly plan makes eating for gut health easy and satisfying. The temperatures have dropped a little, which means it’s casserole season. It’s so nice to do a little prep work and pop something delicious into the oven to finish cooking while you get in a little relaxation time. As an added bonus, this week’s casseroles can also help improve your digestive…

Bacterial growth depends on available nutritional and environmental conditions, which are influenced by how many and which types of bacteria are growing in a given setting.©iStock, spawnsScientists assess bacterial growth trajectories to better predict infectious capacity and the conditions that aid proliferation. This article explores the key factors that influence bacterial replication, the distinct phases of the bacterial growth curve, methods for measuring bacterial expansion, and predictive bacterial growth models in the food industry.What Is a Bacterial Growth Curve?A bacterial growth curve is a graphical representation of a bacterial population’s fluctuation over time.1 Bacteria are prokaryotes that typically replicate via…

Cirrus Therapeutics lands seed funding to advance gene therapy designed to prevent and reverse dry AMD by rejuvenating the retina. Ophthalmology focused biotech Cirrus Therapeutics has raised $11 million in seed financing to advance a gene therapy program that targets the underlying biology of dry age-related macular degeneration (AMD), one of the leading causes of blindness in people over 50. The Cambridge, Massachusetts–based company is pursuing an approach that aims to reverse cellular aging in the retina, with the goal of preventing and even reversing vision loss in sufferers. Dry AMD, which accounts for up to 90 percent of AMD…

Credit: Chris Ratcliffe/Bloomberg via GettyResearchers are turning to artificial intelligence (AI) to help design the next generation of antibiotics to combat rising antimicrobial resistance. In minutes, AI can design thousands of chemical compounds with potential antibacterial properties, although there are hurdles to overcome before the first of these medicines can be tested in people.Last week, the US Centers for Disease Control reported that rates of dangerous bacterial infections surged by 69% between 2019 and 2023. Enterobacterales bacteria, also called ‘nightmare bacteria’, are particularly difficult to treat with existing antibiotics. Globally, 1.1 million deaths a year are linked to bacterial resistance…

You have full access to this article via your institution. Head of the US Food and Drugs Administration Marty Makary at the White House on 22 September.Credit: Andrew Harnik/GettyOn 22 September, the United States’ top public-health officials stood alongside President Donald Trump at the White House and delivered a message that went around the world in an instant. The US Food and Drug Administration (FDA) said it intends to change its guidance on acetaminophen — also known as paracetamol — a household painkiller marketed in the United States as Tylenol. The FDA published a statement saying that the agency is…

Ina Garten’s creamy mustard chicken recipe is trending on TikTok, winning over Gen Z cooks.This one-skillet meal with crispy chicken thighs and mustard sauce is simple and flavorful.Pair the dinner with an easy salad or quick roasted veggies for a weeknight bite. Ina Garten’s impact spans generations, and that was proven true with an iconic Barefoot Contessa recipe going viral last week. The cookbook author and television host has sparked the interest of Gen Z as a recent video on TikTok (from user Susie Ropp) highlighting one of her quick chicken dinners received nearly a quarter of a million views—proving…

The UK’s current method of recording covid-19 cases “is not a sensible approach to managing the spread of infection,” virologists have warned.Latest data showed an uptick in the number of UK covid cases and hospital admissions that experts said was “worrying, so early in autumn.”The latest surveillance report from the UK Health Security Agency (UKHSA) showed that in the week starting 15 September the overall weekly hospital admission rate for covid was 2.73 per 100 000 people. This was up by 60% from a month prior, when the rate was 1.71 per 100 000 in the week starting 18 August.1 And latest…

Credit: sorbetto/Getty Images French biotech EG 427 reports positive results from a trial of its gene therapy to target incontinence in people with spinal cord injury where nerve damage has caused bladder control problems. Nerve damage impacting the bladder, known as neurogenic detrusor overactivity, impacts at least two million patients with spinal cord injury, multiple sclerosis, Parkinson’s disease, and other neurological diseases around the world. While treatments are available for this condition, they are associated with potentially significant side effects and are not very effective or long lasting. EG 427’s initial Phase I/II trial results show an 88% reduction in…