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Cell linesB16-F0 (ATCC; CRL-6322) and its LN metastatic derivatives: NBF0-LN1-18IL, NBF0-LN7-1112AR, NBF0-LN7-1120BL, NBF0-LN7-1134BL, NBF0-LN8-1194BR, NBF0-LN8-1198AR, NBF0-LN8-1205BL, NBF0-LN9-1315BL and NBF0-LN9-1358IR—were provided by the Reticker-Flynn Laboratory. For simplicity, these cell lines are referred to throughout the manuscript as: B16-F0, LN1-18IL, LN7-1112AR, LN7-1120BL, LN7-1134BL, LN8-1194BR, LN8-1198AR, LN8-1205BL, LN9-1315BL and LN9-1358IR, respectively. B16F10 wild-type (WT), B16F10 Fsp1-KO and B16F10 Gpx4-KO cells were obtained from the Conrad Laboratory. B16-F0 Fsp1-KO, LN7-1134BL Fsp1-KO, LN9-1315BL Fsp1-KO, B16-F0 Gclc-overexpression, LN7-1134BL Gclc-overexpression, B16-F0 Gclc-KO and B16-F0 Nrf2-overexpression lines were generated in this study. Human melanoma cell lines MeWo, SK-MEL-5, A375, murine melanoma lines Yale University Melanoma Model (YUMM) 3.3…

Credit: humonia / iStock / Getty Images Plus Rough maps outlining the development of the brain in humans and other mammals have shed light on susceptibility to neurodevelopmental and psychiatric disorders and establish new strategies for treatment. The draft reference atlases, created by a global consortium of researchers, show how different brain cells are established in different species through neurodevelopment. Outlined in a collection of Nature research papers, they highlight how the expression of genes and identity of cells changes dynamically through development and the cellular processes involved in the creation of different brain cell types. The findings reveal time…

“Because Japan is an island, you can’t do something sketchy because they’ll bust you off the island,” she said. “It’s really a long game, so doing shortcuts really doesn’t work. And so that really results in things like quality, orientation, reputation, reliability, and these are things that I think being an immigrant, we’ve really protected those values.”After two decades at major pharmaceutical and biotech companies, Yamada-Lifton took the helm of her father’s 48-year-old nutritional supplements company in 2023. Her journey was shaped by both parental influences—her father’s entrepreneurial vision and her mother’s emphasis on independence.“So in Japan, they have dynasties,…

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Cocktails often contain added sugar, which can have negative health consequences. Evidence is also stacking up against alcohol having health benefits. Limit or avoid alcohol to lower your risk of heart disease, cancer and dementia. If you look forward to relaxing at the end of the day with a cocktail, you’re one of many. According to a 2025 Gallup Poll, 54% of Americans report drinking alcohol at least on occasion. This is down from the 2023 reports of 62% of U.S. adults being imbibers. Experts believe this may be due to more evidence being stacked up against the supposed health…

Prunes have been gaining traction across social and mainstream media this year as a simple way to complement a GLP-1 diet, highlights the California Prune Board. The umbrella group says this visibility is helping introduce new shoppers to the category and reinforces prunes as a “prominent fixture in the snack and baking aisles.” Prunes’ nutrient-dense profile and natural fiber pair well with consumers using weight loss drugs, highlights the board.UK government statistics recently estimated that around 64% of adults are overweight or living with obesity, which is likely to propel GLP-1 medication use, reshaping shopping habits toward healthier, nutrient-rich foods.Esther…

Whether you exercise in the morning or later in the day, research shows both times can help lower blood pressure.The best time to work out is one that fits into your schedule and that you can stick with.Start slow, pick activities that you enjoy and stay consistent to see the greatest benefits. Ever sit in traffic, running late for work and feel your blood pressure rising? Blood pressure naturally fluctuates throughout the day, and factors like stress, emotions, diet—and even exercise—can all influence it. But when it stays high over time, a condition known as hypertension, it can lead to…

New research from scientists at Max Planck Institute for Biology of Ageing, Icahn School of Medicine at Mount Sinai, and their collaborators helps elucidate the neuroprotective role of microglia, the innate immune cells of the brain, and points to a possible therapeutic pathway for Alzheimer’s disease. Details of their work are published in a new Nature paper titled “Lymphoid gene expression supports neuroprotective microglia function.”   Using mouse models and human cells and brain tissue, the scientists found that downregulating the transcription factor PU.1 promotes the expression of lymphoid immunoregulatory receptor proteins on microglia. They also found that deleting CD28 from this…

Public healthPoorer health is linked to votes for Reform UKPeople with poorer health are more likely to vote for the populist right wing political party Reform UK, showed a study published in BMJ Open Respiratory Research.1 Researchers analysed voting patterns in England during the 2024 general election and looked at 20 common health outcomes in each constituency, including asthma, cancer, chronic obstructive pulmonary disease, heart disease, dementia, type 2 diabetes, and obesity. The five areas that returned a Reform UK MP had the highest average prevalence of 15 of those 20 health conditions.Prostate cancerNICE approves combination for advanced casesThe National…

As the global population grows and food demand surges, farmers rely heavily on pesticides to boost crop yields and safeguard food quality—practices that have delivered undeniable economic benefits. But these chemicals don’t remain on the farm—they travel through soil, water, and air, reaching humans and other non-target organisms. These widespread exposures raise important questions about how pesticides affect the biological systems that keep us healthy. Increasingly, scientists are uncovering a key player in this story—the gut microbiota, the complex microbial ecosystem that helps regulate metabolism and immunity. Evidence suggests it may be a critical pathway through which pesticide exposure harms…