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Novo Nordisk has filed for FDA approval of a higher-dose Wegovy injection, backed by strong trial data and a national priority voucher. Pharma giant Novo Nordisk has filed for US approval of a higher-dose version of Wegovy, its blockbuster obesity drug. The company has submitted a supplemental New Drug Application (sNDA) to the US Food and Drug Administration (FDA) for a 7.2 mg, once-weekly semaglutide injection – nearly triple the current 2.4 mg dose. The application is being fast-tracked under the FDA’s new Commissioner’s National Priority Voucher (CNPV) program, allowing a decision in as little as one to two months…

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The study used the Collagen Activator supplement from Switzerland-based longevity startup Avea Life AG. The product is built around Colgevity, a patented vegan collagen precursor developed in cooperation with ETH Zurich that is a combination of glycine, proline and hydroxyproline in a 3:1:1 ratio. The consumer product is also formulated with alpha-ketoglutarate, astaxanthin, and vitamin C from acerola cherry. The new paper explored the potential of the Colgevity amino acid combination to prolong lifespan in a range of pre-clinical models, including C. elegans, lab mice and human cell lines. A subsequent human clinical trial with the full formulation with the…

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Lucille Ball’s Apple John combines spiced apples with biscuit topping for a cozy dessert.The recipe uses boxed biscuit mix, making it easy and holiday-friendly.Serve it warm with ice cream, whipped cream, or even sharp cheddar cheese. Lucille Ball was undoubtedly famous for her comedic talents, but it turns out she had a few tricks up her sleeve in the kitchen, too. And I’m not talking about her giant loaf of bread, but rather the Apple John that she often treated her real-life dinner guests to. Her quick and easy dessert was featured in the December 1964 issue of Good Housekeeping—alongside…

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Aplin, K. L. & Fischer, G. Lightning detection in planetary atmospheres. Weather 72, 46–50 (2017).Article  ADS  Google Scholar  Eden, H. F. & Vonnegut, B. Electrical breakdown caused by dust motion in low-pressure atmospheres: considerations for Mars. Science 180, 962–963 (1973).Article  ADS  CAS  PubMed  Google Scholar  Mills, A. A. Dust clouds and frictional generation of glow discharges on Mars. Nature 268, 614–614 (1977).Article  ADS  CAS  Google Scholar  Kahre, M. A. in The Atmosphere and Climate of Mars (eds Haberle, R. M. et al.) 295–337 (Cambridge Univ. Press, 2017).Stow, C. D. Dust and sand storm electrification. Weather 24, 134–140 (1969).Article  ADS  Google…

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A new peer-reviewed clinical study conducted at Maastricht University in the Netherlands supports the beauty benefits of Bonolive, Solabia Nutrition’s ingestible Manzanilla olive leaf extract for women’s health. Bonolive is standardized for 40% oleuropein and backed by previous clinical studies in menopausal women for its beneficial effects on increasing bone-formation markers, reducing joint pain, and improving blood lipid profile.In this beauty context, Solabia Nutrition’s internal R&D team collaborated with the Dutch researchers on the randomized, double-blind, placebo-controlled trial examining 12 weeks of daily supplementation with Bonolive.The research team set out to determine if the ingredient influences circulating biomarkers of tissue…

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Dietitians say that certain mealtime strategies can help you fight off that post-meal sleepy feeling. Choosing a combo of protein, fat and carbs can help along with hydrating, getting enough sleep and taking a walk after eating.Eating smaller meals rather than a large meal can help your body feel less sleepy after eating. Food is literally energy for your body, but if you’re fighting the urge to curl up for a nap after a meal, you might be wondering what gives? This all-too-common post-meal sleepiness has a scientific name, postprandial somnolence (sometimes referred to as a “food coma”). There are a…

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Aging researcher expands on how addressing 100 key problems can provide the field with a roadmap for future investigation. Earlier this week, we brought you the news of a new paper in Geroscience that maps out the most pressing unanswered questions in the science of aging. Entitled Open problems in aging science: a roadmap for biogerontology, the study distilled a final set of 100 open problems spanning molecular and cellular mechanisms, comparative biology and model organisms, biomarkers of aging, and therapeutic interventions. The result is a structured snapshot of where aging research stands today, highlighting both long-standing fundamental mysteries and…

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This hearty salad is perfect for using leftover chicken or turkey from Thanksgiving.Loaded with antioxidants, this salad provides immune-boosting nutrients.To make it vegetarian, swap the chicken with white beans and choose a feta made without animal rennet. This Kale & Sweet Potato Salad with Chicken is the ultimate cold-weather salad. Kale and sweet potatoes are rich in vitamins A and C—perfect for supporting your immune system during cold and flu season. Plus, their fiber, combined with the protein in the chicken, will help you feel full and satisfied. The sweet potatoes develop a roasty caramelization, bringing out their natural sweetness,…

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The Max Planck Institutes in Germany house cutting-edge equipment, such as this ultra-high vacuum facility at The Max Planck Institute of Microstructure Physics in Halle. Credit: Hendrik Schmidt/dpa/ALAMYIn 2019, shortly after finishing her master’s at Nanjing University in China, Xinyi Zhao opened an e-mail to learn that she had been offered a PhD position at the Max Planck Institute for Demographic Research in Rostock, Germany. “When I told my parents, they asked me to double-check whether the offer was real, as they weren’t familiar with the institute.” But Zhao knew of its glowing scientific reputation. “I felt very excited but…

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