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Credit: TanyaJoy / iStock / Getty Images Plus Missense variants remain a challenge in genetic interpretation due to their subtle and context-dependent effects. While current prediction models perform well in known disease genes, generalizability is limited in unknown areas of the proteome. In a new study published in Nature Genetics titled, “Proteome-wide model for human disease genetics,” researchers from Harvard Medical School and the Center for Genomic Regulation (CRG) in Barcelona have popEVE, a deep generative model combining evolutionary and human population data to estimate variant deleteriousness on a proteome-wide scale. popEVE can assist rare disease diagnoses by allowing doctors to focus on the…
New data from exceptionally long-lived Rottweilers illuminates how lifetime hormonal context shapes late-life vulnerability. Frailty has become a central concept in geroscience because it captures not only the cumulative physiological wear accrued over time but also the steep rise in vulnerability that follows. Quantifying frailty through deficit accumulation offers a way to map healthspan, yet even individuals with similar frailty scores can diverge markedly in outcomes. A new study of exceptionally long-lived male Rottweilers now suggests that part of this divergence may lie in the lifelong integrity of the hypothalamic-pituitary-gonadal (HPG) axis – and that early endocrine disruption may leave…
Whether produced via hybridoma or recombinant DNA technology, monoclonal antibodies are fundamental to scientific research.©iStock, bodymIn 1985, muromonab, indicated for the treatment of transplant rejection, became the first therapeutic monoclonal antibody licensed for marketing. Much of the credit lies with César Milstein and Georges Köhler, who were the first to create an immortal hybridoma cell line that produced immunoglobulins with an identical amino acid sequence.1 Other groups soon built on their findings and began to create antibodies using recombinant DNA techniques. Since then, monoclonal antibodies have become fundamental to scientific research, and scientists in numerous fields now rely on timely…
Since the ingredient’s debut in 2024, the New York-based company has scaled to more than 10 million servings per run and now works with over half a dozen partners developing products featuring effera, Laura Katz, CEO of Helaina, told NutraIngredients during SupplySide Global 2025.These include collaborations with formulator Joey Savage and PricePlow on novel functional confectionery formats such as a GLP-1 support cake pop and a protein-based chocolate ball aimed at longevity-focused consumers.The company has also moved into targeted women’s health formulations. With Freemen Nutra, Helaina co-developed a clean-label chocolate supplement for postmenopausal consumers, designed to support cognitive clarity and…
Go meatless with one of these tasty dinner recipes. Plant-based protein sources like chickpeas, beans and edamame make these dinners filling and flavorful, so you can enjoy a little bit of everything, from a refreshing salad to a hearty stew. Recipes like our Fall Vegetable Stew or Cashew, Chickpea & Pasta Salad with Cilantro-Mint-Shallot Vinaigrette are perfect for two, but they’ll also work as a dinner for one with leftovers for lunch the next day. Love these recipes? Join MyRecipes to save them all with one click. It’s so easy—and free! Cashew, Chickpea & Pasta Salad with Cilantro-Mint-Shallot Vinaigrette Sara…
Now having the third-highest rate of adult obesity in Europe according to government data, the UK has extended its soft drinks levy to encompass more high-sugar beverages. Businesses have until January 1, 2028, to reduce the amount of sugar in their drinks and prevent being charged. Under the new regulations, charges will be applied to pre-packaged milk-based and milk-alternative drinks with high levels of added sugar, like supermarket milkshakes, flavored milks, sweetened yogurt drinks, chocolate milk drinks, and ready-to-drink coffees.“Many of these products can contain as much added sugar as fizzy drinks, where much of that sugar is added separately…
RESEARCH BRIEFINGS 26 November 2025 The DNA of ancient individuals dating to between 10,000 and 150 years ago reveals the existence of a long-standing, yet previously uncharacterized, lineage in the Southern Cone of South America — a region comprising what is now Argentina, Chile and Uruguay. People with this ancestry produced offspring with other, pre-existing groups in surrounding regions. Genomic data from present-day inhabitants attest to the genetic continuity of the lineage in central Argentina.
Credit: Yuichiro Chino/Getty Images Are cancer survivors more likely to get heart disease? Certain cancer drugs can cause cardiac side effects, but when patients get past that, what’s their heart disease risk? A new study from researchers at Yale suggests that cardiovascular disease in long-term cancer survivors is mainly due to the usual risk factors and not strongly influenced by cancer treatment. “Given the limited impact of cancer-specific factors,” the authors write, “cancer-agnostic risk prediction may be adequate to predict individual cardiovascular risk.” Cardiovascular disease, which is the leading cause of death worldwide, is also the leading cause of noncancer…
Sandra Saville, IPA’s Education & Communication Director and Dr. Koen Venema dive into the TIMOTHI Model, a cutting-edge in vitro system that simulates the gut environment to better study microbiota and biotics. Listen to the episode here The post Recreating the Gut: Inside the TIMOTHI Model appeared first on International Probiotics Association.
Amy Poehler credits Ina Garten with teaching her to roast the perfect chicken.Garten’s roast chicken recipe is simple, flavorful, and full of comforting touches.Learning to roast a chicken can build confidence and create connection in the kitchen. Roasting a whole chicken isn’t terribly difficult, but the process can feel overwhelming to novice home cooks. Thankfully, there are celebrity chefs like Ina Garten who break down kitchen tasks that seem daunting and make them easier to understand. Case in point, actor and comedian Amy Poehler, who credits Garten with teaching her how to roast a chicken. Garten appeared as a guest…