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In manufacturing, intensification is an attractive idea. The ability to make more product, for less, using fewer resources, makes economic sense. In practice, however, it is a complex undertaking that involves rethinking all parts of the process. Courtney Hazelton-Harrington, a senior R&D scientist at Lonza Biologics, looked at process intensification in a new study and found that analytical technologies with the capacity to operate at high-throughput are a key component. “Bioprocess intensification means making biomanufacturing more productive, efficient, and sustainable, using continuous processes and advanced technologies to produce more product per unit space, time, and cost,” she told GEN after…

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Physicists determined the best and most consistent recipe for the cheesy and peppery Roman pasta dish cacio e pepe.Image credit:Martina GaibaOn September 18, 2025, the 35th First Annual Ig Nobel Prizes were announced, celebrating scientific achievements that “first make people laugh, and then make them think.” The ten prizes awarded this year fit the theme “Digestion” with awards honoring lizards’ pizza preferences to how biting flies avoid feeding from cows painted with black and white stripes.1,2This year’s Ig Nobel Physics Prize honored a delicious finding: the physics of the perfect cacio e pepe recipe—a deceptively difficult, traditional Roman pasta dish.3…

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The gut microbiome influences your health, including inflammation and illness.This study suggests a strong connection between gut health and healthy aging and longevity.Include plenty of fermented foods and fiber in your diet to support a healthy gut. Hippocrates, the father of modern medicine, has been credited with the saying that “all disease begins in the gut.” And even though he lived from 460 to 377 BCE, well before today’s technology or even the microscope, modern research has indicated that he may have had the right idea. The gastrointestinal tract is home to approximately 100 trillion microorganisms, including bacteria, fungi, viruses…

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Published in the journal Nutrients, the EuroMed-funded study found that pomegranate extract increased levels of insulin-like growth factor-1 (IGF-1), a hormone that supports normal cell growth and development, but naturally declines with age. Low levels of IGF-1 have been linked to increased oxidative stress and decreased muscle mass and bone mineral density, as well as an increased risk of cardiovascular disease, type 2 diabetes and metabolic syndrome.However, very high levels are also associated with negative effects on longevity, with studies showing that excessive levels can increase cancer risk. This suggests there is a ‘Goldilocks’ zone of IGF-1 levels, according to…

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Jeffrey K AronsonCentre for Evidence Based Medicine, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UKFollow Jeffrey on X: @JKAronsonMy taxonomy of the various types of sleuths includes: investigative sleuths, who investigate crimes: diagnostic sleuths, clinicians and pathologists who pursue medical diagnoses; research sleuths, clinicians and epidemiologists who search for the causes of diseases and academics in any discipline who undertake research of any kind; and integrity sleuths, who scrutinise the publications of others, looking for evidence of misconduct. In addition to these categories, I have also identified acronymic sleuths, or rather SLEUTHs. An acronym is a…

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Credit: blueskies9/Fotolia Results from a clinical trial following patients for three years have shown that a daily, low dose of aspirin can significantly reduce the risk of recurrence after surgery in colorectal tumors that carry mutations in the PI3K signaling pathway. This is the first biomarker-driven, randomized study to confirm the benefits of aspirin in colorectal cancer. “Aspirin is being tested here in a completely new context as a precision medicine treatment,” said Anna Martling, MD, PhD, professor of surgery at Karolinska Institutet and chief physician and colorectal surgeon at Karolinska University Hospital. “This is a clear example of how…

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Beneo is showcasing the applicability of its Orafti Inulin chicory root fiber solution in diverse food applications curated for regional snacking preferences at Vitafoods Asia 2025 in Bangkok, Thailand (September 17–19). Gut-healthy product demonstrations at the show feature a flavored prebiotic water, “brookies,” and “tea gummies.”Orafti Inulin is derived from chicory root via a gentle hot water extraction method and is one of the few prebiotics recognized internationally by the International Scientific Association for Probiotics and Prebiotics (ISAPP). Research supports that the chicory root fiber can promote the growth of bifidobacteria in the human gut, irrespective of food application or…

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