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Our favorite shoe deal right now is the Adidas Astrastar Sneaker, which is up to 49% off on Amazon.  It’s also a great time to upgrade your running shoes: Consider the Hoka Mach 6 at REI.com, a podiatrist-recommended shoe, or an editor favorite, the Hoka Kawana 2 at Zappos.com.  These popular picks are likely to sell quickly, so snag them now while you can!  It’s Black Friday—the biggest shopping day of the year—and while millions of deals are flooding the internet, we narrowed in on the best discounts to help you step up your footwear game.  Whether you’re in the…

Amniotic fluid surrounds the developing fetus throughout pregnancy, providing nutrients and other support. A new model could help researchers study this material to improve neonatal care.Image credit:©iStock.com, AldonaMany factors, including genetics, stress, and environmental exposure, can shape pregnancy and fetal development. Physicians who care for pregnant patients and their babies before and after birth work to improve the outcomes for both parties throughout gestation and delivery. While scientific advancements have led to many improvements in this area, there are still aspects of pregnancy that remain a black box.“We all understand how important the placenta is in terms of that prenatal…

While Amazon’s main page is filled with great Black Friday deals right now, there’s a secret section that’s hiding some deep, deep discounts you may not find otherwise: the Amazon Outlet. This corner of the site features overstock items, many of which are from top brands and are marked down. I found 50 of the best deals for you to shop right now, including some of our favorites, and organized them for easy, fuss-free shopping below.   Amazon Best Overall Amazon Outlet Black Friday Deals We found kitchen tools, cookware, appliances and more essentials to make healthy recipes at home this…

Surgeons could use pre-tied slipknots to precisely control the tension of stitches. Credit: Addictive Stock Creatives/AlamyInserting easy-to-release slipknots into surgical thread could help surgeons to tie perfect sutures — tight enough to help heal a wound but not so tight that they damage tissue.Researchers worked out how to precisely control a knot’s geometry and friction so that they could ‘program’ it to open when tugged on with a specific force.This allows a surgeon — or a robot — stitching up a wound to pull a suture closed with just the right amount of force, tugging the free end of the…

You may not know that you have bedbugs until you see a bite on your body, as the insects themselves are notoriously hard to spot. The biting usually happens while you are sleeping, typically an hour or so before dawn, from bedbugs hiding in your bed.[2]“Bedbugs want to be as unnoticed as possible, which is why they retreat to the deepest, darkest crevices in your home, your apartment, or your hotel,” says Eric Braun, an Entomological Society of America–certified entomologist and technical services manager at the pest-control company Rentokil Terminex. “If they’re observed or spotted, they don’t have any means…

Yadav, N., Toader, A. & Rajasethupathy, P. Beyond hippocampus: thalamic and prefrontal contributions to an evolving memory. Neuron 112, 1045–1059 (2024).Article  CAS  PubMed  Google Scholar  Agranoff, B. W. & Klinger, P. D. Puromycin effect on memory fixation in the goldfish. Science 146, 952–953 (1964).Article  ADS  CAS  PubMed  Google Scholar  Flexner, L. B. & Flexner, J. B. Effect of acetoxycycloheximide and of an acetoxycycloheximide-puromycin mixture on cerebral protein synthesis and memory in mice. Proc. Natl Acad. Sci. USA 55, 369–374 (1966).Article  ADS  CAS  PubMed  PubMed Central  Google Scholar  Squire, L. R. & Barondes, S. H. Actinomycin-D: effects on memory at different…

Bold new senolytic immunotherapy targets aging at its roots – with early data suggesting wide-reaching longevity and anti-cancer potential. Miami-based longevity biotech Immorta Bio has announced the publication of its international patent application for SenoVax, a first-in-class senolytic immunotherapy designed to eliminate senescent cells, the dysfunctional “old cells” that accumulate with age and drive chronic disease [1]. The published patent outlines a novel “senescence vaccine” strategy that aims to train the immune system to identify and destroy these problem cells precisely. Unlike traditional senolytic drugs, which chemically force senescent cells to self-destruct, SenoVax works by immune activation, a potentially safer…

If you ate too much sugar last night, there are things you can do to get back on track.The first thing to do is start with a balanced breakfast that’s rich in protein and fiber. Your blood sugar will rebound more efficiently, and you’ll have better energy. After a night of eating more sugar than you’d like, you may be tempted to try to make up for it by taking drastic measures, like skipping meals. However, this plan can backfire, leading to chaotic blood sugar levels, not to mention more hunger. “After a night of too much sugar, the goal isn’t…

Vitamin B6 with a recommended daily dose of over 50mg but 200mg or less will be sold as ‘pharmacist-only’ supplements in Australia from June 2027. (Bet_Noire/Getty Images/iStockphoto)Vitamin B6 supplements with a recommended daily dose of over 50mg but 200mg or less will be sold as ‘pharmacist-only’ products in Australia from June 2027. Over 100 products will be affected by the new regulation. Australia’s Therapeutic Goods Administration (TGA) announced the above today (Nov 25), after considering feedback from the industry and the public over the risk of peripheral neuropathy associated with vitamin B6 supplementation. The lack of a synchronised halal certification…

Hibernating animals go into a state of torpor wherein they lower their metabolic rate and internal temperature.Image credit:© iStock.com, Edwin_ButterAs leaves fall off the trees and temperatures grow bitingly cold, many animals prepare to hibernate for the winter. During this period, animals enter a state of torpor wherein they reduce their metabolic activity and lower their body temperature, which helps them conserve energy. Organisms can also enter other kinds of dormancy or adaptations to stressful environments that resemble hibernation. While studying these behaviors can teach scientists more about the unique biology of these animals, it can also inform human health…