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Speaking with NutraIngredients on Oct. 29 at SupplySide Global in Las Vegas, Dr. Fabricant noted that, to his knowledge, no one at the Office of Dietary Supplement Programs (ODSP) at the U.S. Food and Drug Administration has been labeled essential and are therefore furloughed. This has implications for GMP inspections, although some are ongoing, said Dr. Fabricant, because the FDA has contracted with about 15 states to conduct inspections on behalf of the agency. The shutdown also appears to have affected the Agency’s own deadline of October to announce proposals to amend the Generally Recognized as Safe (GRAS) regulation.“We’ve reached…

Just 5,000–7,500 daily steps may slow Alzheimer’s-related brain changes.Physical activity was tied to slower tau buildup and cognitive decline.Walking more delayed functional decline by up to 51% over 9 years. Alzheimer’s disease (AD) is a condition that many of us worry about as we, or our loved ones, get older. It gradually affects memory, thinking, and the ability to carry out daily tasks. While there’s no cure yet, and there are many risk factors for developing this condition that are out of our control (like our genetics), research suggests that nearly half of all cases worldwide could be linked to…

A five-year review of health records links the long-term use of melatonin supplements with a higher risk of heart failure diagnosis and hospitalization, as well as death from any cause in chronic insomnia. However, experts and industry associations call for “caution and context” in interpreting the preliminary study’s findings on the popular sleep supplement. Although the observational study cannot prove a cause-and-effect relationship, the authors note that it raises safety concerns regarding the use of melatonin and may warrant further research. The complete research will be presented at the American Heart Association’s Scientific Sessions (Nov 7–10) in New Orleans, US. The…

Need inspiration for some quick and nourishing dinners? Try one of these 30-minute dinner recipes! Each of these dishes is loaded with anti-inflammatory ingredients like dark-colored produce, fatty fish and leafy greens to help you combat pesky symptoms of chronic inflammation like joint pain, muscle aches and mental fog. Plus, each serving contains at least 6 grams of fiber alongside probiotic and/or prebiotic foods to meet our gut-healthy parameters. Options like our Lemon-Turmeric Cabbage & White Bean Soup and our Broccoli-Cheddar Butter Beans will help you end your day on a satisfying note.  Love these recipes? Join MyRecipes to save them all…

Billionaire-backed research institute with aging and brain health in its sights closes doors due to ‘policy uncertainty and weak funding.’ Biomedical research institute Arena BioWorks is shutting down after less than two years in operation. The closure comes as persistent macroeconomic and policy challenges continue to weigh heavily on the biotechnology sector. Reportedly funded to the tune of $500 million by a group of high-profile investors that included the likes of Michael Dell, Jim Breyer, Michael Chambers and Elisabeth DeLuca, Arena had sought to merge early-stage scientific research and commercial company creation under one roof. Its founders envisioned a model…

A doctor sued by Texas state for providing gender affirming care to minors has handed in her licence and moved out of state.Texas’s attorney general, Ken Paxton, filed a lawsuit against May Lau in October 2024 for providing at least 21 adolescents with the hormone testosterone. But Paxton said that despite Lau’s actions he was not dropping the case against her.1“May Lau has done untold damage to children, both physically and psychologically, and the surrendering of her Texas medical licence is a major victory for our state,” he said. “My case against her for breaking the law will continue, and…

AnimalsThis study followed some applicable aspects of the PREPARE89 planning guidelines checklist, such as the formulation of the in vivo study, dialogue between scientists and the animal facility, and quality control of the in vivo components in the study. All animals were born, bred and housed at the Karolinska Institutet, Comparative Medicine Biomedicum animal facility (KMB). Mouse brain tissues (postnatal days P0, P2, P5, P7, P10 and P21) were obtained from a mouse line generated by crossing Sox10:cre animals (The Jackson Laboratory, 025807) on the C57BL/6j genetic background with RCE:loxP (eGFP) animals (The Jackson Laboratory, 32037-JAX) on a C57BL/6xCD1 mixed genetic…

Mouse breeding and husbandryAll experimental procedures related to the use of mice were approved by the Institutional Animal Care and Use Committee of the Allen Institute for Brain Science (AIBS) in accordance with NIH guidelines. Mice were housed in rooms with controlled temperature (21–22 °C) and humidity (40–51%) conditions at no more than five adult animals of the same sex per cage. Mice were provided food and water ad libitum and were maintained on a regular 14:10 h light–dark cycle. Mice were maintained on the C57BL/6J (RRID: IMSR_JAX:000664) background. We excluded any mice with anophthalmia or microphthalmia.The presence of vaginal plugs was…

Credit: Artur Plawgo/Getty Images Preclinical studies by researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, showed how a new combination therapy for hormone-resistant, estrogen receptor-positive (ER+) breast cancer can tackle tumors both in mouse models and in patient-derived explants. The team’s studies suggested that a subtype of immunosuppressive tumor-associated macrophage (TAM) help ER+ breast cancer cells resist hormone therapy. They then showed how blocking these cells using anti-DLL1 and anti-PD-L1 antibodies combined with low dose tamoxifen (TMX) resulted in tumor shrinkage, reduce the number of cancer stem cells (CSCs) and reprogramed the immunosuppressive…

Credit: Md Saiful Islam Khan/Getty Images Investigators at Mass General Brigham have developed a new tumor-fighting strategy that “hijacks” a tumor cells’ innate immune machinery to effectively work against itself. The study, published in the Proceedings of the National Academy of Sciences (PNAS), details a method that induces tumor cells to generate an immune-activating molecule called cyclic GMP-AMP (cGAMP). This reacts to the presence of double-stranded DNA (dsDNA) in the cells’ cytoplasm to activate the immune system to fight the tumor. “Tumor cells comprise a significant proportion of the tumor microenvironment but are often under-utilized for immunotherapy,” said senior author…