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Credit: luismmolina / iStock / Getty Images Plus Not all mutations in the tumor suppressor gene TP53 are created equal. That is the finding of researchers at Baylor College of Medicine who have discovered that while mutations in p53 are known to promote cancer, some, such as the p53 R273H mutation, can overstimulate DNA replication in cancer cells, creating genomic instability that activates an immune attack against tumors. Results of the research are published in Communications Biology. “We studied two common p53 mutants, R273H and R175H, in their ability to affect the growth of cancer cell lines in the lab,”…

These holiday recipes all received five star ratings up from our readers, making them the perfect choices to add to your dinner table this Thanksgiving. From the familiar and comforting taste of our Twice-Baked Sweet Potatoes with Marshmallows, to the fresh and tangy flavors of our Broccoli-Apple Crunch Salad, you can save all of these dishes to MyRecipes with just one simple click. Avoid last-minute stress and have tested and approved recipes just a few taps away—you can thank us later. Love these recipes? Join MyRecipes to save them all with one click. It’s so easy—and free! Twice-Baked Sweet Potatoes…

Eating chia seeds in the morning may help with appetite and blood sugar control.Soaking chia seeds boosts fiber benefits and improves digestion.Start with 1 tbsp a day to avoid digestive upset, and drink plenty of water. Tiny but mighty, chia seeds pack nearly 10 grams of fiber in just 2 tablespoons. That fiber supports gut health, stabilizes blood sugar, and may help lower cholesterol—but how and when you eat them matters, say dietitians. “Proper timing, preparation, and hydration optimize chia fiber’s impact on digestion and overall health,” says Raksha Shah, M.A., RDN. Especially if your fiber intake is typically low, you’ll…

Bozsoki, Z. et al. Ligand-recognizing motifs in plant LysM receptors are major determinants of specificity. Science 369, 663–670 (2020).Article  CAS  PubMed  ADS  Google Scholar  Lemmon, M. A. & Schlessinger, J. Cell signaling by receptor tyrosine kinases. Cell 141, 1117–1134 (2010).Article  CAS  PubMed  PubMed Central  Google Scholar  Shiu, S. H. & Bleecker, A. B. Receptor-like kinases from Arabidopsisform a monophyletic gene family related to animal receptor kinases. Proc. Natl Acad. Sci. USA 98, 10763–10768 (2001).Article  CAS  PubMed  PubMed Central  ADS  Google Scholar  Zipfel, C. & Oldroyd, G. E. Plant signalling in symbiosis and immunity. Nature 543, 328–336 (2017).Article  CAS  PubMed  ADS …

Anthony A Laverty, associate professor in public health1, James Nix, vehicles policy manager2, Cleo Kennington, consultant in emergency general surgery and major trauma3, Anna Goodman, assistant professor41Public Health Policy Evaluation Unit, School of Public Health, Imperial College London, London, UK2Transport and Environment, Brussels, Belgium3St George’s Hospital, London, UK4Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UKCorrespondence to A A Laverty a.laverty{at}ic.ac.ukParking policy, taxation, and regulation could help curb sales and health risksSports utility vehicles (SUVs) are passenger cars that have a chassis with extra ground clearance and are generally taller, wider, and heavier than…

“This is encouraging and suggests that even small, consistent increases in daily activity among sedentary individuals may be meaningful for brain health, although clinical trials will be needed to confirm these observational findings,” says the first study author, Wai-Ying Wendy Yau, MD, a cognitive neurologist at the Mass General Brigham neurology department in Boston.How Many Steps a Day Do You Need to Protect Your Brain?Researchers analyzed health data from about 300 adults between ages 50 and 90 whose brain scans revealed early biological markers of Alzheimer’s disease. At the beginning of the study, they wore pedometers over four to seven…

Credit: hapabapa / Editorial RF / iStock Editorial / Getty Images Plus Thymidine kinase 2 deficiency (TK2d) is an ultra-rare (1.64 cases per 1,000,000 people) often fatal, genetic mitochondrial disease characterized by progressive and severe muscle weakness. Those experiencing initial symptoms on or before the age of 12 years face a high risk of premature death (often occurring within three years after symptom onset). It is a debilitating disease with a severe impact on daily living, including one’s ability to walk, eat, and breathe independently and no previously approved treatment options beyond supportive care. This week, the U.S. Food and…

GWAS summary statisticsGWAS summary statistics for 305 continuous traits were downloaded from the Neale Lab (http://www.nealelab.is/uk-biobank/; v3). These regressions were run on inverse rank normal-transformed phenotypes in a subset of the UK Biobank consisting of approximately 360,000 individuals and included age, age2, inferred sex, age × inferred sex, age2 × inferred sex and principal components 1–20 as covariates. We used 5 × 10−8 as the threshold for genome-wide significance unless otherwise stated.LoF burden test summary statisticsSummary statistics for 292 LoF burden tests were downloaded from Backman et al.4. Two-hundred and nine traits overlapped with traits for which we had GWAS summary data (Supplementary Table 1). Burden…

Bridging nutrition, psychology, and technology, this postdoc aims to reduce the emotional burden of diabetes care.Image credit:Meryem Talbo, ©iStock, DonkeyWorxQ | Write a brief introduction to yourself including the lab you work in and your research background. I am Meryem K. Talbo, a postdoctoral fellow at Stanford University’s School of Medicine. I am also a registered dietitian and nutrition scientist passionate about improving health outcomes for people living with type 1 diabetes and reducing the burden of diabetes management by using technology.Q | How did you first get interested in science and/or your field of research? During my undergraduate studies in human nutrition…

Credit: Christoph Burgstedt/Getty Images A study published today in Nature reveals a unique weakness of metastatic melanoma cells that have spread to the lymph nodes. These cells were found to rely on the ferroptosis suppressor protein 1 (FSP1) to survive, opening the door for new therapeutic strategies against treatment-resistant and metastatic melanoma. Ferroptosis is a form of cell death caused by the accumulation of oxidized lipids on the cell membrane, eventually leading to its rupture. The study found that metastatic cells can adopt different strategies to protect themselves against ferroptosis depending on the location they are spreading to. In particular,…